Suramin
Also known as Suramine, Fourneau, Farma
Key facts
What buyers check first
- CAS number
- 145-63-1
- Formula
- C51H40N6O23S6
- Molar mass
- 1,297.30 g/mol
- EC number
- 205-658-4
- HS code
- 292421
- Category
- Antibiotics and anti-infectives
What is Suramin?
Plain description, key identifiers and synonyms
Suramin is a member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years. It has a role as an antinematodal drug, an antineoplastic agent, a trypanocidal drug, an EC 2.7.11.13 (protein kinase C) inhibitor, a GABA-gated chloride channel antagonist, an angiogenesis inhibitor, a GABA antagonist, a ryanodine receptor agonist, an apoptosis inhibitor and a purinergic receptor P2 antagonist. It is a member of phenylureas, a secondary carboxamide and a naphthalenesulfonic acid. It is functionally related to a naphthalene-1,3,5-trisulfonic acid. It is a conjugate acid of a suramin(6-).
Identifiers
Registry numbers, names and line notations, tap to copy
- IUPAC name
- 8-[[4-methyl-3-[[3-[[3-[[2-methyl-5-[(4,6,8-trisulfonaphthalen-1-yl)carbamoyl]phenyl]carbamoyl]phenyl]carbamoylamino]benzoyl]amino]benzoyl]amino]naphthalene-1,3,5-trisulfonic acid
- CAS number
- 145-63-1 CAS number cross-checkedOther or deprecated CAS: 129-46-4
- EC number
- 205-658-4
- Molecular formula
- C51H40N6O23S6
- UNII
- 6032D45BEM
- InChIKey
- FIAFUQMPZJWCLV-UHFFFAOYSA-N
- InChI
- InChI=1S/C51H40N6O23S6/c1-25-9-11-29(49(60)54-37-13-15-41(83(69,70)71)35-21-33(81(63,64)65)23-43(45(35)37)85(75,76)77)19-39(25)56-47(58)27-5-3-7-31(17-27)52-51(62)53-32-8-4-6-28(18-32)48(59)57-40-20-30(12-10-26(40)2)50(61)55-38-14-16-42(84(72,73)74)36-22-34(82(66,67)68)24-44(46(36)38)86(78,79)80/h3-24H,1-2H3,(H,54,60)(H,55,61)(H,56,58)(H,57,59)(H2,52,53,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80)
- SMILES (canonical and isomeric)
- CC1=C(C=C(C=C1)C(=O)NC2=C3C(=CC(=CC3=C(C=C2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)NC(=O)C4=CC(=CC=C4)NC(=O)NC5=CC=CC(=C5)C(=O)NC6=C(C=CC(=C6)C(=O)NC7=C8C(=CC(=CC8=C(C=C7)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)C
Synonyms
- Suramine
- Fourneau
- Farma
- Belganyl
- Metaret
- FARMA-939
- 1,3,5-naphthalenetrisulfonic acid, 8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-
- 1,3,5-Naphthalenetrisulfonic acid, 8,8'-(carbonylbis(imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino))bis-
- 8,8'-(Carbonylbis(imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino))bis-1,3,5-naphthalenetrisulfonic acid
- 8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic acid
- Monosodium Salt Suramin
- Salt Suramin, Monosodium
- Naganol
- Naphuride
- Farma 939
- Suramine sodium
- m,m'-Ureylen-bis-(8-(m-(benzamido)-p-toluamido)naphthalin-1,3,5-trisulfonsaeure)
- Harnstoff, symmetischer der 3-aminobenzoyl-3-amino-4-methylbenzoyl-1-naphthylamin-4,6,8-trisulfonsaeure
- Carbanilide, 3,3'-bis((5-((4,6,8-trisulfo-1-naphthyl)carbamoyl)-o-tolyl)carbamoyl)-
- 8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bisnaphthalene-1,3,5-trisulphonic acid
- Naganil
- 8,8'-(Carbonylbis(imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino))bisnaphthalene-1,3,5-trisulphonic acid
- Naganol 6 Na
- 8,8'-((3,3'-((3,3'-(Carbonylbis(azanediyl))bis(benzoyl))bis(azanediyl))bis(4-methylbenzoyl))bis(azanediyl))bis(naphthalene-1,3,5-trisulfonic acid)
- 8,8'-[Ureylenebis[m-phenylenecarbonylimino(4-methyl-m-phenylene)carbonylimino]]di-1,3,5-naphthalenetrisulfonic acid
Show all 34 synonymsShow fewer synonyms
- SGCTO-001
- 8,8'-(Ureylenebis(m-phenylenecarbonylimino(4-methyl-m-phenylene)carbonylimino))di-1,3,5-naphthalenetrisulfonic acid
- US8835659, Suramin
- 3-14-00-02267 (Beilstein Handbook Reference)
- DivK1c_006758
- sym-bis(m-aminobenzoyl-m-amino-p-methylbenzoyl-1-napthylamino-4,6,8-trisulfonate) carbamide
- 1,3,5-Naphthylenetrisulfonic acid, 8,8'-(ureylenebis(m-phenylenecarbonylimino(4-methyl-m-phenylene)carbonylimino))di-
- 8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonyl-imino]]bis-1,3,5-naphthalenetrisulfonic acid
- 8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonyl-imino]]bis-1,3,5-napthalenetrisulfonic acid
Physical and chemical properties
Measured values and descriptors computed from the structure
Physical and chemical properties
Measured values, check the supplier specification for your grade
No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.
Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.
Computed descriptors
Calculated from the structure, useful for screening and formulation
| Molecular weight | 1,297.30 g/molcalc.Computed value |
|---|---|
| Exact mass | 1,296.0469 Dacalc.Computed value |
| LogP (octanol/water) | 6.74calc.Computed value |
| Topological polar surface area | 483.8 Ųcalc.Computed value |
| Hydrogen bond donors | 12calc.Computed value |
| Hydrogen bond acceptors | 17calc.Computed value |
| Rotatable bonds | 16calc.Computed value |
| Heavy atoms | 86calc.Computed value |
| Rings | 8calc.Computed value |
| Aromatic rings | 8calc.Computed value |
| Fraction sp3 carbons | 0.04calc.Computed value |
| Formal charge | 0calc.Computed value |
| Stereocentres | 0calc.Computed value |
| Lipinski rule of five | Fails (4 violations)calc.Computed value |
Calculated for screening. Confirm critical figures with the supplier.
Murcko scaffold
The ring system that remains when every side chain is removed
O=C(Nc1cccc(C(=O)Nc2cccc(C(=O)Nc3cccc4ccccc34)c2)c1)Nc1cccc(C(=O)Nc2cccc(C(=O)Nc3cccc4ccccc34)c2)c1
8 rings, 60 atoms.
10 other chemicals share this scaffoldSafety and hazards
GHS classification summary, not a safety data sheet
No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.
GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.
Suramin suppliers
Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings
- Price on request
- Price on request
- Price on request
- Hong Kong, Hong KongUnclaimed profileSuraminGrade, purity and minimum order on requestPrice on request
- China, ChangshaUnclaimed profileSuraminGrade, purity and minimum order on requestPrice on request
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Where suppliers are based
8 suppliers in 5 countries
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Suramin price
Indicative price range per kg from live supplier offers
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Uses and applications
What the substance is used for, by industry and function
Industries and functions
Pharmacological actions
- Antinematodal Agents
- Antineoplastic Agents
- Trypanocidal Agents
Roles
- GABA agent
- GABA antagonist
- GABA-gated chloride channel antagonist
- angiogenesis inhibitor
- antagonist
- anthelminthic drug
- antiinfective agent
- antimicrobial agent
- antimicrobial drug
- antinematodal drug
- antineoplastic agent
- antiparasitic agent
- antiprotozoal drug
- apoptosis inhibitor
- biophysical role
- enzyme inhibitor
- membrane transport modulator
- nematicide
- neurotransmitter agent
- pesticide
- pharmaceutical
- purinergic receptor P2 antagonist
- ryanodine receptor agonist
- trypanocidal drug
Pharmacology
Suramin is a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth factor I (IGF-I), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and tumor growth factor-beta (TGF-beta), to their receptors, thereby inhibiting endothelial cell proliferation and migration. This agent also inhibits vascular endothelial growth factor (VEGF)- and basic fibroblast growth factor (bFGF)-induced angiogenesis, retroviral reverse transcriptase, uncoupling of G-proteins from receptors, topoisomerases, cellular folate transport, and steroidogenesis. (NCI04)
Regulatory status
Inventories, regulations and trade controls that list this substance
No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.
HS code and trade data
Customs classification and reported world trade statistics
Global trade
World import and export statistics for the HS code Suramin is traded under.
Ureines and their derivatives, salts thereof
The HS code shown for Suramin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.
Related chemicals
Parent and salt forms, stereoisomers, similar structures and isomers
Salt and hydrate forms
Records that share this compound as their parent
Same formula isomers
Different compounds that share this molecular formula
Frequently asked questions
Quick answers about Suramin, based on the data on this page
What is Suramin?
What is the CAS number of Suramin?
What is the molecular formula and weight of Suramin?
What is Suramin used for?
Is Suramin hazardous?
What is the HS code of Suramin?
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What is the price of Suramin?
Guides for buyers
Practical guides that help when you source, ship or handle Suramin
- Article, QualityPharma grades explained: IP vs BP vs USP vs EPWhat the Indian, British, US and European pharmacopoeias are, how their monographs differ, what multi grade claims mean and why a grade alone does not make a product fit for medicines.Read
- Article, SourcingHow to write an RFQ that gets fast and accurate quotesWhat suppliers need to quote quickly and comparably: exact product identity, quantity and packing, delivery terms, documents, samples and payment, with a ready to use template.Read
- Guide, Trade and logisticsHS codes for chemicals and why they matterHow the Harmonized System classifies chemicals, the chapters that matter, the rules for chemically defined compounds and mixtures, and practical steps to find the right code.Read
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