Spermine (CAS 71-44-3): properties, price, suppliers and safety

What is Spermine?

Plain description, key identifiers and synonyms

Spermine is a polyazaalkane that is tetradecane in which the carbons at positions 1, 5, 10 and 14 are replaced by nitrogens. Spermine has broad actions on cellular metabolism. It has a role as an antioxidant, an immunosuppressive agent and a fundamental metabolite. It is a tetramine and a polyazaalkane. It is a conjugate base of a spermine(4+).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name: N,N'-bis(3-aminopropyl)butane-1,4-diamine
CAS number: 71-44-3 CAS number cross-checkedOther or deprecated CAS: 71052-31-8
EC number: 200-754-2
Molecular formula: C₁₀H₂₆N₄
UNII: 2FZ7Y3VOQX
MDL number: MFCD00008215
INCI name: GEROTINE, TERPENE HYDROCARBONS
InChIKey: PFNFFQXMRSDOHW-UHFFFAOYSA-N
InChI: InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2
SMILES (canonical and isomeric): C(CCNCCCN)CNCCCN

Synonyms

musculamine
neuridine
gerontine
Spermin
N,N'-Bis(3-aminopropyl)-1,4-butanediamine
Diaminopropyltetramethylenediamine
4,9-Diaza-1,12-dodecanediamine
N,N'-Bis(3-aminopropyl)butane-1,4-diamine
Spermine, puriss
1,4-Bis(aminopropyl)butanediamine
1,4-Butanediamine, N,N'-bis(3-aminopropyl)-
4,9-Diazadodecamethylenediamine
Gerotine
Spermina
4,9-Diazadodecane-1,12-diamine
Actilip sp-91
1,5,10,14-Tetraazatetradecane
1,4-Bis(aminopropyl) butanediamine
1,4-Diaminobutane, N,N'-bis(3-aminopropyl)-
(3-aminopropyl)({4-[(3-aminopropyl)amino]butyl})amine
diaminopropyl-tetramethylenediamine
1,4-Butanediamine, N1,N4-bis(3-aminopropyl)-
(3-aminopropyl)((4-((3-aminopropyl)amino)butyl))amine
N1,N1'-(Butane-1,4-diyl)bis(propane-1,3-diamine)
N,N'-Bis(3-aminopropyl)-1,4-diaminobutane

Show all 36 synonyms

N1,N4-bis(3-aminopropyl)-1,4-butanediamine
spermidine 3HCl
N,N'-bis(aminopropyl)-1,4-butanediamine
N,Na?Bis(3-aminopropyl)-1,4-diaminobutane
N,N''-bis(3-aminopropyl)butane-1,4-diamine
Spermine free base
N,N inverted exclamation marka-Bis(3-aminopropyl)-1,4-diaminobutane, Gerontine, Musculamine, Neuridine
Spermine puriss
Spermine, HCl salt
Spermine (Standard)
71-44-3 (FREE BASE)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight	202.35 g/molcalc.
Exact mass	202.2157 Dacalc.
LogP (octanol/water)	-0.36calc.
Topological polar surface area	76.1 Å²calc.
Hydrogen bond donors	4calc.
Hydrogen bond acceptors	4calc.
Rotatable bonds	11calc.
Heavy atoms	14calc.
Rings	0calc.
Aromatic rings	0calc.
Fraction sp3 carbons	1calc.
Formal charge	0calc.
Stereocentres	0calc.
Lipinski rule of five	Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word

Danger

Corrosive

Hazard statements

H314Causes severe skin burns and eye damage.
H318Causes serious eye damage.

Precautionary statements (14)

P260Do not breathe dust, fume, gas, mist, vapours or spray.
P264Wash skin thoroughly after handling.
P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
P280Wear protective gloves, protective clothing, eye protection and face protection.
P301 + P330 + P331If swallowed: Rinse mouth. Do not induce vomiting.
P302 + P361 + P354If on skin: Take off immediately all contaminated clothing. Immediately rinse with water for several minutes.
P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
P305 + P354 + P338If in eyes: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P316Get emergency medical help immediately.
P317Get medical help.
P321Specific treatment (see supplemental first aid instructions on the label).
P363Wash contaminated clothing before reuse.
P405Store locked up.
P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Spermine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 85 suppliers

