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Tolvaptan

Also known as jinarc, Jynarque, 7-Chloro-5-hydroxy-1-(2-methyl-4-(2-methylbenzoylamino)benzoyl)2,3,4,5-tetrahydro-1H-1-benzazepine

CAS 150683-30-0Formula C26H25ClN2O3Molar mass 448.95 g/molEC 691-537-5
GHS signal word: Warning. Pictograms: Serious health hazard 101 suppliers listed Drug substance
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Tolvaptan chemical structure, C26H25ClN2O3, CAS 150683-30-0
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
150683-30-0
Formula
C26H25ClN2O3
Appearance
Colorless prisms
Melting point
225.9 °C
HS code
293399
Category
Pharmaceuticals and APIs
Illustrative photo, colourless crystals beside an amber glass bottle on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Tolvaptan?

Plain description, key identifiers and synonyms

Tolvaptan is a racemate comprising of equimolar amounts of (R)- and (S)-tolvaptan. It is a selective vasopressin V2 receptor antagonist used to treat euvolemic and hypervolemic hyponatremia. It is also used in the treatment of rapidly progressing autosomal dominant polycystic kidney disease to slow the rate of cyst development and renal insufficiency. It has a role as an aquaretic and a vasopressin receptor antagonist. It contains a (S)-tolvaptan and a (R)-tolvaptan.

Tolvaptan is a selective, competitive vasopressin receptor 2 antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-[4-(7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide
CAS number
150683-30-0 CAS number cross-checked
EC number
691-537-5
Molecular formula
C26H25ClN2O3
UNII
21G72T1950
MDL number
MFCD09838782
InChIKey
GYHCTFXIZSNGJT-UHFFFAOYSA-N
InChI
InChI=1S/C26H25ClN2O3/c1-16-6-3-4-7-20(16)25(31)28-19-10-11-21(17(2)14-19)26(32)29-13-5-8-24(30)22-15-18(27)9-12-23(22)29/h3-4,6-7,9-12,14-15,24,30H,5,8,13H2,1-2H3,(H,28,31)
SMILES (canonical and isomeric)
CC1=CC=CC=C1C(=O)NC2=CC(=C(C=C2)C(=O)N3CCCC(C4=C3C=CC(=C4)Cl)O)C

Synonyms

  • jinarc
  • Jynarque
  • 7-Chloro-5-hydroxy-1-(2-methyl-4-(2-methylbenzoylamino)benzoyl)2,3,4,5-tetrahydro-1H-1-benzazepine
  • Benzamide, N-(4-((7-chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl)-3-methylphenyl)-2-methyl-
  • tolvaptanum
  • Benzamide, N-[4-[(7-chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methyl-
  • N-(4-(7-chloro-5-hydroxy2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide
  • N-[4-(7-chloro-5-hydroxy2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide
  • N-(4-(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide
  • N-[4-(7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide
  • OPC 41061
  • (R)-(+)-Tolvaptan
  • C26H25ClN2O3
  • N-[4-[(7-Chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methylbenzamide
  • N-[4-(7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide
  • (S)-(-)-Tolvaptan
  • benzazepine derivative, 32
  • Tolvaptan?
  • Tolvaptan (Standard)
  • Tolvaptan (OPC-41061)
  • Tolvaptan - Bio-X trade mark
  • Opc-41061(tolvaptan)
  • PDSP1_001738
  • PDSP2_001721
  • Tolvaptan, >=98% (HPLC), powder
Show all 26 synonyms
  • N-[4-(7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl)-3-methyl-phenyl]-2-methyl-benzamide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Colorless prismsexp.
Melting point
225.9 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
448.95 g/molcalc.
Exact mass
448.1554 Dacalc.
LogP (octanol/water)
5.68calc.
Topological polar surface area
69.64 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
3calc.
Heavy atoms
32calc.
Rings
4calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.23calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(Nc1ccc(C(=O)N2CCCCc3ccccc32)cc1)c1ccccc1

O=C(Nc1ccc(C(=O)N2CCCCc3ccccc32)cc1)c1ccccc1

4 rings, 28 atoms.

30 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H361Suspected of damaging fertility or the unborn child.
  • H362May cause harm to breast-fed children.
Precautionary statements (9)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P263Avoid contact during pregnancy and while nursing.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P318If exposed or concerned, get medical advice.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Tolvaptan suppliers

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All 101 suppliers
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Where suppliers are based

101 suppliers in 17 countries

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Tolvaptan price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Vasopressin V2 Receptor Antagonist.

Pharmacological actions

  • Antidiuretic Hormone Receptor Antagonists

Roles

  • antagonist
  • antineoplastic agent
  • aquaretic
  • cardiovascular drug
  • diuretic
  • hepatoprotective agent
  • hormone antagonist
  • hormone receptor modulator
  • pharmaceutical
  • protective agent
  • receptor modulator
  • renoprotective agent
  • vasopressin receptor antagonist

Pharmacology

Tolvaptan is a Vasopressin V2 Receptor Antagonist. The mechanism of action of tolvaptan is as a Vasopressin V2 Receptor Antagonist.

How it is made

Preparation: H. Ogawa et al., World Intellectual Property Organization patent 9105549, eidem, United States of America patent 5258510 (1991, 1993 both to Otsuka).

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Tolvaptan is traded under.

HS 2933.99Indicative HS code

Heterocyclic compounds with nitrogen hetero-atom(s) only, other

World exports in 2024
$12.1B
−31.0% vs 2023, imports $28.8B
2019 to 2024
Top exporters
  1. China30.5%
  2. India * partner reported16.3%
  3. Ireland9.0%
Top importers
  1. Slovenia31.7%
  2. Italy24.2%
  3. United States5.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Tolvaptan is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Tolvaptan, based on the data on this page

What is Tolvaptan?

Tolvaptan is a racemate comprising of equimolar amounts of (R)- and (S)-tolvaptan. It is a selective vasopressin V2 receptor antagonist used to treat euvolemic and hypervolemic hyponatremia.

What is the CAS number of Tolvaptan?

The CAS registry number of Tolvaptan is 150683-30-0.

What is the molecular formula and weight of Tolvaptan?

The molecular formula of Tolvaptan is C26H25ClN2O3 and its molar mass is 448.95 g/mol.

What is Tolvaptan used for?

Vasopressin V2 Receptor Antagonist.

Is Tolvaptan hazardous?

Tolvaptan carries the GHS signal word "Warning". Main hazards: suspected of damaging fertility or the unborn child, may cause harm to breast-fed children. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Tolvaptan?

Tolvaptan is usually classified under HS code 293399 (Heterocyclic compounds with nitrogen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Tolvaptan?

CompoundList lists 101 suppliers of Tolvaptan in China, United States, India, Germany and 13 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Tolvaptan in India?

17 suppliers in India list Tolvaptan on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Tolvaptan?

Suppliers quote Tolvaptan on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Tolvaptan

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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