Timolol (CAS 26839-75-8): properties, price, suppliers and safety

What is Timolol?

Plain description, key identifiers and synonyms

(S)-timolol (anhydrous) is the (S)-() (more active) enantiomer of timolol. A beta-adrenergic antagonist, both the hemihydrate and the maleate salt are used in the mangement of glaucoma, hypertension, angina pectoris and myocardial infarction, and for the prevention of migraine. It has a role as a beta-adrenergic antagonist, an antihypertensive agent, an anti-arrhythmia drug and an antiglaucoma drug. It is a conjugate base of a (S)-timolol(1+). It is an enantiomer of a (R)-timolol.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name: (2S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol
CAS number: 26839-75-8 CAS number cross-checked
EC number: 248-032-6
Molecular formula: C₁₃H₂₄N₄O₃S
UNII: 5JKY92S7BR
InChIKey: BLJRIMJGRPQVNF-JTQLQIEISA-N
InChI: InChI=1S/C13H24N4O3S/c1-13(2,3)14-8-10(18)9-20-12-11(15-21-16-12)17-4-6-19-7-5-17/h10,14,18H,4-9H2,1-3H3/t10-/m0/s1
Canonical SMILES: CC(C)(C)NCC(O)COc1nsnc1N1CCOCC1
Isomeric SMILES: CC(C)(C)NC[C@@H](COC1=NSN=C1N2CCOCC2)O

Synonyms

Betimol
Timololum
Timolol anhydrous
(-)-3-Morpholino-4-(3-tert-butylamino-2-hydroxypropoxy)-1,2,5-thiadiazole
S-(-)-3-(3-tert-Butylamino-2-hydroxypropoxy)-4-morpholino-1,2,5-thiadiazole
(S)-1-(1,1-(Dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-2-propanol
(S)-1-(tert-Butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)propan-2-ol
Betim
Timololo
Nyogel
Tiopex
Glau-opt
2-Propanol, 1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-, hemihydrate, (S)-
1-(tert-butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)propan-2-ol
(S)-timolol
(2S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol
Timolol (INN)
Betimol (TN)
Timopic
(S)-timolol (anhydrous)
(2S)-1-(tert-butylamino)-3-{[4-(morpholin-4-yl)-1,2,5-thiadiazol-3-yl]oxy}propan-2-ol
(2S)-1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-2-propanol
2-Propanol, 1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-, (2S)-
(2S)-3-[(tert-butyl)amino]-1-(4-morpholin-4-yl(1,2,5-thiadiazol-3-yl)oxy)propa n-2-ol
2-Propanol, 1-[(1,1-dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-, (2S)-

Show all 29 synonyms

(S)-Timolol, Arutimol, L-Timolol
Tocris-0649
(2S)-1-[(1,1-dimethylethyl)amino]-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol
2-Propanol, 1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-, (S)-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Melting point	71.5 to 72.5exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight	316.43 g/molcalc.
Exact mass	316.1569 Dacalc.
LogP (octanol/water)	0.5calc.
Topological polar surface area	79.74 Å²calc.
Hydrogen bond donors	2calc.
Hydrogen bond acceptors	8calc.
Rotatable bonds	6calc.
Heavy atoms	21calc.
Rings	2calc.
Aromatic rings	1calc.
Fraction sp3 carbons	0.85calc.
Formal charge	0calc.
Stereocentres	1calc.
Lipinski rule of five	Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

c1nsnc1N1CCOCC1

2 rings, 11 atoms, the 4-(1,2,5-Thiadiazol-3-yl)morpholine ring system.

48 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word

Danger

Harmful or irritant

Serious health hazard

Hazard statements

H302Harmful if swallowed.
H351Suspected of causing cancer.
H360May damage fertility or the unborn child.
H361Suspected of damaging fertility or the unborn child.
H362May cause harm to breast-fed children.

