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Screening compounds

Supinoxin

Also known as P-P68 inhibitor RX-5902, 4-(3,5-dimethoxyphenyl)-N-(7-fluoro-3-methoxy-quinoxalin-2-yl)piperazine-1-carboxamide, 1-Piperazinecarboxamide, 4-(3,5-dimethoxyphenyl)-N-(7-fluoro-3-methoxy-2-quinoxalinyl)-

CAS 888478-45-3Formula C22H24FN5O4Molar mass 441.46 g/mol
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Supinoxin chemical structure, C22H24FN5O4, CAS 888478-45-3
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
888478-45-3
Formula
C22H24FN5O4
Molar mass
441.46 g/mol
HS code
293359
Category
Screening compounds

What is Supinoxin?

Plain description, key identifiers and synonyms

Supinoxin is an orally bioavailable small molecule inhibitor of phosphorylated-p68 RNA helicase (P-p68), with potential anti-proliferative and antineoplastic activity. Upon oral administration, supinoxin may both inhibit the activity of the anti-apoptotic B-cell lymphoma 2 (Bcl-2) protein and facilitate the induction of cyclin-dependent kinase inhibitor 1 (p21). This may prevent G2/M cell cycle progression and lead to growth inhibition in tumor cells. P-p68 is overexpressed in various types of solid tumors but absent in normal tissues, and plays a role in tumor progression and metastasis. p21 is a potent cyclin-dependent kinase inhibitor which regulates cell cycle progression and mediates both growth arrest and cellular senescence.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-(3,5-dimethoxyphenyl)-N-(7-fluoro-3-methoxyquinoxalin-2-yl)piperazine-1-carboxamide
CAS number
888478-45-3
Molecular formula
C22H24FN5O4
UNII
ZU8OM8V5WF
InChIKey
KAKPGJJRYRYSTP-UHFFFAOYSA-N
InChI
InChI=1S/C22H24FN5O4/c1-30-16-11-15(12-17(13-16)31-2)27-6-8-28(9-7-27)22(29)26-20-21(32-3)25-18-5-4-14(23)10-19(18)24-20/h4-5,10-13H,6-9H2,1-3H3,(H,24,26,29)
SMILES (canonical and isomeric)
COC1=CC(=CC(=C1)N2CCN(CC2)C(=O)NC3=NC4=C(C=CC(=C4)F)N=C3OC)OC

Synonyms

  • P-P68 inhibitor RX-5902
  • 4-(3,5-dimethoxyphenyl)-N-(7-fluoro-3-methoxy-quinoxalin-2-yl)piperazine-1-carboxamide
  • 1-Piperazinecarboxamide, 4-(3,5-dimethoxyphenyl)-N-(7-fluoro-3-methoxy-2-quinoxalinyl)-
  • 1-(3,5-Dimethoxyphenyl)-4-((6-fluoro-2-methoxyquinoxalin-3-yl)aminocarbonyl) piperazine
  • 4-(3,5-dimethoxyphenyl)-N-(7-fluoro-3-methoxyquinoxalin-2-yl)piperazine-1-carboxamide
  • Supinoxin?
  • rx-5902 (Supinoxin)
  • 1-(3,5-Dimethoxyphenyl)-4-((6-
  • 1-(3,5-dimethoxyphenyl)-4-((6-fluoro-2-methoxyquinoxalin-3-yl)aminocarbonyl)piperazine
  • 1-[(6-Fluoro-2-methoxyquinoxalin-3-yl)aminocarbonyl]-4-(3,5-dimethoxyphenyl)piperazine

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
441.46 g/molcalc.
Exact mass
441.1812 Dacalc.
LogP (octanol/water)
3.15calc.
Topological polar surface area
89.05 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
7calc.
Rotatable bonds
5calc.
Heavy atoms
32calc.
Rings
4calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.32calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(Nc1cnc2ccccc2n1)N1CCN(c2ccccc2)CC1

O=C(Nc1cnc2ccccc2n1)N1CCN(c2ccccc2)CC1

4 rings, 25 atoms.

2 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Supinoxin suppliers

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Supinoxin price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antineoplastic agent
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Supinoxin is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Supinoxin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Supinoxin, based on the data on this page

What is Supinoxin?

Supinoxin is an orally bioavailable small molecule inhibitor of phosphorylated-p68 RNA helicase (P-p68), with potential anti-proliferative and antineoplastic activity.

What is the CAS number of Supinoxin?

The CAS registry number of Supinoxin is 888478-45-3.

What is the molecular formula and weight of Supinoxin?

The molecular formula of Supinoxin is C22H24FN5O4 and its molar mass is 441.46 g/mol.

What is Supinoxin used for?

Known uses and roles of Supinoxin include building blocks in research and laboratory, screening compounds in research and laboratory, antineoplastic agent and pharmaceutical.

Is Supinoxin hazardous?

No GHS hazard classification for Supinoxin is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Supinoxin?

Supinoxin is usually classified under HS code 293359 (Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Supinoxin?

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What is the price of Supinoxin?

Suppliers quote Supinoxin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Supinoxin

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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