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Coenzymes and cofactors

Sapropterin

Also known as R-THBP, Dapropterin, Sapropterina

CAS 62989-33-7Formula C9H15N5O3Molar mass 241.25 g/molEC 636-312-4
GHS signal word: Warning. Pictograms: Harmful or irritant 38 suppliers listed Drug substance
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Sapropterin chemical structure, C9H15N5O3, CAS 62989-33-7
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
62989-33-7
Formula
C9H15N5O3
Molar mass
241.25 g/mol
EC number
636-312-4
HS code
293359
Category
Coenzymes and cofactors

What is Sapropterin?

Plain description, key identifiers and synonyms

Sapropterin is a tetrahydropterin that is 2-amino-5,6,7,8-tetrahydropteridin-4(3H)-one in which a hydrogen at position 6 is substituted by a 1,2-dihydroxypropyl group (6R,1'R,2'S-enantiomer). It has a role as a coenzyme, a cofactor, a diagnostic agent and a human metabolite.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(6R)-2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-3H-pteridin-4-one
CAS number
62989-33-7 CAS number cross-checkedOther or deprecated CAS: 27070-47-9
EC number
636-312-4
Molecular formula
C9H15N5O3
UNII
EGX657432I
InChIKey
FNKQXYHWGSIFBK-RPDRRWSUSA-N
InChI
InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17)/t3-,4+,6-/m0/s1
Canonical SMILES
CC(O)C(O)C1CNc2nc(N)[nH]c(=O)c2N1
Isomeric SMILES
C[C@@H]([C@@H]([C@H]1CNC2=C(N1)C(=O)NC(=N2)N)O)O

Synonyms

  • R-THBP
  • Dapropterin
  • Sapropterina
  • Sapropterinum
  • (6R)-L-erythro-tetrahydrobiopterin
  • 6R-5,6,7,8-Tetrahydrobiopterin
  • 6R-L-5,6,7,8-Tetrahydrobiopterin
  • sapropterine
  • (6R)-L-erythro-5,6,7,8-Tetrahydrobiopterin
  • (-)-(6R)-2-Amino-6-((1R,2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4(3H)-pteridinone
  • (6R)-2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydropteridin-4(3H)-one
  • (6R)-2-Amino-6-((1R,2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4(1H)-pteridinone
  • (6R)-2-Amino-6-((1R,2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydropteridin-4(1H)-one
  • (6R)-2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-1H-pteridin-4-one
  • 4(1H)-Pteridinone, (6R)-2-amino-6-((1R,2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-
  • (6R)-2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-3,4,5,6,7,8-hexahydropteridin-4-one
  • (6R)-2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydropteridin-4(1H)-one
  • (6R)-2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-3H-pteridin-4-one
  • (6R)-2-amino-6-((1R,2S)-1,2-dihydroxypropyl)-3,4,5,6,7,8-hexahydropteridin-4-one
  • (6R)-2-amino-6-((1R,2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-1H-pteridin-4-one
  • (6R)-2-amino-6-((1R,2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-3H-pteridin-4-one
  • (6R)-2-amino-6-((1R,2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydropteridin-4(3H)-one
  • Sapropterin (INN)
  • Sapropterin free base
  • tetrahydro-l-biopterin
Show all 32 synonyms
  • L-erythro-tetrahydrobiopterin
  • tetra-H-biopterin
  • tetra-hydro-biopterin
  • 5,6,7,8-tetra-H-biopterin
  • (R)-2-amino-6-((1R,2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydropteridin-4(1H)-one
  • (6R)-5,6,7,8-Tetrahydro-l-biopterin
  • Tetrahydrobiopterin

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
241.25 g/molcalc.
Exact mass
241.1175 Dacalc.
LogP (octanol/water)
-1.7calc.
Topological polar surface area
136.3 Ųcalc.
Hydrogen bond donors
6calc.
Hydrogen bond acceptors
7calc.
Rotatable bonds
2calc.
Heavy atoms
17calc.
Rings
2calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.56calc.
Formal charge
0calc.
Stereocentres
3calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1nc[nH]c2c1NCCN2

O=c1nc[nH]c2c1NCCN2

2 rings, 11 atoms, the 5,6,7,8-Tetrahydropteridin-4(1H)-one ring system.

60 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (16)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Sapropterin suppliers

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Where suppliers are based

38 suppliers in 12 countries

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Sapropterin price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • animal metabolite
  • antihypertensive agent
  • cardiovascular drug
  • coenzyme
  • cofactor
  • dermatologic drug
  • diagnostic agent
  • eukaryotic metabolite
  • hepatoprotective agent
  • human metabolite
  • mammalian metabolite
  • metabolite
  • pharmaceutical
  • protective agent
  • renoprotective agent

Pharmacology

Sapropterin is a Phenylalanine Hydroxylase Activator. The mechanism of action of sapropterin is as a Phenylalanine Hydroxylase Activator, and Breast Cancer Resistance Protein Inhibitor, and P-Glycoprotein Inhibitor.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Sapropterin is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Sapropterin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Sapropterin, based on the data on this page

What is Sapropterin?

Sapropterin is a tetrahydropterin that is 2-amino-5,6,7,8-tetrahydropteridin-4(3H)-one in which a hydrogen at position 6 is substituted by a 1,2-dihydroxypropyl group (6R,1'R,2'S-enantiomer). It has a role as a coenzyme, a cofactor, a diagnostic agent and a human metabolite.

Is Sapropterin hazardous?

Sapropterin carries the GHS signal word "Warning". Main hazards: causes skin irritation, causes serious eye irritation, may cause respiratory irritation. This summary is not an SDS, always read the supplier safety data sheet.

Guides for buyers

Practical guides that help when you source, ship or handle Sapropterin

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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