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Cosmetic antioxidants

Spermidine

Also known as 1,5,10-Triazadecane, 4-Azaoctamethylenediamine, 4-Azaoctane-1,8-diamine

CAS 124-20-9Formula C7H19N3Molar mass 145.25 g/molEC 204-689-0
GHS signal word: Danger. Pictograms: Corrosive 105 suppliers listed
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Spermidine chemical structure, C7H19N3, CAS 124-20-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
124-20-9
Formula
C7H19N3
Molar mass
145.25 g/mol
EC number
204-689-0
HS code
292129
Category
Cosmetic antioxidants

What is Spermidine?

Plain description, key identifiers and synonyms

Spermidine is a triamine that is the 1,5,10-triaza derivative of decane. It has a role as an autophagy inducer, a geroprotector and a fundamental metabolite. It is a triamine and a polyazaalkane. It is a conjugate base of a spermidine(3+).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N'-(3-aminopropyl)butane-1,4-diamine
CAS number
124-20-9 CAS number cross-checkedOther or deprecated CAS: 1122077-27-3, 133483-05-3, 133483-10-0
EC number
204-689-0
Molecular formula
C7H19N3
UNII
U87FK77H25
MDL number
MFCD00008229
INCI name
SPERMIDINE
InChIKey
ATHGHQPFGPMSJY-UHFFFAOYSA-N
InChI
InChI=1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2
SMILES (canonical and isomeric)
C(CCNCCCN)CN

Synonyms

  • 1,5,10-Triazadecane
  • 4-Azaoctamethylenediamine
  • 4-Azaoctane-1,8-diamine
  • Spermidin
  • N-(3-aminopropyl)butane-1,4-diamine
  • 1,8-Diamino-4-azaoctane
  • N-(3-Aminopropyl)-1,4-butanediamine
  • N'-(3-aminopropyl)butane-1,4-diamine
  • 1,4-Butanediamine, N-(3-aminopropyl)-
  • 1,4-Butanediamine, N1-(3-aminopropyl)-
  • (4-aminobutyl)(3-aminopropyl)amine
  • N-(3-Aminopropyl)-1,4-butane-diamine
  • 1,4-Diaminobutane, N-(3-aminopropyl)-
  • N-(4-Aminobutyl)-1,3-diaminopropane
  • N-[3-Aminopropyl]-1,4-butanediamine
  • N1-(3-Aminopropyl)butane-1,4-diamine
  • N-(3-Aminopropyl)-1,4-diaminobutane
  • N1-(3-Aminopropyl)-1,4-butanediamine
  • N-(3-Aminopropyl)-4-aminobutylamine
  • SPD
  • N-(3-Aminopropyl)-1,4-diamino-butane
  • Vmp7 antigen
  • Spermidine phosphate (salt) hexahydrate
  • gp130 Signal transducer
  • N~1~-(3-azaniumylpropyl)butane-1,4-diaminium
Show all 34 synonyms
  • 1pot
  • Aminopropylbutandiamine
  • Spermidine (Standard)
  • Tocris-0959
  • Biomol-NT_000212
  • 4-04-00-01300 (Beilstein Handbook Reference)
  • DivK1c_001007
  • Spermidine, >=99% (GC)
  • Spermidine, analytical standard

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
145.25 g/molcalc.
Exact mass
145.1579 Dacalc.
LogP (octanol/water)
-0.34calc.
Topological polar surface area
64.07 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
7calc.
Heavy atoms
10calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
1calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS05: Corrosive
Corrosive

Hazard statements

  • H314Causes severe skin burns and eye damage.
  • H318Causes serious eye damage.
Precautionary statements (14)
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P330 + P331If swallowed: Rinse mouth. Do not induce vomiting.
  • P302 + P361 + P354If on skin: Take off immediately all contaminated clothing. Immediately rinse with water for several minutes.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P354 + P338If in eyes: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P316Get emergency medical help immediately.
  • P317Get medical help.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P363Wash contaminated clothing before reuse.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Spermidine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 105 suppliers
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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

105 suppliers in 17 countries

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Spermidine price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Cosmetic ingredient, INCI name SPERMIDINE(antioxidant, hair conditioning)

Roles

  • antihypertensive agent
  • autophagy inducer
  • cardiovascular drug
  • fundamental metabolite
  • geroprotector
  • metabolite
  • pharmaceutical
  • protective agent

Functional uses

  • Antioxidant
  • Fragrance
  • Softener and conditioner

Cosmetic functions

  • Antioxidant
  • Hair conditioning

Pharmacology

Spermidine is a polyamine derived from putrescine that is involved in many biological processes, including the regulation of membrane potential, the inhibition of nitric oxide synthase (NOS) and the induction of autophagy.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Spermidine is traded under.

HS 2921.29Indicative HS code

Acyclic polyamines and their derivatives, salts thereof, other

World exports in 2024
$1.16B
+1.0% vs 2023, imports $1.12B
2019 to 2024
Top exporters
  1. Japan16.6%
  2. China14.4%
  3. Netherlands13.6%
Top importers
  1. China15.2%
  2. United States11.2%
  3. Germany8.0%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Spermidine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Spermidine, based on the data on this page

What is Spermidine?

Spermidine is a triamine that is the 1,5,10-triaza derivative of decane. It has a role as an autophagy inducer, a geroprotector and a fundamental metabolite. It is a triamine and a polyazaalkane. It is a conjugate base of a spermidine(3+).

What is the CAS number of Spermidine?

The CAS registry number of Spermidine is 124-20-9. Other or deprecated CAS numbers: 1122077-27-3, 133483-05-3, 133483-10-0.

What is the molecular formula and weight of Spermidine?

The molecular formula of Spermidine is C7H19N3 and its molar mass is 145.25 g/mol.

What is Spermidine used for?

Known uses and roles of Spermidine include antioxidants in cosmetics and personal care, hair conditioning agents in cosmetics and personal care, antihypertensive agent, autophagy inducer, cardiovascular drug and 9 more.

Is Spermidine hazardous?

Spermidine carries the GHS signal word "Danger". Main hazards: causes severe skin burns and eye damage, causes serious eye damage. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Spermidine?

Spermidine is usually classified under HS code 292129 (Acyclic polyamines and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Spermidine?

CompoundList lists 105 suppliers of Spermidine in China, United States, Germany, United Kingdom and 13 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Spermidine?

Suppliers quote Spermidine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Spermidine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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