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Impurities and reference standards

Tcmdc-123784

Also known as N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine, N-(3-chloro-4-fluorophenyl)-6-nitro-4-quinazolinamine, Dacomitinib Impurity 59

CAS 184356-50-1Formula C14H8ClFN4O2Molar mass 318.70 g/molEC 123-825-9
GHS signal word: Warning. Pictograms: Harmful or irritant
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Tcmdc-123784 chemical structure, C14H8ClFN4O2, CAS 184356-50-1
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
184356-50-1
Formula
C14H8ClFN4O2
Molar mass
318.70 g/mol
EC number
123-825-9
HS code
293359
Category
Impurities and reference standards

What is Tcmdc-123784?

Plain description, key identifiers and synonyms

Tcmdc-123784 is a chemical substance with the molecular formula C14H8ClFN4O2 and a molar mass of 318.70 g/mol. Its CAS registry number is 184356-50-1. The IUPAC name is N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine
CAS number
184356-50-1 CAS number cross-checked
EC number
123-825-9
Molecular formula
C14H8ClFN4O2
MDL number
MFCD03932047
InChIKey
OXLCCXLHESAETR-UHFFFAOYSA-N
InChI
InChI=1S/C14H8ClFN4O2/c15-11-5-8(1-3-12(11)16)19-14-10-6-9(20(21)22)2-4-13(10)17-7-18-14/h1-7H,(H,17,18,19)
SMILES (canonical and isomeric)
C1=CC(=C(C=C1NC2=NC=NC3=C2C=C(C=C3)[N+](=O)[O-])Cl)F

Synonyms

  • N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine
  • N-(3-chloro-4-fluorophenyl)-6-nitro-4-quinazolinamine
  • Dacomitinib Impurity 59
  • C14H8ClFN4O2
  • N-(3-chloro-4-fluoro-phenyl)-6-nitro-quinazolin-4-amine
  • 4-[N-(3-Chloro-4-fluorophenyl)amino]-6-nitroquinazoline
  • (3-chloro-4-fluoro-phenyl)-(6-nitro-quinazolin-4-yl)-amine

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
318.70 g/molcalc.
Exact mass
318.032 Dacalc.
LogP (octanol/water)
4.07calc.
Topological polar surface area
80.95 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
3calc.
Heavy atoms
22calc.
Rings
3calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(Nc2ncnc3ccccc23)cc1

c1ccc(Nc2ncnc3ccccc23)cc1

3 rings, 17 atoms, the 4-Anilinoquinazoline ring system.

635 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
  • H319Causes serious eye irritation.
  • H413May cause long lasting harmful effects to aquatic life.
Precautionary statements (10)
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P330Rinse mouth.
  • P337 + P317If eye irritation persists: Get medical help.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Tcmdc-123784 suppliers

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Tcmdc-123784 price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Applications are not documented for this substance yet. Suppliers often describe uses on their product pages, linked in the suppliers list above.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Tcmdc-123784 is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Tcmdc-123784 is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Tcmdc-123784, based on the data on this page

What is Tcmdc-123784?

Tcmdc-123784 is a chemical substance with the molecular formula C14H8ClFN4O2 and a molar mass of 318.70 g/mol. Its CAS registry number is 184356-50-1. The IUPAC name is N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine.

What is the CAS number of Tcmdc-123784?

The CAS registry number of Tcmdc-123784 is 184356-50-1.

What is the molecular formula and weight of Tcmdc-123784?

The molecular formula of Tcmdc-123784 is C14H8ClFN4O2 and its molar mass is 318.70 g/mol.

Is Tcmdc-123784 hazardous?

Tcmdc-123784 carries the GHS signal word "Warning". Main hazards: harmful if swallowed, causes serious eye irritation, may cause long lasting harmful effects to aquatic life. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Tcmdc-123784?

Tcmdc-123784 is usually classified under HS code 293359 (Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Tcmdc-123784?

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What is the price of Tcmdc-123784?

Suppliers quote Tcmdc-123784 on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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