Precautionary statements (11)

P203Obtain, read and follow all safety instructions before use.
P260Do not breathe dust, fume, gas, mist, vapours or spray.
P263Avoid contact during pregnancy and while nursing.
P264Wash skin thoroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves, protective clothing, eye protection and face protection.
P301 + P317If swallowed: Get medical help.
P318If exposed or concerned, get medical advice.
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Timolol suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 32 suppliers

Verified only30 of 30 offers

P.R. Pharma Source Pvt. Ltd.
India, MumbaiUnclaimed profile
TimololGrade, purity and minimum order on request
Price on request
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Excella GmbH & Co. KG
Germany, Feucht ManufacturerUnclaimed profile
TimololGrade, purity and minimum order on request
Price on request
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PCAS Finland Oy
Finland, Turku ManufacturerUnclaimed profile
TimololGrade, purity and minimum order on request
Price on request
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Somerset Pharma LLC
ManufacturerUnclaimed profile
BetimolGrade, purity and minimum order on request
Price on request
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001Chemical
China, HangzhouUnclaimed profile
TimololGrade, purity and minimum order on request
Price on request
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10X Chem
United States, San DiegoUnclaimed profile
TimololGrade, purity and minimum order on request
Price on request
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3WAY Pharm Inc
China, ShanghaiUnclaimed profile
TimololGrade, purity and minimum order on request
Price on request
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A2B Chem LLC
United States, San DiegoUnclaimed profile
TimololGrade, purity and minimum order on request
Price on request
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Aa Blocks LLC
United States, San DiegoUnclaimed profile
TimololGrade, purity and minimum order on request
Price on request
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AbaChemScene, LLC
United States, Monmouth JunctionUnclaimed profile
TimololGrade, purity and minimum order on request
Price on request
View

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

32 suppliers in 13 countries

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Timolol price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Use classes: Pharmaceuticals.

Industries and functions

Pharmacological actions

Adrenergic beta-Antagonists
Anti-Arrhythmia Agents
Antihypertensive Agents

Roles

adrenergic agent
adrenergic antagonist
anti-arrhythmia drug
antiglaucoma drug
antihypertensive agent
beta-adrenergic antagonist
beta-adrenergic drug
cardiovascular drug
neurotransmitter agent
ophthalmology drug
pharmaceutical

Pharmacology

Timolol anhydrous is a beta-Adrenergic Blocker. The mechanism of action of timolol anhydrous is as an Adrenergic beta-Antagonist.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

Active ingredient in FDA approved drug labels

United States

TSCA inventory (USA)
Status: Inactive in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Timolol is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024

$26.7B

+15.0% vs 2023, imports $26.3B

2019 to 2024

Top exporters

Ireland26.3%
China15.7%
Singapore10.3%

Top importers

Reported customs values in USD, not prices.Full trade data

The HS code shown for Timolol is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Parent and salt forms, stereoisomers, similar structures and isomers

Salt and hydrate forms

Records that share this compound as their parent

Timolol maleate chemical structure, C17H28N4O7S, CAS 26921-17-5

Timolol maleate26921-17-5C₁₇H₂₈N₄O₇S104 suppliers

Timolol hemihydrate chemical structure, C26H50N8O7S2, CAS 91524-16-2

Timolol hemihydrate91524-16-2C₂₆H₅₀N₈O₇S₂10 suppliers

2-Propanol, 1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-, hydrochloride, (S)- chemical structure, C13H25ClN4O3S, CAS 69267-58-9

2-Propanol, 1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-, hydrochloride, (S)-69267-58-9C₁₃H₂₅ClN₄O₃S

(2R)-1-(tert-Butylamino)-3-{[4-(morpholin-4-yl)-1,2,5-thiadiazol-3-yl]oxy}propan-2-ol, but-2-enedioic acid chemical structure, C17H28N4O7S, CAS 1214981-81-3

