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Screening compounds

Tambiciclib

Also known as 4-(((4-(5-Chloro-2-((trans-4-(((R)-1-methoxypropan-2-yl)amino)cyclohexyl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile, Tambiciclib (USAN/INN), SLS 009

CAS 2247481-08-7Formula C25H35ClN6O2SMolar mass 519.12 g/mol
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Tambiciclib chemical structure, C25H35ClN6O2S, CAS 2247481-08-7
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
2247481-08-7
Formula
C25H35ClN6O2S
Molar mass
519.12 g/mol
HS code
293410
Category
Screening compounds

What is Tambiciclib?

Plain description, key identifiers and synonyms

Tambiciclib is a selective inhibitor of the serine/threonine cyclin-dependent kinase 9 (CDK9), the catalytic subunit of the RNA polymerase II (RNA Pol II) elongation factor positive transcription elongation factor b (PTEF-b, PTEFb), with potential antineoplastic activity. Upon administration, tambiciclib targets, binds to and blocks the phosphorylation and kinase activity of CDK9, thereby preventing PTEFb-mediated activation of RNA Pol II, leading to the inhibition of gene transcription of various anti-apoptotic proteins. This induces cell cycle arrest and apoptosis and prevents tumor cell proliferation. CDK9 regulates elongation of transcription through phosphorylation of RNA Pol II at serine 2 (p-Ser2-RNAPII). It is upregulated in various tumor cell types and plays a key role in the regulation of Pol II-mediated transcription of anti-apoptotic proteins. Tumor cells are dependent on anti-apoptotic proteins for their survival.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-[[[4-[5-chloro-2-[[4-[[(2R)-1-methoxypropan-2-yl]amino]cyclohexyl]amino]-4-pyridinyl]-1,3-thiazol-2-yl]amino]methyl]oxane-4-carbonitrile
CAS number
2247481-08-7
Molecular formula
C25H35ClN6O2S
UNII
XDZ7VK8CXC
InChIKey
PGVNLOUNSPQGJP-LMDPOFIKSA-N
InChI
InChI=1S/C25H35ClN6O2S/c1-17(13-33-2)30-18-3-5-19(6-4-18)31-23-11-20(21(26)12-28-23)22-14-35-24(32-22)29-16-25(15-27)7-9-34-10-8-25/h11-12,14,17-19,30H,3-10,13,16H2,1-2H3,(H,28,31)(H,29,32)/t17-,18?,19?/m1/s1
Canonical SMILES
COCC(C)NC1CCC(Nc2cc(-c3csc(NCC4(C#N)CCOCC4)n3)c(Cl)cn2)CC1
Isomeric SMILES
C[C@H](COC)NC1CCC(CC1)NC2=NC=C(C(=C2)C3=CSC(=N3)NCC4(CCOCC4)C#N)Cl

Synonyms

  • 4-(((4-(5-Chloro-2-((trans-4-(((R)-1-methoxypropan-2-yl)amino)cyclohexyl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile
  • Tambiciclib (USAN/INN)
  • SLS 009
  • 2H-Pyran-4-carbonitrile, 4-[[[4-[5-chloro-2-[[trans-4-[[(1R)-2-methoxy-1-methylethyl]amino]cyclohexyl]amino]-4-pyridinyl]-2-thiazolyl]amino]methyl]tetrahydro-
  • 4-[[[4-[5-Chloro-2-[[trans-4-[[(1R)-2-methoxy-1-methylethyl]amino]cyclohexyl]amino]-4-pyridinyl]-2-thiazolyl]amino]methyl]tetrahydro-2H-pyran-4-carbonitrile

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
519.12 g/molcalc.
Exact mass
518.2231 Dacalc.
LogP (octanol/water)
4.94calc.
Topological polar surface area
104.1 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
9calc.
Rotatable bonds
10calc.
Heavy atoms
35calc.
Rings
4calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.64calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1cc(-c2csc(NCC3CCOCC3)n2)cc(NC2CCCCC2)n1

c1cc(-c2csc(NCC3CCOCC3)n2)cc(NC2CCCCC2)n1

4 rings, 26 atoms.

4 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Tambiciclib suppliers

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Tambiciclib price

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Uses and applications

What the substance is used for, by industry and function

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Tambiciclib is traded under.

HS 2934.10Indicative HS code

Compounds containing an unfused thiazole ring (whether or not hydrogenated) in the…

World exports in 2024
$3.88B
−16.1% vs 2023, imports $3.12B
2019 to 2024
Top exporters
  1. Switzerland * partner reported36.4%
  2. Ireland28.8%
  3. China10.0%
Top importers
  1. Canada33.4%
  2. United States14.4%
  3. Ireland13.1%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Tambiciclib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Tambiciclib, based on the data on this page

What is Tambiciclib?

Tambiciclib is a selective inhibitor of the serine/threonine cyclin-dependent kinase 9 (CDK9), the catalytic subunit of the RNA polymerase II (RNA Pol II) elongation factor positive transcription elongation factor b (PTEF-b, PTEFb), with potential antineoplastic activity.

What is the CAS number of Tambiciclib?

The CAS registry number of Tambiciclib is 2247481-08-7.

What is the molecular formula and weight of Tambiciclib?

The molecular formula of Tambiciclib is C25H35ClN6O2S and its molar mass is 519.12 g/mol.

What is Tambiciclib used for?

Known uses and roles of Tambiciclib include building blocks in research and laboratory and screening compounds in research and laboratory.

Is Tambiciclib hazardous?

No GHS hazard classification for Tambiciclib is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Tambiciclib?

Tambiciclib is usually classified under HS code 293410 (Compounds containing an unfused thiazole ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Tambiciclib?

Post a free request on CompoundList and suppliers of Tambiciclib will send you quotes. Your contact details stay private until you accept a quote.

What is the price of Tambiciclib?

Suppliers quote Tambiciclib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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