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Silanes and silicones

Tetramethoxysilane

Also known as Tetramethyl orthosilicate, Tetramethyl silicate, Methyl silicate

CAS 681-84-5Formula C4H12O4SiMolar mass 152.22 g/molEC 211-656-4
GHS signal word: Danger. Pictograms: Flammable, Corrosive, Acute toxicity (severe), Harmful or irritant 31 suppliers listed
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Tetramethoxysilane chemical structure, C4H12O4Si, CAS 681-84-5
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Colorless liquid
Melting point
-1 °C
Boiling point
121 °C
Density
1.0232 g/cm³ at 20 °C
Flash point
20 °C
HS code
292090
Category
Silanes and silicones
UN number
UN 2606
Illustrative photo, a 1000 litre IBC tote of clear liquid in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Tetramethoxysilane?

Plain description, key identifiers and synonyms

Methyl orthosilicate appears as a clear colorless liquid. Flash point below 125 °F. Less dense than water and insoluble in water. Very toxic by ingestion and inhalation and very irritating to skin and eyes. Used to make paints and lacquers.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
tetramethyl silicate
CAS number
681-84-5 CAS number cross-checked
EC number
211-656-4
Molecular formula
C4H12O4Si
UNII
19D35VPL66
MDL number
MFCD00008341
InChIKey
LFQCEHFDDXELDD-UHFFFAOYSA-N
InChI
InChI=1S/C4H12O4Si/c1-5-9(6-2,7-3)8-4/h1-4H3
SMILES (canonical and isomeric)
CO[Si](OC)(OC)OC

Synonyms

  • Tetramethyl orthosilicate
  • Tetramethyl silicate
  • Methyl silicate
  • TMOS
  • Methyl Silicate 39
  • Silane, tetramethoxy-
  • Methyl silicate 28
  • Tetramethylsilikat
  • Methyl silicate ((MeO)4Si)
  • TL 190
  • Methyl silicate ((CH3)4SiO4)
  • Silicic acid, methyl ester of ortho-
  • TSL 8114
  • Silicic acid (H4SiO4), tetramethyl ester
  • SIT 7510.0
  • MSP 150
  • silicic acid tetramethyl ester
  • Methyl orthosilicate
  • Silicic acid, tetramethyl ester
  • Methyl silicate 51
  • tetramethylorthosilicate
  • Tetra-methyl orthosilicate
  • Methyl silicate 56
  • C4H12O4Si
  • Methyl silicate, ((MeO)4Si)
Show all 36 synonyms
  • Dynasil M
  • tetramethoxy silane
  • tetramethoxy-silane
  • tetramethylortho silicate
  • tetramethylortho-silicate
  • Si(OMe)4
  • Si(OCH3)4
  • Tetramethyl orthosilicate, 98%
  • Tetramethyl ester silicate
  • Tetramethyl orthosilicate, >=99%
  • UN 2606

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Colorless liquidexp.
Melting point
-1 °Cexp.
Boiling point
121 °Cexp.
Density
1.0232 g/cm³ at 20 °Cexp.
Flash point
20 °Cexp.
Solubility
Not soluble in waterexp.
Vapour pressure
16.5 mm Hg at 20 °C (2.2 kPa)exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
152.22 g/molcalc.
Exact mass
152.0505 Dacalc.
LogP (octanol/water)
0.01calc.
Topological polar surface area
36.92 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
4calc.
Heavy atoms
9calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
1calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS02: Flammable
Flammable
GHS05: Corrosive
Corrosive
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard
331NFPA 704 rating

Hazard statements

  • H226Flammable liquid and vapour.
  • H315Causes skin irritation.
  • H318Causes serious eye damage.
  • H330Fatal if inhaled.
  • H335May cause respiratory irritation.
  • H372Causes damage to organs through prolonged or repeated exposure.
Precautionary statements (30)
  • P210Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
  • P233Keep container tightly closed.
  • P240Ground and bond container and receiving equipment.
  • P241Use explosion-proof electrical, ventilating and lighting equipment.
  • P242Use non-sparking tools.
  • P243Take action to prevent static discharges.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P284In case of inadequate ventilation wear respiratory protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P303 + P361 + P353If on skin (or hair): Take off immediately all contaminated clothing. Rinse skin with water or shower.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P354 + P338If in eyes: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P316Get emergency medical help immediately.
  • P317Get medical help.
  • P319Get medical help if you feel unwell.
  • P320Specific treatment is urgent (see supplemental first aid instructions on the label).
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P370 + P378In case of fire: Use appropriate media to extinguish.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P403 + P235Store in a well-ventilated place. Keep cool.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.
UN number
UN 2606
Transport hazard class
6.1
Packing group
I

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Tetramethoxysilane suppliers

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All 31 suppliers
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Where suppliers are based

31 suppliers in 7 countries

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Tetramethoxysilane price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Methyl silicate has been used in the ceramic industry for closing pores, including those in concrete and cement, for coating metal surfaces and as a bonding agent in paints and lacquers.

In coating picture screens of television picture tubes.

Used in the glass frosting process.

Used in the sol-gel synthesis of chromium-doped silicates and in the formation of hexagonal mesoporous silica layers.

Industrial uses: Intermediate.

Functional uses

  • Chemical reaction regulator
  • Viscosity modifier

Regulatory status

Inventories, regulations and trade controls that list this substance

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Tetramethoxysilane is traded under.

HS 2920.90Indicative HS code

Esters, other than thiophosphoric esters (phosphorothioates) and phosphite esters and their salts…

World exports in 2024
$1.05B
+8.0% vs 2023, imports $1.23B
2019 to 2024
Top exporters
  1. China33.4%
  2. Germany18.8%
  3. United States12.4%
Top importers
  1. United States19.2%
  2. Singapore8.9%
  3. South Korea6.9%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Tetramethoxysilane is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Tetramethoxysilane, based on the data on this page

What is Tetramethoxysilane?

Methyl orthosilicate appears as a clear colorless liquid. Flash point below 125 °F. Less dense than water and insoluble in water. Very toxic by ingestion and inhalation and very irritating to skin and eyes. Used to make paints and lacquers.

What is the CAS number of Tetramethoxysilane?

The CAS registry number of Tetramethoxysilane is 681-84-5.

What is the molecular formula and weight of Tetramethoxysilane?

The molecular formula of Tetramethoxysilane is C4H12O4Si and its molar mass is 152.22 g/mol.

What is Tetramethoxysilane used for?

Methyl silicate has been used in the ceramic industry for closing pores, including those in concrete and cement, for coating metal surfaces and as a bonding agent in paints and lacquers. In coating picture screens of television picture tubes. Used in the glass frosting process.

Is Tetramethoxysilane hazardous?

Tetramethoxysilane carries the GHS signal word "Danger". Main hazards: flammable liquid and vapour, causes skin irritation, causes serious eye damage. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Tetramethoxysilane?

Tetramethoxysilane is usually classified under HS code 292090 (Esters of other inorganic acids of non-metals (excluding esters of hydrogen halides) and…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Tetramethoxysilane?

CompoundList lists 31 suppliers of Tetramethoxysilane in China, United States, Germany, Netherlands and 3 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Tetramethoxysilane?

Suppliers quote Tetramethoxysilane on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Tetramethoxysilane

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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