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Screening compounds

Tideglusib

Also known as 4-Benzyl-2-(naphthalen-1-yl)-1,2,4-thiadiazolidine-3,5-dione, tideglusibum, Zentylor

CAS 865854-05-3Formula C19H14N2O2SMolar mass 334.40 g/mol
7 suppliers listed
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Tideglusib chemical structure, C19H14N2O2S, CAS 865854-05-3
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
865854-05-3
Formula
C19H14N2O2S
Molar mass
334.40 g/mol
HS code
293499
Category
Screening compounds

What is Tideglusib?

Plain description, key identifiers and synonyms

Tideglusib is a member of the class of thiadiazolidines that is 1,2,4-thiadiazolidine-3,5-dione which is substituted by a naphthalen-1-yl group at position 2 and by a benzyl group at position 4. It is a non-ATP competitive inhibitor of glycogen synthase kinase 3beta (GSK3beta) and has neuroprotective effects. Currently under clinical investigation for the treatment of Alzheimer's disease and progressive supranuclear palsy. It has a role as a neuroprotective agent, an anti-inflammatory agent, an apoptosis inducer and an EC 2.7.11.26 (tau-protein kinase) inhibitor. It is a member of benzenes, a member of naphthalenes and a thiadiazolidine.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-benzyl-2-naphthalen-1-yl-1,2,4-thiadiazolidine-3,5-dione
CAS number
865854-05-3 CAS number cross-checkedOther or deprecated CAS: 1353564-66-5
Molecular formula
C19H14N2O2S
UNII
Q747Y6TT42
MDL number
MFCD18633296
InChIKey
PMJIHLSCWIDGMD-UHFFFAOYSA-N
InChI
InChI=1S/C19H14N2O2S/c22-18-20(13-14-7-2-1-3-8-14)19(23)24-21(18)17-12-6-10-15-9-4-5-11-16(15)17/h1-12H,13H2
SMILES (canonical and isomeric)
C1=CC=C(C=C1)CN2C(=O)N(SC2=O)C3=CC=CC4=CC=CC=C43

Synonyms

  • 4-Benzyl-2-(naphthalen-1-yl)-1,2,4-thiadiazolidine-3,5-dione
  • tideglusibum
  • Zentylor
  • Nypta
  • Zentylor nypta
  • 4-benzyl-2-(a-naphtyl)-1,2,4-thiadiazolidine-3,5-dione
  • NP12 compound
  • NP-12 compound
  • 4-benzyl-2-(naphthalene-1-yl)-1,2,4-thiadiazolidine-3,5-dione
  • NP 031112
  • Tideglusib(NP-031112)
  • Tideglusib, >=98% (HPLC)
  • 4-Benzyl-2-(naphthalen-1-yl)-[1,2,4]thiadiazolidine-3,5-dione
  • 2-(1-naphthalenyl)-4-(phenylmethyl)-1,2,4-thiadiazolidine-3,5-dione
  • 4-benzyl-2-(1-naphthyl)-1,2,4-thiadiazolidine-3,5-dione
  • 4-benzyl-2-(naphthalen-1-yl)-(1,2,4)thiadiazolidine-3,5-dione
  • 4-benzyl-2-naphthalen-1-yl-1,2,4-thiadiazolidine-3,5-dione
  • 1,2,4-Thiadiazolidine-3,5-dione, 2-(1-naphthalenyl)-4-(phenylmethyl)-
  • Tideglusib(NP-031112)?
  • 4-Benzyl-2-(a-
  • Tideglusib (np031112)
  • Tideglusib,CAS:865854-05-3
  • Sdccgsbi-0654483.p001
  • Tideglusib (NP031112, NP-12)
  • Tideglusib (NP-031112, NP-12)
Show all 26 synonyms
  • 4-Benzyl-2-(a-naphthyl)-1,2,4-thiadiazolidine-3,5-dione

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
334.40 g/molcalc.
Exact mass
334.0776 Dacalc.
LogP (octanol/water)
3.26calc.
Topological polar surface area
44 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
3calc.
Heavy atoms
24calc.
Rings
4calc.
Aromatic rings
4calc.
Fraction sp3 carbons
0.05calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1sn(-c2cccc3ccccc23)c(=O)n1Cc1ccccc1

O=c1sn(-c2cccc3ccccc23)c(=O)n1Cc1ccccc1

4 rings, 24 atoms. This chemical is the scaffold itself.

1 other chemical share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Tideglusib suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 7 suppliers
7 of 7 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

7 suppliers in 3 countries

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Tideglusib price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • anti-inflammatory agent
  • apoptosis inducer
  • enzyme inhibitor
  • neuroprotective agent
  • pharmaceutical
  • protective agent
  • protein kinase inhibitor

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Tideglusib is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Tideglusib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Tideglusib, based on the data on this page

What is Tideglusib?

Tideglusib is a member of the class of thiadiazolidines that is 1,2,4-thiadiazolidine-3,5-dione which is substituted by a naphthalen-1-yl group at position 2 and by a benzyl group at position 4. It is a non-ATP competitive inhibitor of glycogen synthase kinase 3beta (GSK3beta) and has neuroprotective effects.

What is the CAS number of Tideglusib?

The CAS registry number of Tideglusib is 865854-05-3. Other or deprecated CAS numbers: 1353564-66-5.

What is the molecular formula and weight of Tideglusib?

The molecular formula of Tideglusib is C19H14N2O2S and its molar mass is 334.40 g/mol.

What is Tideglusib used for?

Known uses and roles of Tideglusib include building blocks in research and laboratory, screening compounds in research and laboratory, anti-inflammatory agent, apoptosis inducer, enzyme inhibitor and 4 more.

Is Tideglusib hazardous?

No GHS hazard classification for Tideglusib is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Tideglusib?

Tideglusib is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Tideglusib?

CompoundList lists 7 suppliers of Tideglusib in China, Canada and United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Tideglusib?

Suppliers quote Tideglusib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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