Verified only30 of 30 offers

Suzhou Myland Pharm & Nutrition Inc.
China, SuzhouUnclaimed profile
SpermineGrade, purity and minimum order on request
Price on request
View
Suzhou uugene Biopharma Co., Ltd.
China, SuzhouUnclaimed profile
SpermineGrade, purity and minimum order on request
Price on request
View
001Chemical
China, HangzhouUnclaimed profile
SpermineGrade, purity and minimum order on request
Price on request
View
10X Chem
United States, San DiegoUnclaimed profile
SpermineGrade, purity and minimum order on request
Price on request
View
3WAY Pharm Inc
China, ShanghaiUnclaimed profile
SpermineGrade, purity and minimum order on request
Price on request
View
A2B Chem LLC
United States, San DiegoUnclaimed profile
SpermineGrade, purity and minimum order on request
Price on request
View
Aa Blocks LLC
United States, San DiegoUnclaimed profile
SpermineGrade, purity and minimum order on request
Price on request
View
Aaron Chemicals LLC.
China, NanjingUnclaimed profile
SpermineGrade, purity and minimum order on request
Price on request
View
AbaChemScene, LLC
United States, Monmouth JunctionUnclaimed profile
SpermineGrade, purity and minimum order on request
Price on request
View
ABCR GmbH & CO. KG
GermanyUnclaimed profile
SpermineGrade, purity and minimum order on request
Price on request
View

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

85 suppliers in 11 countries

Send one request to many suppliers

Choose up to 10 suppliers or let us match your request. Compare quotes side by side, free.

Choose suppliers Post a request

Spermine price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

Get latest price

Uses and applications

What the substance is used for, by industry and function

Industries and functions

Cosmetic ingredient, INCI name TERPENE HYDROCARBONS(perfuming)

Roles

antioxidant
fundamental metabolite
immunomodulator
immunosuppressive agent
metabolite
pharmaceutical

Functional uses

Adhesion/cohesion promoter
Fragrance
Plasticizer
Softener and conditioner
Solubility enhancer
Solvent

Cosmetic functions

Perfuming
Skin conditioning

Pharmacology

Spermine is a polyamine that has a similar structure to tetradecane but the carbons at positions 1, 5, 10 and 14 are replaced by nitrogens. Spermine plays a broad role in cellular metabolic processes.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

EU cosmetic ingredient inventory
EU Cosmetics Regulation Annex III, restricted in cosmetics
Name: Terpene hydrocarbons, Ref no: 128, Annex ref: III/128

United States

TSCA inventory (USA)
Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Spermine is traded under.

HS 2921.29Indicative HS code

Acyclic polyamines and their derivatives, salts thereof, other

World exports in 2024

$1.16B

+1.0% vs 2023, imports $1.12B

2019 to 2024

Top exporters

Japan16.6%
China14.4%
Netherlands13.6%

Top importers

Reported customs values in USD, not prices.Full trade data

The HS code shown for Spermine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Parent and salt forms, stereoisomers, similar structures and isomers

Salt and hydrate forms

Records that share this compound as their parent

Spermine hydrochloride chemical structure, C10H30Cl4N4, CAS 306-67-2

Spermine hydrochloride306-67-2C₁₀H₃₀Cl₄N₄8 suppliers

N~1~,N~4~-Bis(3-aminopropyl)butane-1,4-diamine--hydrogen chloride (1/1) chemical structure, C10H27ClN4, CAS 29605-46-7

N~1~,N~4~-Bis(3-aminopropyl)butane-1,4-diamine--hydrogen chloride (1/1)29605-46-7C₁₀H₂₇ClN₄

1,4-Butanediamine, N1,N4-bis(3-aminopropyl)-, phosphate (1:2) chemical structure, C10H32N4O8P2, CAS 3891-79-0

1,4-Butanediamine, N1,N4-bis(3-aminopropyl)-, phosphate (1:2)3891-79-0C₁₀H₃₂N₄O₈P₂

N~1~,N~4~-Bis(3-aminopropyl)butane-1,4-diamine--water (1/2) chemical structure, C10H30N4O2, CAS 403982-64-9

N~1~,N~4~-Bis(3-aminopropyl)butane-1,4-diamine--water (1/2)403982-64-9C₁₀H₃₀N₄O₂2 suppliers

N,N'-Bis(3-ammoniopropyl)butane-1,4-diaminium chemical structure, C10H30N4+4, CAS 74676-65-6

N,N'-Bis(3-ammoniopropyl)butane-1,4-diaminium74676-65-6C₁₀H₃₀N₄+₄

N,N'-Bis(3-aminopropyl)butan-1,4-diamine phosphate chemical structure, C10H29N4O4P, CAS 2779-91-1

