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Organometallic compounds

Tetramethyllead

Also known as Tetramethylplumbane, Plumbane, tetramethyl-, Tetramethyl lead

CAS 75-74-1Formula C4H12PbMolar mass 267.34 g/molEC 200-897-0
GHS signal word: Danger. Pictograms: Flammable, Acute toxicity (severe), Harmful or irritant, Serious health hazard Controlled, licensed buyers only
Request as a licensed buyer Safety data
Tetramethyllead chemical structure, C4H12Pb, CAS 75-74-1
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Colorless liquid (/often/ dyed red, orange, or blue /for use in coimmercial gasoline/)
Melting point
-30.2 °C
Boiling point
110 °C
Density
1.995 g/cm³ at 20 °C
Flash point
37.8 °C
HS code
293110
Category
Organometallic compounds
UN number
UN 1649

What is Tetramethyllead?

Plain description, key identifiers and synonyms

Tetramethyllead is an organolead compound. It has a role as a NMR chemical shift reference compound.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
tetramethylplumbane
CAS number
75-74-1 CAS number cross-checked
EC number
200-897-0
Molecular formula
C4H12Pb
UNII
C7J62Z32IW
InChIKey
XOOGZRUBTYCLHG-UHFFFAOYSA-N
InChI
InChI=1S/4CH3.Pb/h4*1H3;
SMILES (canonical and isomeric)
C[Pb](C)(C)C

Synonyms

  • Tetramethylplumbane
  • Plumbane, tetramethyl-
  • Tetramethyl lead
  • Lead, tetramethyl-
  • Lead tetramethyl
  • Tetramethylolovo
  • Piombo tetra-metile
  • Bleitetramethyl
  • PbMe4
  • Lead, tetramethyl
  • Tetramethyl lead (as Pb)
  • Tetramethyl plumbane
  • TML
  • Plumbane, tetramethyl
  • (CH3)4Pb

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Colorless liquid (/often/ dyed red, orange, or blue /for use in coimmercial gasoline/)exp.
Odour
Fruity odorexp.
Melting point
-30.2 °Cexp.
Boiling point
110 °Cexp.
Density
1.995 g/cm³ at 20 °Cexp.
Flash point
37.8 °Cexp.
Autoignition temperature
254 °Cexp.
Solubility
In water, 15 mg/L at 25 °Cexp.
Vapour pressure
26 mm Hg at 20 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
267.34 g/molcalc.
Exact mass
268.0706 Dacalc.
LogP (octanol/water)
1.95calc.
Topological polar surface area
0 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
0calc.
Rotatable bonds
0calc.
Heavy atoms
5calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
1calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS02: Flammable
Flammable
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard
GHS09: Hazardous to the environment
Hazardous to the environment
323NFPA 704 rating

Hazard statements

  • H226Flammable liquid and vapour.
  • H300 + H310 + H330Fatal if swallowed. Fatal in contact with skin. Fatal if inhaled.
  • H300Fatal if swallowed.
  • H302 + H332Harmful if swallowed. Harmful if inhaled.
  • H310Fatal in contact with skin.
  • H332Harmful if inhaled.
  • H360May damage fertility or the unborn child.
  • H373May cause damage to organs through prolonged or repeated exposure.
  • H400Very toxic to aquatic life.
  • H410Very toxic to aquatic life with long lasting effects.
Precautionary statements (35)
  • P203Obtain, read and follow all safety instructions before use.
  • P210Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
  • P233Keep container tightly closed.
  • P240Ground and bond container and receiving equipment.
  • P241Use explosion-proof electrical, ventilating and lighting equipment.
  • P242Use non-sparking tools.
  • P243Take action to prevent static discharges.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P262Do not get in eyes, on skin, or on clothing.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P284In case of inadequate ventilation wear respiratory protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P303 + P361 + P353If on skin (or hair): Take off immediately all contaminated clothing. Rinse skin with water or shower.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P316Get emergency medical help immediately.
  • P317Get medical help.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P320Specific treatment is urgent (see supplemental first aid instructions on the label).
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P361 + P364Take off immediately all contaminated clothing. And wash it before reuse.
  • P370 + P378In case of fire: Use appropriate media to extinguish.
  • P391Collect spillage.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P403 + P235Store in a well-ventilated place. Keep cool.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.
UN number
UN 1649
Transport hazard class
6.1
Packing group
I

