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Impurities and reference standards

D-Thyroxine

Also known as Dextrothyroxine, (2R)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-D-tyrosine

CAS 51-49-0Formula C15H11I4NO4Molar mass 776.87 g/molEC 200-102-7
GHS signal word: Warning. Pictograms: Harmful or irritant 5 suppliers listed
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D-Thyroxine chemical structure, C15H11I4NO4, CAS 51-49-0
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
51-49-0
Formula
C15H11I4NO4
Molar mass
776.87 g/mol
EC number
200-102-7
HS code
292250
Category
Impurities and reference standards

What is D-Thyroxine?

Plain description, key identifiers and synonyms

D-thyroxine is the D-enantiomer of thyroxine. It is a thyroxine and a D-tyrosine derivative. It is an enantiomer of a L-thyroxine.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2R)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid
CAS number
51-49-0 CAS number cross-checked
EC number
200-102-7
Molecular formula
C15H11I4NO4
UNII
4W9K63FION
MDL number
MFCD00063056
InChIKey
XUIIKFGFIJCVMT-GFCCVEGCSA-N
InChI
InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m1/s1
Canonical SMILES
NC(Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O
Isomeric SMILES
C1=C(C=C(C(=C1I)OC2=CC(=C(C(=C2)I)O)I)I)C[C@H](C(=O)O)N

Synonyms

  • Dextrothyroxine
  • (2R)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid
  • O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-D-tyrosine
  • D Thyroxine
  • (2R)-2-amino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)propanoic acid
  • (R)-2-Amino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)propanoic acid
  • Choloxin
  • D-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-
  • Biotirmone
  • Dextrothyroxinum
  • (2R)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic aci d
  • (R)-2-Amino-3-(4-(4-hydroxy-35-diiodophenoxy)-35-diiodophenyl)propanoic acid
  • D-T4, D-Thyroxine
  • D-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, Thyroxine, D- (8CI), 3,3',5,5'-Tetraiodo-D-thyronine, D-T4, D-Thyroxine, Dextrothyroxine
  • D-Thyroxine, 99%
  • D-4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodobenzylalanine
  • Levothyroxine Impurity 29
  • (2R)-2-amino-3-[4-(4-hydroxy-3,5-diiodo-phenoxy)-3,5-diiodo-phenyl]propanoic acid
  • (R)-2-Amino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)propanoicacid

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
776.87 g/molcalc.
Exact mass
776.6867 Dacalc.
LogP (octanol/water)
4.56calc.
Topological polar surface area
92.78 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
5calc.
Heavy atoms
24calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.13calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(Oc2ccccc2)cc1

c1ccc(Oc2ccccc2)cc1

2 rings, 13 atoms, the Diphenyl ether ring system.

9,579 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
  • H312Harmful in contact with skin.
  • H332Harmful if inhaled.
Precautionary statements (13)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P317Get medical help.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

D-Thyroxine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 5 suppliers
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Where suppliers are based

5 suppliers in 3 countries

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D-Thyroxine price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Roles

  • cardiovascular drug
  • pharmaceutical

Pharmacology

Dextrothyroxine is the dextrorotary isomer of thyroxine, a thyroid hormone with antihyperlipidemic activity. Dextrothyroxine stimulates the formation of low-density lipoprotein (LDL) and increases the catabolism of LDL thereby leading to increased excretion of cholesterol and bile acids via the biliary route. This results in a reduction in serum cholesterol and LDL.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code D-Thyroxine is traded under.

HS 2922.50Indicative HS code

Amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function

World exports in 2024
$3.29B
−5.9% vs 2023, imports $3.19B
2019 to 2024
Top exporters
  1. China39.2%
  2. United Kingdom27.1%
  3. India * partner reported4.8%
Top importers
  1. United States20.7%
  2. Germany7.6%
  3. Italy6.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for D-Thyroxine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about D-Thyroxine, based on the data on this page

What is D-Thyroxine?

D-thyroxine is the D-enantiomer of thyroxine. It is a thyroxine and a D-tyrosine derivative. It is an enantiomer of a L-thyroxine.

What is the CAS number of D-Thyroxine?

The CAS registry number of D-Thyroxine is 51-49-0.

What is the molecular formula and weight of D-Thyroxine?

The molecular formula of D-Thyroxine is C15H11I4NO4 and its molar mass is 776.87 g/mol.

What is D-Thyroxine used for?

Known uses and roles of D-Thyroxine include cardiovascular drug and pharmaceutical.

Is D-Thyroxine hazardous?

D-Thyroxine carries the GHS signal word "Warning". Main hazards: harmful if swallowed, harmful in contact with skin, harmful if inhaled. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of D-Thyroxine?

D-Thyroxine is usually classified under HS code 292250 (Amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function). This is indicative, confirm it with your customs broker before shipping.

Where can I buy D-Thyroxine?

CompoundList lists 5 suppliers of D-Thyroxine in China, United States and Germany. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of D-Thyroxine?

Suppliers quote D-Thyroxine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle D-Thyroxine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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