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Antibiotics and anti-infectives

Tobramycin

Also known as Nebramycin VI, Nebramycin 6, Nebramycin factor 6

CAS 32986-56-4Formula C18H37N5O9Molar mass 467.52 g/molEC 251-322-5
GHS signal word: Danger. Pictograms: Harmful or irritant, Serious health hazard, Hazardous to the environment 91 suppliers listed Drug substance
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Tobramycin chemical structure, C18H37N5O9, CAS 32986-56-4
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
32986-56-4
Formula
C18H37N5O9
Appearance
White to off-white powder
Solubility
Freely soluble in water (1 in 1.5 parts)
HS code
294190
Category
Antibiotics and anti-infectives
Illustrative photo, 25 kg white woven sacks of powder on a pallet in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Tobramycin?

Plain description, key identifiers and synonyms

Tobramycin is a amino cyclitol glycoside that is kanamycin B lacking the 3-hydroxy substituent from the 2,6-diaminoglucose ring. It has a role as a toxin, an antimicrobial agent and an antibacterial agent. It is functionally related to a kanamycin B. It is a conjugate base of a tobramycin(5+).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2S,3R,4S,5S,6R)-4-amino-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2R,3R,5S,6R)-3-amino-6-(aminomethyl)-5-hydroxyoxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-6-(hydroxymethyl)oxane-3,5-diol
CAS number
32986-56-4 CAS number cross-checkedOther or deprecated CAS: 79645-27-5
EC numbers
251-322-5, 616-717-2
Molecular formula
C18H37N5O9
UNII
VZ8RRZ51VK
MDL number
MFCD00077885
InChIKey
NLVFBUXFDBBNBW-PBSUHMDJSA-N
InChI
InChI=1S/C18H37N5O9/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18/h5-18,24-28H,1-4,19-23H2/t5-,6+,7+,8-,9+,10+,11-,12+,13+,14-,15+,16-,17+,18+/m0/s1
Canonical SMILES
NCC1OC(OC2C(N)CC(N)C(OC3OC(CO)C(O)C(N)C3O)C2O)C(N)CC1O
Isomeric SMILES
C1[C@@H]([C@H]([C@@H]([C@H]([C@@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)N)O)O)O[C@@H]3[C@@H](C[C@@H]([C@H](O3)CN)O)N)N

Synonyms

  • Nebramycin VI
  • Nebramycin 6
  • Nebramycin factor 6
  • Deoxykanamycin B
  • Tobrex
  • Tobi
  • 3'-Deoxykanamycin B
  • Aktob
  • Tobralex
  • Tobramicina
  • Tobi Podhaler
  • vantobra
  • Tobramycine
  • Obramycin
  • 1-Epitobramycin
  • Tobramycetin
  • Tobramycinum
  • Bethkis
  • Nebicin
  • Kitabis Pak
  • Tobramitsetin
  • Tenebrimycin
  • Tenemycin
  • 4-(2,6-Diamino-2,3,6-trideoxy-alpha-D-glycopyranosyl)-6-(3-amino-3-deoxy-alpha-D-glycopyranosyl)-2-deoxystreptamine
  • D-Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1-6)-O-(2,6-diamino-2,3,6-trideoxy-alpha-D-ribo-hexopyranosyl-(1-4))-2-deoxy-
Show all 38 synonyms
  • O-3-Amino-3-deoxy-alpha-D-glucopyranosyl-(1-6)-O-(2,6-diamino-2,3,6-trideoxy-alpha-D-ribohexopyranosyl-(1-4))-2-deoxy-D-streptamine
  • Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(2,6-diamino-2,3,6-tyrideoxy-alpha-D-ribohexopyranosyl-(1-6))-2-deoxy-, D-
  • O-3-Amino-3-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(2,6-diamino-2,3,6-trideoxy-alpha-D-ribohexopyranosyl-(1-4))-2-deoxy-D-streptamine
  • Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(2,6-diamino-2,3,6-trideoxy-alpha-D-ribohexopyranosyl-(1-6))-2-deoxy-, D-
  • Bramitob
  • Tobravisc
  • Tymbrineb
  • Nebris
  • Tobramycin solution
  • O-3-Amino-3-deoxy-alpha-D-glucopyranosyl-(1-6)-O-[2,6-diamino-2,3,6-trideoxy-alpha-D-ribohexopyranosyl-(1-4)]-2-deoxy-D-streptamine
  • Tobramycin Inhalation
  • Tobramycin Inhalation Solution
  • Tobramycin Ophthalmic Solution