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Tetramethyllead suppliers

Controlled substance, listings of documented suppliers only, in the documented ranking

Pic

Tetramethyllead is controlled. Only documented suppliers can list it, and buyers must upload a valid licence with their request. Every request is reviewed before suppliers see it.

Tetramethyl lead

Reference: Rotterdam Convention Annex III, prior informed consent before export

Our policy on controlled substances
No documented supplier lists it yet

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Tetramethyllead price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Antiknock additive for gasolines.

Dilute grade used for blending of gasolines used in laboratory engine testing.

Antiknock agents in aviation gasoline (Lead alkyl, mixed).

The predominant use for tetramethyl lead is as an octane improver, or anti-knock additive ... In some older engines the lead also provides an essential source of solid lubricant for the valve gear.

Roles

  • NMR chemical shift reference compound
  • additive
  • plastic additive
  • plastic stabilizer
  • reference compound
  • stabilizer

How it is made

The best known industrial process for producing tetramethyllead ... is the reaction of the sodium - lead alloy PbNa with methyl chloride...

Tetramethyllead is also manufactured by an electrolytic Grignard reaction.

Regulatory status

Inventories, regulations and trade controls that list this substance

Pic

Tetramethyllead is controlled. Only documented suppliers can list it, and buyers must upload a valid licence with their request. Every request is reviewed before suppliers see it.

Tetramethyl lead

Reference: Rotterdam Convention Annex III, prior informed consent before export

Our policy on controlled substances

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Tetramethyllead is traded under.

HS 2931.10Exact HS code

Tetramethyl lead and tetraethyl lead

World exports in 2024
$22M
+488% vs 2023, imports $19.5M
2019 to 2024
Top exporters
  1. Netherlands82.8%
  2. United Kingdom4.8%
  3. United States4.2%
Top importers
  1. France * partner reported29.7%
  2. Thailand19.5%
  3. Netherlands12.5%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Tetramethyllead is indicative (it was matched by name in the HS nomenclature). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Tetramethyllead, based on the data on this page

What is Tetramethyllead?

Tetramethyllead is an organolead compound. It has a role as a NMR chemical shift reference compound.

What is the CAS number of Tetramethyllead?

The CAS registry number of Tetramethyllead is 75-74-1.

What is the molecular formula and weight of Tetramethyllead?

The molecular formula of Tetramethyllead is C4H12Pb and its molar mass is 267.34 g/mol.

What is Tetramethyllead used for?

Antiknock additive for gasolines. Dilute grade used for blending of gasolines used in laboratory engine testing. Antiknock agents in aviation gasoline (Lead alkyl, mixed). The predominant use for tetramethyl lead is as an octane improver, or anti-knock additive ...

Is Tetramethyllead hazardous?

Tetramethyllead carries the GHS signal word "Danger". Main hazards: flammable liquid and vapour, fatal if swallowed. fatal in contact with skin. fatal if inhaled, fatal if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Tetramethyllead?

Tetramethyllead is usually classified under HS code 293110 (Tetramethyl lead and tetraethyl lead). This is indicative, confirm it with your customs broker before shipping.

Can I buy Tetramethyllead on CompoundList?

Tetramethyllead is a controlled substance. Only documented suppliers can list it, and buyers must upload a valid licence with their request. Every request is reviewed by our compliance team before suppliers see it.

Guides for buyers

Practical guides that help when you source, ship or handle Tetramethyllead

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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