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Amino acids and derivatives

(±)-Thyroxine

Also known as DL-Thyroxine, Thyroxine, dl-, (+-)-Thyroxine

CAS 300-30-1Formula C15H11I4NO4Molar mass 776.87 g/molEC 206-088-9
GHS signal word: Danger. Pictograms: Serious health hazard 53 suppliers listed
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(±)-Thyroxine chemical structure, C15H11I4NO4, CAS 300-30-1
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
300-30-1
Formula
C15H11I4NO4
Molar mass
776.87 g/mol
EC number
206-088-9
HS code
293790
Category
Amino acids and derivatives

What is (±)-Thyroxine?

Plain description, key identifiers and synonyms

Thyroxine is an iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions. It has a role as a mitogen. It is an iodophenol, an iodothyronine, a 2-halophenol, a tyrosine derivative and a non-proteinogenic alpha-amino acid. It is a tautomer of a thyroxine zwitterion.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid
CAS number
300-30-1 CAS number cross-checkedOther or deprecated CAS: 51-48-9, 55-03-8, 7488-70-2
EC number
206-088-9
Molecular formula
C15H11I4NO4
UNII
QR0BV3BRIA
MDL number
MFCD00063058
InChIKey
XUIIKFGFIJCVMT-UHFFFAOYSA-N
InChI
InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)
SMILES (canonical and isomeric)
C1=C(C=C(C(=C1I)OC2=CC(=C(C(=C2)I)O)I)I)CC(C(=O)O)N

Synonyms

  • DL-Thyroxine
  • Thyroxine, dl-
  • (+-)-Thyroxine
  • O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-DL-tyrosine
  • 2-amino-3-[4-(4-hydroxy-3,5-diiodo-phenoxy)-3,5-diiodo-phenyl]propanoic acid
  • Levothyroxine, T4
  • Levoroxine
  • Thyroxevan
  • Dathroid
  • Laevoxin
  • Roxstan
  • Sodium thyroxin
  • Ro-thyroxine
  • D-T4, D-Thyroxine
  • Synthroid sodium
  • Sodium l-thyroxin
  • Monosodium thyroxine
  • THX
  • T4 (pharmaceutical)
  • DL-Thyroxine, na
  • L-Thyroxine (Levothyroxine)
  • 3,5,5'-Tetraiodo-L-thyronine
  • US10322118, Entry 6
  • L-Tyrosine,5-diiodophenyl)-3,5-diiodo-
  • dl-O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodotyrosine
Show all 30 synonyms
  • DL-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-
  • L-Tyrosine,5-diiodophenyl)-3,5-diiodo-, monosodium salt
  • (.+/-.)-O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodotyrosine
  • 4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenylalanine #
  • (+/-)-3-(4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)alanine

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
776.87 g/molcalc.
Exact mass
776.6867 Dacalc.
LogP (octanol/water)
4.56calc.
Topological polar surface area
92.78 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
5calc.
Heavy atoms
24calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.13calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(Oc2ccccc2)cc1

c1ccc(Oc2ccccc2)cc1

2 rings, 13 atoms, the Diphenyl ether ring system.

9,579 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H372Causes damage to organs through prolonged or repeated exposure.
Precautionary statements (5)
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P319Get medical help if you feel unwell.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

(±)-Thyroxine suppliers

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All 53 suppliers
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Where suppliers are based

53 suppliers in 11 countries

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(±)-Thyroxine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • mitogen

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code (±)-Thyroxine is traded under.

HS 2937.90Indicative HS code

Derivatives and structural analogues thereof, including chain modified polypeptides, used primarily as…

World exports in 2024
$366M
−8.6% vs 2023, imports $397M
2019 to 2024
Top exporters
  1. France * partner reported31.2%
  2. Ireland21.7%
  3. Germany12.7%
Top importers
  1. United States44.2%
  2. France * partner reported20.3%
  3. China7.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for (±)-Thyroxine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about (±)-Thyroxine, based on the data on this page

What is (±)-Thyroxine?

Thyroxine is an iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions. It has a role as a mitogen. It is an iodophenol, an iodothyronine, a 2-halophenol, a tyrosine derivative and a non-proteinogenic alpha-amino acid. It is a tautomer of a thyroxine zwitterion.

What is the CAS number of (±)-Thyroxine?

The CAS registry number of (±)-Thyroxine is 300-30-1. Other or deprecated CAS numbers: 51-48-9, 55-03-8, 7488-70-2.

What is the molecular formula and weight of (±)-Thyroxine?

The molecular formula of (±)-Thyroxine is C15H11I4NO4 and its molar mass is 776.87 g/mol.

What is (±)-Thyroxine used for?

Known uses and roles of (±)-Thyroxine include mitogen.

Is (±)-Thyroxine hazardous?

(±)-Thyroxine carries the GHS signal word "Danger". Main hazards: causes damage to organs through prolonged or repeated exposure. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of (±)-Thyroxine?

(±)-Thyroxine is usually classified under HS code 293790 (Hormones, prostaglandins, thromboxanes and leukotrienes, natural or reproduced by…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy (±)-Thyroxine?

CompoundList lists 53 suppliers of (±)-Thyroxine in China, United States, United Kingdom, Spain and 7 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of (±)-Thyroxine?

Suppliers quote (±)-Thyroxine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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