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Oncology and immunology drugs

Thiotepa safety data

GHS hazards, precautions, first aid, handling and transport for Thiotepa. A classification summary, not a safety data sheet.
CAS 52-24-4Formula C6H12N3PS

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

GHS classification

Pictograms, signal word and hazard classes of the GHS classification

GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard
Signal word
Danger

Hazard classes and categories

  • Acute Tox. 1/2 (oral)
  • Skin Irrit. 2
  • Eye Irrit. 2
  • STOT SE 3 (respiratory irritation)
  • Muta. 1A/1B
  • Carc. 1A/1B
  • Repr. 1A/1B

Hazard statements

H codes grouped by type. Percentages show the share of classification notifications that report the statement

Health hazards

  • H300Fatal if swallowed.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
  • H340May cause genetic defects.
  • H350May cause cancer.
  • H360May damage fertility or the unborn child.

Precautionary statements

P codes for prevention, response, storage and disposal

Prevention

  • P203Obtain, read and follow all safety instructions before use.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.

Response

  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.

Storage

  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.

Disposal

  • P501Dispose of contents and container in accordance with local regulations.

First aid

General first aid measures. Get medical advice if you feel unwell

If inhaled
IMMEDIATELY leave the contaminated area, take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used, if not available, use a level of protection greater than or equal to that advised under Protective Clothing.
Skin contact
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.
Eye contact
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.
If swallowed
If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Generally, the induction of vomiting is NOT recommended outside of a physician's care due to the risk of aspirating the chemical into the victim's lungs. However, if the victim is conscious and not convulsing and if medical help is not readily available, consider the risk of inducing vomiting because of the high toxicity of the chemical ingested. Ipecac syrup or salt water may be used in such an emergency. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure th…

Handling, storage and disposal

Summaries only, follow the supplier SDS for your grade

Safe handling

Eye/face protection: Face shield and safety glasses. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection: Handle with gloves.

Storage

Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature 2 - 8 °C. Store in a refrigerator between 2 deg to 8 °C (36 deg to 46 °F). PROTECT FROM LIGHT AT ALL TIMES.

Disposal

SRP: Expired or waste pharmaceuticals shall carefully take into consideration applicable DEA, EPA, and FDA regulations. It is not appropriate to dispose by flushing the pharmaceutical down the toilet or discarding to trash. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator. SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria.

Exposure limits and toxicity

Occupational exposure limits and toxicity data

Thiotepa is known to be a human carcinogen based on sufficient evidence from studies in humans. The major adverse effect of thiotepa is hematologic toxicity, which is usually dose related and cumulative. Adverse hematopoietic effects include leukopenia, anemia, thrombocytopenia, and pancytopenia which is sometimes fatal. Hematologic status must be carefully monitored in patients receiving thiotepa. Although the leukocyte nadir may occur at 10-14 days when thiotepa is given once weekly IV, initial effects on bone marrow may not be evident for up to 30 days.

Transport information

UN dangerous goods classification for road, sea and air

UN number
UN 2811

Shipping rules depend on mode, quantity and packaging. Confirm the classification with the supplier SDS and your freight forwarder.

Supplier safety data sheets

SDS documents uploaded by suppliers who list this chemical

No supplier has uploaded an SDS for Thiotepa yet. Suppliers usually send one with their quote. Request quotes

Safety questions

Quick answers about handling Thiotepa safely

Is Thiotepa hazardous?

Thiotepa carries the GHS signal word "Danger". Main hazards: fatal if swallowed, causes skin irritation, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

Which GHS pictograms apply to Thiotepa?

The GHS classification of Thiotepa shows 3 pictograms: GHS06 (acute toxicity (severe)), GHS07 (harmful or irritant), GHS08 (serious health hazard).

What is the UN number of Thiotepa?

Thiotepa is transported under UN 2811. Check the supplier SDS and the current ADR, IMDG or IATA rules before shipping.

How should Thiotepa be stored?

Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature 2 - 8 °C. Store in a refrigerator between 2 deg to 8 °C (36 deg to 46 °F). PROTECT FROM LIGHT AT ALL TIMES.

Where can I get the SDS for Thiotepa?

Ask the supplier for the safety data sheet of the exact grade you buy. Suppliers on CompoundList can attach their SDS to listings and send it with a quote. This page is a GHS classification summary, not an SDS.

GHS classification summary, not an SDS. Always check the supplier's SDS. Last updated 7 Oct 2026. Report an error

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