(2R)-1-(tert-Butylamino)-3-{[4-(morpholin-4-yl)-1,2,5-thiadiazol-3-yl]oxy}propan-2-ol, but-2-enedioic acid1214981-81-3C₁₇H₂₈N₄O₇S

Orb2565159 chemical structure, C30H52N8O10S2, CAS 33305-95-2

Orb256515933305-95-2C₃₀H₅₂N₈O₁₀S₂

But-2-enedioic acid--1-(tert-butylamino)-3-{[4-(morpholin-4-yl)-1,2,5-thiadiazol-3-yl]oxy}propan-2-ol (1/2) chemical structure, C30H52N8O10S2

But-2-enedioic acid--1-(tert-butylamino)-3-{[4-(morpholin-4-yl)-1,2,5-thiadiazol-3-yl]oxy}propan-2-ol (1/2)C₃₀H₅₂N₈O₁₀S₂

Stereoisomers and isotopic forms

Same connectivity, different stereochemistry or isotopes (same InChIKey skeleton)

(R)-Timolol chemical structure, C13H24N4O3S, CAS 26839-76-9

(R)-Timolol26839-76-9C₁₃H₂₄N₄O₃S

(±)-Timolol chemical structure, C13H24N4O3S, CAS 29023-48-1

(±)-Timolol29023-48-1C₁₃H₂₄N₄O₃S

Similar structures

Nearest neighbours by Morgan fingerprint Tanimoto similarity

3-(3-(tert-Butylamino)-2-hydroxypropoxy)-4-morpholino-1,2,5-thiadiazole monomaleate chemical structure, C17H28N4O7S, CAS 57073-55-9

Timolol maleate, (R)- chemical structure, C17H28N4O7S, CAS 26839-77-0

Isotimolol chemical structure, C13H24N4O3S, CAS 59697-06-2

(S)-2-(Tert.-butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)-1-propanol chemical structure, C13H24N4O3S, CAS 158636-96-5

Timolol maleate ester chemical structure, C17H26N4O6S, CAS 1026075-53-5

Brimonidine Tartrate, timolol maleate chemical structure, C24H34BrN9O3S, CAS 952743-07-6

Same formula isomers

Different compounds that share this molecular formula

All isomers

Bupirimate chemical structure, C13H24N4O3S, CAS 41483-43-6

Bupirimate41483-43-6C₁₃H₂₄N₄O₃S6 suppliers

Isotimolol59697-06-2C₁₃H₂₄N₄O₃S1 supplier

(S)-2-(Tert.-butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)-1-propanol158636-96-5C₁₃H₂₄N₄O₃S

2-((2RS)-3-((1,1-Dimethylethyl)amino)-2-hydroxypropyl)-4-(morpholin-4-yl)-1,2,5-thiadiazol-3(2H)-one chemical structure, C13H24N4O3S, CAS 158636-97-6

2-((2RS)-3-((1,1-Dimethylethyl)amino)-2-hydroxypropyl)-4-(morpholin-4-yl)-1,2,5-thiadiazol-3(2H)-one158636-97-6C₁₃H₂₄N₄O₃S

N-(1-Cyano-1,2-dimethylpropyl)-2-(4-methanesulfonylpiperazin-1-yl)acetamide chemical structure, C13H24N4O3S, CAS 1197643-76-7

N-(1-Cyano-1,2-dimethylpropyl)-2-(4-methanesulfonylpiperazin-1-yl)acetamide1197643-76-7C₁₃H₂₄N₄O₃S

N-(1-Cyano-1-methylethyl)-2-[4-(ethanesulfonyl)piperazin-1-yl]-N-methylacetamide chemical structure, C13H24N4O3S, CAS 1258745-24-2

N-(1-Cyano-1-methylethyl)-2-[4-(ethanesulfonyl)piperazin-1-yl]-N-methylacetamide1258745-24-2C₁₃H₂₄N₄O₃S

