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Sweeteners

Sucralose

Also known as Splenda, Trichlorosucrose, Aspasvit

CAS 56038-13-2Formula C12H19Cl3O8Molar mass 397.64 g/molEC 259-952-2
269 suppliers listed Drug substance
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Sucralose chemical structure, C12H19Cl3O8, CAS 56038-13-2
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
White to off white, crystalline powder
Melting point
130 °C
Solubility
Freely soluble in water, methanol and ethanol, Slightly soluble in ethyl acetate
HS code
293214
Category
Sweeteners
Illustrative photo, off-white powder in an open kraft paper sack in a chemical plant
Typical packagingIllustrative packaging image, not the actual product

What is Sucralose?

Plain description, key identifiers and synonyms

Sucralose is a disaccharide derivative consisting of 4-chloro-4-deoxy-alpha-D-galactopyranose and 1,6-dichloro-1,6-dideoxy-beta-D-fructofuranose units linked by a glycosidic bond. It has a role as a xenobiotic, a sweetening agent and an environmental contaminant. It is an organochlorine compound and a disaccharide derivative.

Sucralose is a chemical compound used as an artificial sweetener.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2R,3R,4R,5R,6R)-2-[(2R,3S,4S,5S)-2,5-bis(chloromethyl)-3,4-dihydroxyoxolan-2-yl]oxy-5-chloro-6-(hydroxymethyl)oxane-3,4-diol
CAS number
56038-13-2 CAS number cross-checked
EC number
259-952-2
Molecular formula
C12H19Cl3O8
UNII
96K6UQ3ZD4
MDL number
MFCD03648615
INCI name
SUCRALOSE
InChIKey
BAQAVOSOZGMPRM-QBMZZYIRSA-N
InChI
InChI=1S/C12H19Cl3O8/c13-1-4-7(17)10(20)12(3-14,22-4)23-11-9(19)8(18)6(15)5(2-16)21-11/h4-11,16-20H,1-3H2/t4-,5-,6+,7-,8+,9-,10+,11-,12+/m1/s1
Canonical SMILES
OCC1OC(OC2(CCl)OC(CCl)C(O)C2O)C(O)C(O)C1Cl
Isomeric SMILES
C([C@@H]1[C@@H]([C@@H]([C@H]([C@H](O1)O[C@]2([C@H]([C@@H]([C@H](O2)CCl)O)O)CCl)O)O)Cl)O

Synonyms

  • Splenda
  • Trichlorosucrose
  • Aspasvit
  • Sucrazit
  • Trichlorogalactosucrose
  • Trichlorogalacto-sucrose
  • Sansweet su 100
  • 1,6-Dichloro-1,6-dideoxy-beta-D-fructofuranosyl 4-chloro-4-deoxy-alpha-D-galactopyranoside
  • San sweet sa 8020
  • 4,1',6'-trichlorogalactosucrose
  • INS NO.955
  • 1',4',6'-Trichloro-galactosucrose
  • 1,6-Dichloro-1,6-dideoxy-beta-D-fructofuranosyl-4-chloro-4-deoxy-alpha-D-galactopyranoside
  • alpha-D-Galactopyranoside, 1,6-dichloro-1,6-dideoxy-beta-D-fructofuranosyl 4-chloro-4-deoxy-
  • (2R,3R,4R,5R,6R)-2-[(2R,3S,4S,5S)-2,5-bis(chloromethyl)-3,4-dihydroxy-tetrahydrofuran-2-yl]oxy-5-chloro-6-(hydroxymethyl)tetrahydropyran-3,4-diol
  • (2R,3R,4R,5R,6R)-2-((2R,3S,4S,5S)-2,5-bis(chloromethyl)-3,4-dihydroxy-tetrahydrofuran-2-yl)oxy-5-chloro-6-(hydroxymethyl)tetrahydropyran-3,4-diol
  • 1',4',6'-trichloro-1',4,6'-trideoxygalactosucrose
  • 1',4,6'-Trichlorogalactosucrose
  • C12H19Cl3O8
  • 4,1',6'-Trichloro-4,1',6'-trideoxy-galacto-sucrose
  • Acucar Light
  • 1-(1,6-Dichloro-1,6-dideoxy-beta-D-fructofuranosyl)-4-chloro-4-deoxy-alpha-D-galactopyranoside
  • a-D-Galactopyranoside, 1,6-dichloro-1,6-dideoxy-b-D-fructofuranosyl4-chloro-4-deoxy-
  • (2R,3R,4R,5R,6R)-2-(((2R,3S,4S,5S)-2,5-Bis(chloromethyl)-3,4-dihydroxytetrahydrofuran-2-yl)oxy)-5-chloro-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4-diol
  • (2R,3R,4R,5R,6R)-2-[(2R,3S,4S,5S)-2,5-bis(chloromethyl)-3,4-dihydroxyoxolan-2-yl]oxy-5-chloro-6-(hydroxymethyl)oxane-3,4-diol
Show all 30 synonyms
  • E955, Trichlorosucrose
  • 1,6-Dichloro-1,6-dideoxy-|A-D-fructofuranosyl-4-chloro-4-deoxy-|A-D-galactopyranoside, E955, Trichlorosucrose
  • 1,6-Dichloro-1,6-dideoxy-beta-D-fructofuranosyl 4-chloro-4-deoxy-alpha-D-galactose
  • Sucralose CRS
  • Sucralose, 1,6-Dichloro-1,6-dideoxy-beta-d-fructofuranosyl 4-chloro-4-deoxy-alpha-d-galactopyranoside