N,N'-Bis(3-aminopropyl)butan-1,4-diamine phosphate2779-91-1C₁₀H₂₉N₄O₄P

Acetic acid--N~1~,N~4~-bis(3-aminopropyl)butane-1,4-diamine (1/1) chemical structure, C12H30N4O2, CAS 65929-23-9

Acetic acid--N~1~,N~4~-bis(3-aminopropyl)butane-1,4-diamine (1/1)65929-23-9C₁₂H₃₀N₄O₂

Platinum, (mu-(N,N'-bis(3-(amino-kappaN)propyl)-1,4-butanediamine-kappaN:kappaN'))tetrachlorodi- chemical structure, C10H26Cl4N4Pt2, CAS 187224-61-9

Platinum, (mu-(N,N'-bis(3-(amino-kappaN)propyl)-1,4-butanediamine-kappaN:kappaN'))tetrachlorodi-187224-61-9C₁₀H₂₆Cl₄N₄Pt₂

Platinum(2+) chloride--N~1~,N~4~-bis(3-aminopropyl)butane-1,4-diamine--hydrogen chloride (2/4/1/4) chemical structure, C10H30Cl8N4Pt2, CAS 187224-60-8

Platinum(2+) chloride--N~1~,N~4~-bis(3-aminopropyl)butane-1,4-diamine--hydrogen chloride (2/4/1/4)187224-60-8C₁₀H₃₀Cl₈N₄Pt₂

Platinum, (mu-(N,N'-bis(3-(amino-kappaN)propyl)-1,4-butanediamine-kappaN:kappaN'))octachlorodi- chemical structure, C10H26Cl8N4Pt2-4, CAS 187224-63-1

Platinum, (mu-(N,N'-bis(3-(amino-kappaN)propyl)-1,4-butanediamine-kappaN:kappaN'))octachlorodi-187224-63-1C₁₀H₂₆Cl₈N₄Pt₂-₄

N,N'-Bis(3-aminopropyl)butane-1,4-diamine, hydron, bis(platinum(2+)), octachloride chemical structure, C10H30Cl8N4Pt2

N,N'-Bis(3-aminopropyl)butane-1,4-diamine, hydron, bis(platinum(2+)), octachlorideC₁₀H₃₀Cl₈N₄Pt₂

Stereoisomers and isotopic forms

Same connectivity, different stereochemistry or isotopes (same InChIKey skeleton)

N,N'-Bis(3-ammoniopropyl)butane-1,4-diaminium74676-65-6C₁₀H₃₀N₄+₄

Similar structures

Nearest neighbours by Morgan fingerprint Tanimoto similarity

Spermidine chemical structure, C7H19N3, CAS 124-20-9

93% similar

Spermidine124-20-9C₇H₁₉N₃105 suppliers

Bis(3-aminopropyl)amine chemical structure, C6H17N3, CAS 56-18-8

Spermidine trihydrochloride chemical structure, C7H22Cl3N3, CAS 334-50-9

Thermospermine chemical structure, C10H26N4, CAS 70862-11-2

N~1~-(3-Aminopropyl)(~13~C_4_)butane-1,4-diamine--hydrogen chloride (1/3) chemical structure, C7H22Cl3N3, CAS 1313734-84-7

N,N'-Bis(3-aminopropyl)ethylenediamine chemical structure, C8H22N4, CAS 10563-26-5

N-(2-Aminoethyl)-1,3-propanediamine chemical structure, C5H15N3, CAS 13531-52-7

Norspermine chemical structure, C9H24N4, CAS 4605-14-5

86% similar

Norspermine4605-14-5C₉H₂₄N₄4 suppliers

Same formula isomers

Different compounds that share this molecular formula

All isomers

Thermospermine70862-11-2C₁₀H₂₆N₄1 supplier

1,4,7,10-Tetramethyltriethylenetetramine chemical structure, C10H26N4, CAS 105-78-2

1,4,7,10-Tetramethyltriethylenetetramine105-78-2C₁₀H₂₆N₄

1,3-Propanediamine, N1,N1'-1,2-ethanediylbis[N1-methyl- chemical structure, C10H26N4, CAS 999-22-4

1,3-Propanediamine, N1,N1'-1,2-ethanediylbis[N1-methyl-999-22-4C₁₀H₂₆N₄

N-(3-Aminopropyl)-N-[2-(dimethylamino)ethyl]propane-1,3-diamine chemical structure, C10H26N4, CAS 62787-29-5

N-(3-Aminopropyl)-N-[2-(dimethylamino)ethyl]propane-1,3-diamine62787-29-5C₁₀H₂₆N₄

N-Methyl-N'-(2-(3-methylaminopropylamino)ethyl)propane-1,3-diamine chemical structure, C10H26N4, CAS 77500-19-7

