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Oncology and immunology drugs

Thiotepa

Also known as THIO-TEPA, Triethylenethiophosphoramide, Thiophosphamide

CAS 52-24-4Formula C6H12N3PSMolar mass 189.22 g/molEC 200-135-7
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Harmful or irritant, Serious health hazard 104 suppliers listed Drug substance
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Thiotepa chemical structure, C6H12N3PS, CAS 52-24-4
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals from pentane or ether
Melting point
51.5 °C
Boiling point
133.3 °C
Solubility
In water, 19 g/100 mL at 25 °C
HS code
293399
Category
Oncology and immunology drugs
UN number
UN 2811
Illustrative photo, drums, an IBC tote and sacks in a chemical warehouse in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Thiotepa?

Plain description, key identifiers and synonyms

Thiotepa is a member of aziridines.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
tris(aziridin-1-yl)-sulfanylidene-λ5-phosphane
CAS number
52-24-4 CAS number cross-checkedOther or deprecated CAS: 1631739-26-8
EC number
200-135-7
Molecular formula
C6H12N3PS
UNII
905Z5W3GKH
MDL number
MFCD00145452
InChIKey
FOCVUCIESVLUNU-UHFFFAOYSA-N
InChI
InChI=1S/C6H12N3PS/c11-10(7-1-2-7,8-3-4-8)9-5-6-9/h1-6H2
SMILES (canonical and isomeric)
C1CN1P(=S)(N2CC2)N3CC3

Synonyms

  • THIO-TEPA
  • Triethylenethiophosphoramide
  • Thiophosphamide
  • Thioplex
  • Tespamin
  • Tespamine
  • Tifosyl
  • Thiofozil
  • Girostan
  • Stepa
  • Oncotiotepa
  • TESPA
  • Thiotef
  • tepadina
  • Ledertepa
  • Tiotepa
  • Tris(1-aziridinyl)phosphine sulfide
  • Thiotriethylenephosphoramide
  • TIO TEF
  • Tepylute
  • Thiophosphamidum
  • Tris(ethylenimino)thiophosphate
  • Triethylene thiophosphoramide
  • N,N',N''-Triethylenethiophosphoramide
  • Triaziridinylphosphine sulfide
Show all 39 synonyms
  • Triethylenethiophosphorotriamide
  • Thiotepum
  • Phosphorothioic acid triethylenetriamide
  • Tri(ethyleneimino)thiophosphoramide
  • Tris(1-aziridinyl)phosphine sulphide
  • N,N',N''-Triethylenethiophosphamide
  • N,N',N''-Triethylenephosphorothioic triamide
  • 1,1',1''-Phosphinothioylidynetrisaziridine
  • N,N',N''-Tri-1,2-ethanediylthiophosphoramide
  • Aziridine,1,1',1''-phosphinothioylidynetris-
  • WR 45312
  • tris(aziridin-1-yl)-lambda5-phosphanethione
  • tris(aziridin-1-yl)-sulfanylidenephosphorane
  • Thio Tepa

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystals from pentane or etherexp.
Odour
Faint odorexp.
Melting point
51.5 °Cexp.
Boiling point
133.3 °Cexp.
Solubility
In water, 19 g/100 mL at 25 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
189.22 g/molcalc.
Exact mass
189.049 Dacalc.
LogP (octanol/water)
0.16calc.
Topological polar surface area
9.03 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
1calc.
Rotatable bonds
3calc.
Heavy atoms
11calc.
Rings
3calc.
Aromatic rings
0calc.
Fraction sp3 carbons
1calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, S=P(N1CC1)(N1CC1)N1CC1

S=P(N1CC1)(N1CC1)N1CC1

3 rings, 11 atoms. This chemical is the scaffold itself.

3 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H300Fatal if swallowed.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
  • H340May cause genetic defects.
  • H350May cause cancer.
  • H360May damage fertility or the unborn child.
Precautionary statements (21)
  • P203Obtain, read and follow all safety instructions before use.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.
UN number
UN 2811

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Thiotepa suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 104 suppliers
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Where suppliers are based

104 suppliers in 18 countries

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Thiotepa price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Veterinary medication:.

Antineoplastic Agents, Alkylating, Myeloablative Agonists.

Insect sterilant.

Pharmacological actions

  • Antineoplastic Agents, Alkylating
  • Myeloablative Agonists

Roles

  • anti-anaemic agent
  • antifibrotic agent
  • antineoplastic agent
  • pharmaceutical

Pharmacology

Thiotepa is an Alkylating Drug. The mechanism of action of thiotepa is as an Alkylating Activity.

How it is made

The preparation of (thiotepa) ... is carried out by the reaction of ethyleneimine (aziridine) with thiophosphoryl chloride in presence of triethylamine in dry benzene as solvent. An improved process used ethylenimine generated in situ from 2-bromoethylamine hydrobromide.

Preparation: Kuh, Seeger, United States of America patent 2670347 (1954 to American Cyanamid).

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: Thiotepa (INN), Ref no: 310, Annex ref: II/310
  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Thiotepa is traded under.

HS 2933.99Indicative HS code

Heterocyclic compounds with nitrogen hetero-atom(s) only, other

World exports in 2024
$12.1B
−31.0% vs 2023, imports $28.8B
2019 to 2024
Top exporters
  1. China30.5%
  2. India * partner reported16.3%
  3. Ireland9.0%
Top importers
  1. Slovenia31.7%
  2. Italy24.2%
  3. United States5.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Thiotepa is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Thiotepa, based on the data on this page

What is Thiotepa?

Thiotepa is a member of aziridines.

What is the CAS number of Thiotepa?

The CAS registry number of Thiotepa is 52-24-4. Other or deprecated CAS numbers: 1631739-26-8.

What is the molecular formula and weight of Thiotepa?

The molecular formula of Thiotepa is C6H12N3PS and its molar mass is 189.22 g/mol.

What is Thiotepa used for?

Veterinary medication:. Antineoplastic Agents, Alkylating, Myeloablative Agonists. Insect sterilant.

Is Thiotepa hazardous?

Thiotepa carries the GHS signal word "Danger". Main hazards: fatal if swallowed, causes skin irritation, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Thiotepa?

Thiotepa is usually classified under HS code 293399 (Heterocyclic compounds with nitrogen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Thiotepa?

CompoundList lists 104 suppliers of Thiotepa in China, United States, India, Germany and 14 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Thiotepa in India?

8 suppliers in India list Thiotepa on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Thiotepa?

Suppliers quote Thiotepa on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Thiotepa

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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