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
White to off white, crystalline powderexp.
Taste
Intensely sweet tasteexp.
Melting point
130 °Cexp.
Solubility
Freely soluble in water, methanol and ethanol, Slightly soluble in ethyl acetateexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
397.64 g/molcalc.
Exact mass
396.0146 Dacalc.
LogP (octanol/water)
-1.66calc.
Topological polar surface area
128.8 Ųcalc.
Hydrogen bond donors
5calc.
Hydrogen bond acceptors
8calc.
Rotatable bonds
5calc.
Heavy atoms
23calc.
Rings
2calc.
Aromatic rings
0calc.
Fraction sp3 carbons
1calc.
Formal charge
0calc.
Stereocentres
9calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1CCC(OC2CCCO2)OC1

C1CCC(OC2CCCO2)OC1

2 rings, 12 atoms, the Tetrahydro-2-((tetrahydro-2-furanyl)oxy)-2H-pyran ring system.

213 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Sucralose suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 269 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

269 suppliers in 36 countries

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Sucralose price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Flavor enhancer.

Add sweetness with or without the extra calories ... (in) beverages, baked goods, confections, table-top sugar, substitutes, many processed foods.

Non-nutritive sweetener.

Use classes: Food additives.

Cosmetic ingredient, INCI name SUCRALOSE(skin conditioning)

Pharmacological actions

  • Sweetening Agents

Roles

  • additive
  • environmental contaminant
  • flavouring agent
  • food additive
  • food component
  • hypoglycemic agent
  • pharmaceutical
  • physiological role
  • sweetening agent
  • xenobiotic

Functional uses

  • Flavouring and nutrient
  • Fragrance
  • Softener and conditioner

Cosmetic functions

  • Skin conditioning

How it is made

The starting material for the synthesis of sucralose is sucrose. The production route commonly described blocks the three primary hydroxyl groups as trityl ethers, and transforms the secondary hydroxyl groups to acetates to yield 6,1',6'-tritrityl-2,3,4,3',4'- pentaacetylsucrose. By deblocking the primary hydroxyl groups, 2,3,4,3',4'-pentaacetylsucrose is obtained. Under appropriate conditions, this compound can be transformed to 2,3,6,3',4'- pentaacetylsucrose. Chlorination at the exposed hydroxyl groups gives 4,1',6'-trichloro-4,1',6'- tridesoxygalactosucrose on conversion of the glucose moiety to galactose. Removal of the acetate groups by hydrolysis yields sucralose.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory
  • Active ingredient in FDA approved drug labels
  • Food additive

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Sucralose is traded under.

HS 2932.14Exact HS code

Heterocyclic compounds: with oxygen hetero-atom(s) only, containing an unfused furan ring (whether…

World exports in 2024
$553M
+1.7% vs 2023, imports $528M
2019 to 2024
Top exporters
  1. China51.0%
  2. United States30.4%
  3. Netherlands6.1%
Top importers
  1. United States19.6%
  2. Mexico11.2%
  3. Netherlands7.1%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Sucralose is indicative (it was matched by name in the HS nomenclature). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Sucralose, based on the data on this page

What is Sucralose?

Sucralose is a disaccharide derivative consisting of 4-chloro-4-deoxy-alpha-D-galactopyranose and 1,6-dichloro-1,6-dideoxy-beta-D-fructofuranose units linked by a glycosidic bond. It has a role as a xenobiotic, a sweetening agent and an environmental contaminant.

What is the CAS number of Sucralose?

The CAS registry number of Sucralose is 56038-13-2.

What is the molecular formula and weight of Sucralose?

The molecular formula of Sucralose is C12H19Cl3O8 and its molar mass is 397.64 g/mol.

What is Sucralose used for?

Flavor enhancer. Add sweetness with or without the extra calories ... (in) beverages, baked goods, confections, table-top sugar, substitutes, many processed foods. Non-nutritive sweetener. Use classes: Food additives.

Is Sucralose hazardous?

No GHS hazard classification for Sucralose is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Sucralose?

Sucralose is usually classified under HS code 293214 (Sucralose). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Sucralose?

CompoundList lists 269 suppliers of Sucralose in China, United States, India, Canada and 32 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Sucralose in India?

37 suppliers in India list Sucralose on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Sucralose?

Suppliers quote Sucralose on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Sucralose

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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