N-Methyl-N'-(2-(3-methylaminopropylamino)ethyl)propane-1,3-diamine77500-19-7C₁₀H₂₆N₄

Decane-1,4,7,10-tetramine chemical structure, C10H26N4, CAS 877459-76-2

Decane-1,4,7,10-tetramine877459-76-2C₁₀H₂₆N₄

1,2-Propanediamine, N1,N1'-1,2-ethanediylbis(2-methyl- chemical structure, C10H26N4, CAS 22201-11-2

1,2-Propanediamine, N1,N1'-1,2-ethanediylbis(2-methyl-22201-11-2C₁₀H₂₆N₄

1,2-Ethanediamine, N,N'-bis(2-aminoethyl)-N,N'-diethyl- chemical structure, C10H26N4, CAS 151478-83-0

1,2-Ethanediamine, N,N'-bis(2-aminoethyl)-N,N'-diethyl-151478-83-0C₁₀H₂₆N₄

N1,N2-Bis[2-(dimethylamino)ethyl]-1,2-ethanediamine chemical structure, C10H26N4, CAS 72949-93-0

N1,N2-Bis[2-(dimethylamino)ethyl]-1,2-ethanediamine72949-93-0C₁₀H₂₆N₄

N~1~,N~1'~-(Ethane-1,2-diyl)di(butane-1,4-diamine) chemical structure, C10H26N4, CAS 70862-14-5

N~1~,N~1'~-(Ethane-1,2-diyl)di(butane-1,4-diamine)70862-14-5C₁₀H₂₆N₄

Frequently asked questions

Quick answers about Spermine, based on the data on this page

What is Spermine?

Spermine is a polyazaalkane that is tetradecane in which the carbons at positions 1, 5, 10 and 14 are replaced by nitrogens. Spermine has broad actions on cellular metabolism. It has a role as an antioxidant, an immunosuppressive agent and a fundamental metabolite. It is a tetramine and a polyazaalkane.

What is the CAS number of Spermine?

The CAS registry number of Spermine is 71-44-3. Other or deprecated CAS numbers: 71052-31-8.

What is the molecular formula and weight of Spermine?

The molecular formula of Spermine is C10H26N4 and its molar mass is 202.35 g/mol.

What is Spermine used for?

Known uses and roles of Spermine include skin conditioning agents in cosmetics and personal care, fragrance ingredients in cosmetics and personal care, fragrance ingredients in flavors and fragrances, antioxidant, fundamental metabolite and 12 more.

Is Spermine hazardous?

Spermine carries the GHS signal word "Danger". Main hazards: causes severe skin burns and eye damage, causes serious eye damage. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Spermine?

Spermine is usually classified under HS code 292129 (Acyclic polyamines and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Spermine?

CompoundList lists 85 suppliers of Spermine in United States, China, United Kingdom, Germany and 7 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Spermine?

Suppliers quote Spermine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Spermine

Spermine

Key facts

What is Spermine?

Identifiers

Synonyms

Physical and chemical properties

Physical and chemical properties

Computed descriptors

Safety and hazards

Hazard statements

Spermine suppliers

Where suppliers are based

Send one request to many suppliers

Spermine price

Uses and applications

Industries and functions

Roles

Functional uses

Cosmetic functions

Pharmacology

Regulatory status

Health and food

United States

HS code and trade data

Global trade

Frequently asked questions

What is Spermine?

What is the CAS number of Spermine?

What is the molecular formula and weight of Spermine?

What is Spermine used for?

Is Spermine hazardous?

What is the HS code of Spermine?

Where can I buy Spermine?

What is the price of Spermine?

Guides for buyers

Get quotes for Spermine

Key facts

What is Spermine?

Identifiers

Synonyms

Physical and chemical properties

Physical and chemical properties

Computed descriptors

Safety and hazards

Hazard statements

Spermine suppliers

Where suppliers are based

Send one request to many suppliers

Spermine price

Uses and applications

Industries and functions

Roles

Functional uses

Cosmetic functions

Pharmacology

Regulatory status

Health and food

United States

HS code and trade data

Global trade

Related chemicals

Salt and hydrate forms

Stereoisomers and isotopic forms

Similar structures

Same formula isomers

Frequently asked questions

What is Spermine?

What is the CAS number of Spermine?

What is the molecular formula and weight of Spermine?

What is Spermine used for?

Is Spermine hazardous?

What is the HS code of Spermine?

Where can I buy Spermine?

What is the price of Spermine?

Guides for buyers

Get quotes for Spermine