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Cardiovascular and metabolic drugs

Seladelpar

Also known as (+)-MBX-8025, 2-[4-[(2R)-2-ethoxy-3-[4-(trifluoromethyl)phenoxy]propyl]sulfanyl-2-methylphenoxy]acetic acid, ((4-(((2R)-2-Ethoxy-3-(4-(trifluoromethyl)phenoxy)propyl)thio)-2-methylphenyl)oxy)acetic acid

CAS 851528-79-5Formula C21H23F3O5SMolar mass 444.47 g/mol
2 suppliers listed Drug substance
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Seladelpar chemical structure, C21H23F3O5S, CAS 851528-79-5
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
851528-79-5
Formula
C21H23F3O5S
Molar mass
444.47 g/mol
HS code
293090
Category
Cardiovascular and metabolic drugs

What is Seladelpar?

Plain description, key identifiers and synonyms

Seladelpar is an orally bioavailable agonist of peroxisome proliferator-activated receptor (PPAR)-delta (PPARd), with bile acids reducing activity. Upon oral administration, seladelpar targets, binds to and activates PPARd in the liver. This induces the expression of fibroblast growth factor 21 (FGF21), which downregulates CYP7A1, the key enzyme for the synthesis of bile acids from cholesterol. By reducing CYP7A1 expression, bile acid synthesis is reduced. This leads to reduced inflammation and scarring associated with primary biliary cholangitis (PBC).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-[4-[(2R)-2-ethoxy-3-[4-(trifluoromethyl)phenoxy]propyl]sulfanyl-2-methylphenoxy]acetic acid
CAS number
851528-79-5
Molecular formula
C21H23F3O5S
UNII
7C00L34NB9
MDL number
MFCD28502443
InChIKey
JWHYSEDOYMYMNM-QGZVFWFLSA-N
InChI
InChI=1S/C21H23F3O5S/c1-3-27-17(11-28-16-6-4-15(5-7-16)21(22,23)24)13-30-18-8-9-19(14(2)10-18)29-12-20(25)26/h4-10,17H,3,11-13H2,1-2H3,(H,25,26)/t17-/m1/s1
Canonical SMILES
CCOC(COc1ccc(C(F)(F)F)cc1)CSc1ccc(OCC(=O)O)c(C)c1
Isomeric SMILES
CCO[C@H](COC1=CC=C(C=C1)C(F)(F)F)CSC2=CC(=C(C=C2)OCC(=O)O)C

Synonyms

  • (+)-MBX-8025
  • 2-[4-[(2R)-2-ethoxy-3-[4-(trifluoromethyl)phenoxy]propyl]sulfanyl-2-methylphenoxy]acetic acid
  • ((4-(((2R)-2-Ethoxy-3-(4-(trifluoromethyl)phenoxy)propyl)thio)-2-methylphenyl)oxy)acetic acid
  • 2-[4-[[(2R)-2-Ethoxy-3-[4-(trifluoromethyl)phenoxy]propyl]thio]-2-methylphenoxy]acetic acid
  • Acetic acid, (4-(((2R)-2-ethoxy-3-(4-(trifluoromethyl)phenoxy)propyl)thio)-2-methylphenoxy)-
  • Acetic acid, 2-(4-(((2R)-2-ethoxy-3-(4-(trifluoromethyl)phenoxy)propyl)thio)-2-methylphenoxy)-
  • seladelparum
  • 2-(4-(((2R)-2-Ethoxy-3-(4-(trifluoromethyl)phenoxy)propyl)thio)-2-methylphenoxy)acetic acid
  • 2-(4-((2R)-2-ethoxy-3-(4-(trifluoromethyl)phenoxy)propyl)sulfanyl-2-methylphenoxy)acetic acid
  • (R)-2-(4-((2-ethoxy-3-(4-(trifluoromethyl)phenoxy)propyl)thio)-2-methylphenoxy)acetic acid
  • MBX-8025 (Seladelpar)
  • Seladelpar?
  • (R)-2-[4-[[2-Ethoxy-3-[4-(trifluoromethyl)phenoxy]propyl]thio]-2-methylphenoxy]acetic Acid
  • KKB
  • 851528-79-5 (free base)
  • Seladelpar (USAN/INN)
  • compound 3r
  • MBX-8025, RWJ-800025
  • (R)-2-(4-(2-ethoxy-3-(4-(trifluoromethyl)phenoxy)propylthio)-2-methylphenoxy)acetic acid
  • (R)-2-(4-((2-Ethoxy-3-(4-(trifluoromethyl)phenoxy)propyl)-thio)-2-methylphenoxy)acetic acid
  • 2-[4-[(2R)-2-ethoxy-3-[4-(trifluoromethyl)phenoxy]propyl]sulfanyl-2-methyl-phenoxy]acetic acid

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
444.47 g/molcalc.
Exact mass
444.1218 Dacalc.
LogP (octanol/water)
5.05calc.
Topological polar surface area
64.99 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
11calc.
Heavy atoms
30calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.38calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(OCCCSc2ccccc2)cc1

c1ccc(OCCCSc2ccccc2)cc1

2 rings, 17 atoms, the Benzene, ((3-phenoxypropyl)thio)- ring system.

26 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Seladelpar suppliers

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All 2 suppliers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

2 suppliers in 1 country

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Seladelpar price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Hypolipidemic Agents

Roles

  • anticholesteremic drug
  • antilipemic drug
  • pharmaceutical

Pharmacology

Seladelpar is an orally available peroxisome proliferator-activated receptor delta (PPARδ) agonist that is used in combination with ursodeoxycholic acid to treat primary biliary cholangitis (PBC). Seladelpar therapy is associated with rare instances of worsening of liver enzymes during therapy but has not been convincingly linked to episodes of clinically apparent liver injury with jaundice.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Seladelpar is traded under.

HS 2930.90Indicative HS code

Organo-sulphur compounds, other

World exports in 2024
$5.83B
+0.1% vs 2023, imports $5.93B
2019 to 2024
Top exporters
  1. China40.7%
  2. United States10.9%
  3. Japan9.3%
Top importers
  1. United States13.3%
  2. Brazil12.6%
  3. China6.6%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Seladelpar is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Seladelpar, based on the data on this page

What is Seladelpar?

Seladelpar is an orally bioavailable agonist of peroxisome proliferator-activated receptor (PPAR)-delta (PPARd), with bile acids reducing activity. Upon oral administration, seladelpar targets, binds to and activates PPARd in the liver.

What is the CAS number of Seladelpar?

The CAS registry number of Seladelpar is 851528-79-5.

What is the molecular formula and weight of Seladelpar?

The molecular formula of Seladelpar is C21H23F3O5S and its molar mass is 444.47 g/mol.

What is Seladelpar used for?

Known uses and roles of Seladelpar include cardiovascular drugs in pharmaceuticals, anticholesteremic drug, antilipemic drug, pharmaceutical and hypolipidemic agents.

Is Seladelpar hazardous?

No GHS hazard classification for Seladelpar is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Seladelpar?

Seladelpar is usually classified under HS code 293090 (Organo-sulphur compounds, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Seladelpar?

CompoundList lists 2 suppliers of Seladelpar in China. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Seladelpar?

Suppliers quote Seladelpar on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Seladelpar

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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