1,1-Ethanediamine, N-[2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N'-methyl-2-nitro- chemical structure, C13H24N4O3S, CAS 86092-70-8

1,1-Ethanediamine, N-[2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N'-methyl-2-nitro-86092-70-8C₁₃H₂₄N₄O₃S

tert-Butyl N-{2-amino-2-[2-(dimethylamino)-4-methoxy-1,3-thiazol-5-yl]ethyl}carbamate chemical structure, C13H24N4O3S, CAS 2229224-48-8

tert-Butyl N-{2-amino-2-[2-(dimethylamino)-4-methoxy-1,3-thiazol-5-yl]ethyl}carbamate2229224-48-8C₁₃H₂₄N₄O₃S

tert-Butyl N-{2-amino-1-[2-(dimethylamino)-4-methoxy-1,3-thiazol-5-yl]ethyl}carbamate chemical structure, C13H24N4O3S, CAS 2229195-93-9

tert-Butyl N-{2-amino-1-[2-(dimethylamino)-4-methoxy-1,3-thiazol-5-yl]ethyl}carbamate2229195-93-9C₁₃H₂₄N₄O₃S

Frequently asked questions

Quick answers about Timolol, based on the data on this page

What is Timolol?

(S)-timolol (anhydrous) is the (S)-() (more active) enantiomer of timolol. A beta-adrenergic antagonist, both the hemihydrate and the maleate salt are used in the mangement of glaucoma, hypertension, angina pectoris and myocardial infarction, and for the prevention of migraine.

What is the CAS number of Timolol?

The CAS registry number of Timolol is 26839-75-8.

What is the molecular formula and weight of Timolol?

The molecular formula of Timolol is C13H24N4O3S and its molar mass is 316.43 g/mol.

What is Timolol used for?

Use classes: Pharmaceuticals.

Is Timolol hazardous?

Timolol carries the GHS signal word "Danger". Main hazards: harmful if swallowed, suspected of causing cancer, may damage fertility or the unborn child. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Timolol?

Timolol is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Timolol?

CompoundList lists 32 suppliers of Timolol in United States, China, Germany, Ukraine and 9 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Timolol in India?

1 supplier in India list Timolol on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Timolol?

Suppliers quote Timolol on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Timolol

Timolol

Key facts

What is Timolol?

Identifiers

Synonyms

Physical and chemical properties

Physical and chemical properties

Computed descriptors

Murcko scaffold

Safety and hazards

Hazard statements

Timolol suppliers

Where suppliers are based

Send one request to many suppliers

Timolol price

Uses and applications

Industries and functions

Pharmacological actions

Roles

Pharmacology

Regulatory status

Health and food

United States

HS code and trade data

Global trade

Frequently asked questions

What is Timolol?

What is the CAS number of Timolol?

What is the molecular formula and weight of Timolol?

What is Timolol used for?

Is Timolol hazardous?

What is the HS code of Timolol?

Where can I buy Timolol?

Where can I buy Timolol in India?

What is the price of Timolol?

Guides for buyers

Get quotes for Timolol

Key facts

What is Timolol?

Identifiers

Synonyms

Physical and chemical properties

Physical and chemical properties

Computed descriptors

Murcko scaffold

Safety and hazards

Hazard statements

Timolol suppliers

Where suppliers are based

Send one request to many suppliers

Timolol price

Uses and applications

Industries and functions

Pharmacological actions

Roles

Pharmacology

Regulatory status

Health and food

United States

HS code and trade data

Global trade

Related chemicals

Salt and hydrate forms

Stereoisomers and isotopic forms

Similar structures

Same formula isomers

Frequently asked questions

What is Timolol?

What is the CAS number of Timolol?

What is the molecular formula and weight of Timolol?

What is Timolol used for?

Is Timolol hazardous?

What is the HS code of Timolol?

Where can I buy Timolol?

Where can I buy Timolol in India?

What is the price of Timolol?

Guides for buyers

Get quotes for Timolol