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Screening compounds

Teglarinad

Also known as Teglarinad ion, Teglarinad cation, 4-((N'-(6-(4-Chlorophenoxy)hexyl))-N''-cyanocarbamimidamido)-1-(3-oxo-2,4,7,10,13,16-hexaoxaheptadecyl)pyridin-1-ium

CAS 766501-75-1Formula C30H43ClN5O8+Molar mass 637.15 g/mol
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Teglarinad chemical structure, C30H43ClN5O8+, CAS 766501-75-1
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
766501-75-1
Formula
C30H43ClN5O8+
Molar mass
637.15 g/mol
HS code
293339
Category
Screening compounds

What is Teglarinad?

Plain description, key identifiers and synonyms

Teglarinad is a water-soluble prodrug of a pyridyl cyanoguanidine compound and an inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) with potential antineoplastic activity. Teglarinad is rapidly converted in the bloodstream into an active compound through hydrolytic cleavage of the carbonate ester bond. The activated form inhibits NAMPT, thereby inhibiting nicotinamide adenine dinucleotide (NAD+) biosynthesis and induces a rapid decline in intracellular NAD+ followed by ATP reduction. As NAD+ is essential for tumor cell growth, inhibition of NAMPT induces tumor cell death. NAMPT is an essential enzyme in the synthesis of NAD+ and is upregulated in some cancers.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
[4-[[N'-[6-(4-chlorophenoxy)hexyl]-N-cyanocarbamimidoyl]amino]pyridin-1-ium-1-yl]methyl 2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethyl carbonate
CAS number
766501-75-1
Molecular formula
C30H43ClN5O8+
UNII
NUG9P5GWZB
InChIKey
RXXJCNMVVRGOJB-UHFFFAOYSA-O
InChI
InChI=1S/C30H42ClN5O8/c1-38-16-17-39-18-19-40-20-21-41-22-23-43-30(37)44-25-36-13-10-27(11-14-36)35-29(34-24-32)33-12-4-2-3-5-15-42-28-8-6-26(31)7-9-28/h6-11,13-14H,2-5,12,15-23,25H2,1H3,(H,33,34)/p+1
SMILES (canonical and isomeric)
COCCOCCOCCOCCOC(=O)OC[N+]1=CC=C(C=C1)NC(=NCCCCCCOC2=CC=C(C=C2)Cl)NC#N

Synonyms

  • Teglarinad ion
  • Teglarinad cation
  • 4-((N'-(6-(4-Chlorophenoxy)hexyl))-N''-cyanocarbamimidamido)-1-(3-oxo-2,4,7,10,13,16-hexaoxaheptadecyl)pyridin-1-ium
  • Pyridinium, 4-((((6-(4-chlorophenoxy)hexyl)amino)(cyanoamino)methylene)amino)-1-(3-oxo-2,4,7,10,13,16-hexaoxaheptadec-1-yl)-
  • Pyridinium, 4-[[[[6-(4-chlorophenoxy)hexyl]amino](cyanoamino)methylene]amino]-1-(3-oxo-2,4,7,10,13,16-hexaoxaheptadec-1-yl)-
  • [4-[[N'-[6-(4-chlorophenoxy)hexyl]-N-cyanocarbamimidoyl]amino]pyridin-1-ium-1-yl]methyl 2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethyl carbonate
  • PyridiniuM, 4-[[[[6-(4-chlorophenoxy)hexyl]iMino](cyanoaMino)Methyl]aMino]-1-(3-oxo-2,4,7,10,13,16-hexaoxaheptadec-1-yl)-
  • Pyridinium,4-[[[[6-(4-chlorophenoxy)hexyl]imino](cyanoamino)methyl]amino]-1-(3-oxo-2,4,7,10,13,16-hexaoxaheptadec-1-yl)-
  • (Z)-4-(3-(6-(4-Chlorophenoxy)hexyl)-2-cyanoguanidino)-1-(3-oxo-2,4,7,10,13,16-hexaoxaheptadecyl)pyridin-1-ium

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
637.15 g/molcalc.
Exact mass
636.2795 Dacalc.
LogP (octanol/water)
3.91calc.
Topological polar surface area
145.8 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
10calc.
Rotatable bonds
23calc.
Heavy atoms
44calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.53calc.
Formal charge
1calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C(=NCCCCCCOc1ccccc1)Nc1ccncc1

C(=NCCCCCCOc1ccccc1)Nc1ccncc1

2 rings, 22 atoms.

5 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Teglarinad suppliers

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Teglarinad price

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Uses and applications

What the substance is used for, by industry and function

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Teglarinad is traded under.

HS 2933.39Indicative HS code

Heterocyclic compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure…

World exports in 2024
$9.16B
−17.9% vs 2023, imports $10.6B
2019 to 2024
Top exporters
  1. China21.5%
  2. India * partner reported12.3%
  3. Ireland11.6%
Top importers
  1. Germany14.2%
  2. United States12.8%
  3. Brazil10.1%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Teglarinad is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Teglarinad, based on the data on this page

What is Teglarinad?

Teglarinad is a water-soluble prodrug of a pyridyl cyanoguanidine compound and an inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) with potential antineoplastic activity. Teglarinad is rapidly converted in the bloodstream into an active compound through hydrolytic cleavage of the carbonate ester bond.

What is the CAS number of Teglarinad?

The CAS registry number of Teglarinad is 766501-75-1.

What is the molecular formula and weight of Teglarinad?

The molecular formula of Teglarinad is C30H43ClN5O8+ and its molar mass is 637.15 g/mol.

What is Teglarinad used for?

Known uses and roles of Teglarinad include building blocks in research and laboratory and screening compounds in research and laboratory.

Is Teglarinad hazardous?

No GHS hazard classification for Teglarinad is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Teglarinad?

Teglarinad is usually classified under HS code 293339 (Compounds containing an unfused pyridine ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Teglarinad?

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What is the price of Teglarinad?

Suppliers quote Teglarinad on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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