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Cardiovascular and metabolic drugs

Simvastatin safety data

GHS hazards, precautions, first aid, handling and transport for Simvastatin. A classification summary, not a safety data sheet.
CAS 79902-63-9Formula C25H38O5

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

GHS classification

Pictograms, signal word and hazard classes of the GHS classification

GHS07: Harmful or irritant
Harmful or irritant
GHS09: Hazardous to the environment
Hazardous to the environment
Signal word
Warning

Hazard classes and categories

  • Skin Irrit. 2
  • Lact.
  • Aquatic Chronic 1

Hazard statements

H codes grouped by type. Percentages show the share of classification notifications that report the statement

Health hazards

  • H315Causes skin irritation.
  • H362May cause harm to breast-fed children.

Environmental hazards

  • H410Very toxic to aquatic life with long lasting effects.

Precautionary statements

P codes for prevention, response, storage and disposal

Prevention

  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P263Avoid contact during pregnancy and while nursing.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.

Response

  • P302 + P352If on skin: Wash with plenty of water.
  • P318If exposed or concerned, get medical advice.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P391Collect spillage.

Disposal

  • P501Dispose of contents and container in accordance with local regulations.

Handling, storage and disposal

Summaries only, follow the supplier SDS for your grade

Safe handling

Eye/face protection: Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection: Handle with gloves.

Storage

Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8 °C. Simvastatin tablets should be stored at 5-30 °C. When stored under these conditions, the tablets are stable for 24 months after the date of manufacture. The fixed-combination preparation containing simvastatin and ezetimibe should be stored in well-closed containers at 20-25 °C.

Disposal

SRP: Expired or waste pharmaceuticals shall carefully take into consideration applicable DEA, EPA, and FDA regulations. It is not appropriate to dispose by flushing the pharmaceutical down the toilet or discarding to trash. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator. Product: Offer surplus and non-recyclable solutions to a licensed disposal company, Contaminated packaging: Dispose of as unused product.

Exposure limits and toxicity

Occupational exposure limits and toxicity data

Simvastatin occasionally causes myopathy manifested as muscle pain, tenderness or weakness with creatine kinase above ten times the upper limit of normal. Myopathy sometimes takes the form of rhabdomyolysis with or without acute renal failure secondary to myoglobinuria, and rare fatalities have occurred. The risk of myopathy is increased by high levels of statin activity in plasma. Predisposing factors for myopathy include advanced age (>/=65 years), female gender, uncontrolled hypothyroidism, and renal impairment.

Supplier safety data sheets

SDS documents uploaded by suppliers who list this chemical

No supplier has uploaded an SDS for Simvastatin yet. Suppliers usually send one with their quote. Request quotes

Safety questions

Quick answers about handling Simvastatin safely

Is Simvastatin hazardous?

Simvastatin carries the GHS signal word "Warning". Main hazards: causes skin irritation, may cause harm to breast-fed children, very toxic to aquatic life with long lasting effects. This summary is not an SDS, always read the supplier safety data sheet.

Which GHS pictograms apply to Simvastatin?

The GHS classification of Simvastatin shows 2 pictograms: GHS07 (harmful or irritant), GHS09 (hazardous to the environment).

How should Simvastatin be stored?

Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8 °C. Simvastatin tablets should be stored at 5-30 °C. When stored under these conditions, the tablets are stable for 24 months after the date of manufacture. The fixed-combination preparation containing simvastatin and ezetimibe should be stored in well-closed containers at 20-25 °C.

Where can I get the SDS for Simvastatin?

Ask the supplier for the safety data sheet of the exact grade you buy. Suppliers on CompoundList can attach their SDS to listings and send it with a quote. This page is a GHS classification summary, not an SDS.

GHS classification summary, not an SDS. Always check the supplier's SDS. Last updated 7 Oct 2026. Report an error

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