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
White to off-white powderexp.
Solubility
Freely soluble in water (1 in 1.5 parts)exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
467.52 g/molcalc.
Exact mass
467.2591 Dacalc.
LogP (octanol/water)
-6.3calc.
Topological polar surface area
268.2 Ųcalc.
Hydrogen bond donors
10calc.
Hydrogen bond acceptors
14calc.
Rotatable bonds
6calc.
Heavy atoms
32calc.
Rings
3calc.
Aromatic rings
0calc.
Fraction sp3 carbons
1calc.
Formal charge
0calc.
Stereocentres
14calc.
Lipinski rule of five
Fails (2 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1CCC(OC2CCCC(OC3CCCCO3)C2)OC1

C1CCC(OC2CCCC(OC3CCCCO3)C2)OC1

3 rings, 20 atoms.

211 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H315Causes skin irritation.
  • H317May cause an allergic skin reaction.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
  • H360May damage fertility or the unborn child.
  • H361Suspected of damaging fertility or the unborn child.
  • H372Causes damage to organs through prolonged or repeated exposure.
  • H400Very toxic to aquatic life.
  • H411Toxic to aquatic life with long lasting effects.
Precautionary statements (24)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P272Contaminated work clothing should not be allowed out of the workplace.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P333 + P317If skin irritation or rash occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P391Collect spillage.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Tobramycin suppliers

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All 91 suppliers
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Where suppliers are based

91 suppliers in 18 countries

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Tobramycin price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Veterinary medication:.

Anti-Bacterial Agents.

Pharmacological actions

  • Anti-Bacterial Agents

Roles

  • anti-inflammatory agent
  • antibacterial agent
  • antiinfective agent
  • antimicrobial agent
  • metabolite
  • ophthalmology drug
  • pharmaceutical
  • poison
  • toxin

Pharmacology

Tobramycin is an Aminoglycoside Antibacterial.

How it is made

An antibiotic entity separated from an antibiotic complex produced by Streptomyces tenebrarius.

Aminoglycoside antibiotic, component of the nebramycin complex produced by Streptomyces tenebrarius.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Tobramycin is traded under.

HS 2941.90Indicative HS code

Antibiotics, other

World exports in 2024
$6.39B
+2.3% vs 2023, imports $6.97B
2019 to 2024
Top exporters
  1. China39.7%
  2. United States11.3%
  3. Switzerland * partner reported10.9%
Top importers
  1. Italy15.0%
  2. India * partner reported12.0%
  3. China8.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Tobramycin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Tobramycin, based on the data on this page

What is Tobramycin?

Tobramycin is a amino cyclitol glycoside that is kanamycin B lacking the 3-hydroxy substituent from the 2,6-diaminoglucose ring. It has a role as a toxin, an antimicrobial agent and an antibacterial agent. It is functionally related to a kanamycin B. It is a conjugate base of a tobramycin(5+).

What is the CAS number of Tobramycin?

The CAS registry number of Tobramycin is 32986-56-4. Other or deprecated CAS numbers: 79645-27-5.

What is the molecular formula and weight of Tobramycin?

The molecular formula of Tobramycin is C18H37N5O9 and its molar mass is 467.52 g/mol.

What is Tobramycin used for?

Veterinary medication:. Anti-Bacterial Agents.

Is Tobramycin hazardous?

Tobramycin carries the GHS signal word "Danger". Main hazards: causes skin irritation, may cause an allergic skin reaction, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Tobramycin?

Tobramycin is usually classified under HS code 294190 (Antibiotics, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Tobramycin?

CompoundList lists 91 suppliers of Tobramycin in United States, China, United Kingdom, Spain and 14 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Tobramycin in India?

4 suppliers in India list Tobramycin on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Tobramycin?

Suppliers quote Tobramycin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Tobramycin

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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