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Cardiovascular and metabolic drugs

Tranilast

Also known as Rizaben, Tranilastum, N-(3,4-Dimethoxycinnamoyl)anthranilic acid

CAS 53902-12-8Formula C18H17NO5Molar mass 327.34 g/molEC 621-256-5
GHS signal word: Warning. Pictograms: Harmful or irritant 41 suppliers listed
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Tranilast chemical structure, C18H17NO5, CAS 53902-12-8
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
53902-12-8
Formula
C18H17NO5
Molar mass
327.34 g/mol
EC number
621-256-5
HS code
292429
Category
Cardiovascular and metabolic drugs

What is Tranilast?

Plain description, key identifiers and synonyms

Tranilast is an amidobenzoic acid that is anthranilic acid in which one of the anilino hydrogens is replaced by a 3,4-dimethoxycinnamoyl group. It has a role as an antineoplastic agent, a calcium channel blocker, an anti-asthmatic drug, an anti-allergic agent, a hepatoprotective agent, an aryl hydrocarbon receptor agonist and a nephroprotective agent. It is a secondary carboxamide, a member of cinnamamides, an amidobenzoic acid and a dimethoxybenzene. It is functionally related to an anthranilic acid.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-[[(E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino]benzoic acid
CAS number
53902-12-8 CAS number cross-checkedOther or deprecated CAS: 53902-17-3, 70806-55-2
EC number
621-256-5
Molecular formula
C18H17NO5
UNII
HVF50SMY6E
MDL number
MFCD00864787
InChIKey
NZHGWWWHIYHZNX-CSKARUKUSA-N
InChI
InChI=1S/C18H17NO5/c1-23-15-9-7-12(11-16(15)24-2)8-10-17(20)19-14-6-4-3-5-13(14)18(21)22/h3-11H,1-2H3,(H,19,20)(H,21,22)/b10-8+
Canonical SMILES
COc1ccc(C=CC(=O)Nc2ccccc2C(=O)O)cc1OC
Isomeric SMILES
COC1=C(C=C(C=C1)/C=C/C(=O)NC2=CC=CC=C2C(=O)O)OC

Synonyms

  • Rizaben
  • Tranilastum
  • N-(3,4-Dimethoxycinnamoyl)anthranilic acid
  • 2-((3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl)amino)benzoic acid
  • 2-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl]amino]benzoic Acid
  • Benzoic acid, 2-((3-(3,4-dimethoxyphenyl)-1-oxo-2-propenyl)amino)-
  • 2-{[(2e)-3-(3,4-Dimethoxyphenyl)prop-2-Enoyl]amino}benzoic Acid
  • 2-(((2E)-3-(3,4-Dimethoxyphenyl)prop-2-enoyl)amino)benzoic acid
  • Benzoic acid, 2-[[3-(3,4-dimethoxyphenyl)-1-oxo-2-propenyl]amino]-
  • N (3', 4'-dimethoxycinnamoyl) anthranilic acid (N-5')
  • 1 N-(3'-4'-dimethoxycinnamoyl) anthranilic acid (N-5'), N(3',4'-dimethoxycinnamoyl) anthranilic acid (N-5')
  • trans-Tranilast
  • 2-[[(E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino]benzoic acid
  • (E)-2-(3-(3,4-dimethoxyphenyl)acrylamido)benzoic acid
  • MK 341
  • Tranilast (trans-)
  • 2-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2-propen-1-yl]amino]benzoic Acid
  • 2-[(2E)-3-(3,4-dimethoxyphenyl)prop-2-enamido]benzoic acid
  • (E)-2-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl]amino]benzoic acid
  • 2-(3-(3,4-dimethoxyphenyl)acrylamido)benzoic acid
  • HSCI1_000076
  • SB 252218
  • 2-[3-(3,4-Dimethoxyphenyl)acrylamido]benzoic Acid
  • Rizaben (TN)
  • n-(3',4'-dimethoxycinnamoyl) anthranilic acid
Show all 30 synonyms
  • (E)-2-[3-(3,4-Dimethoxyphenyl)acrylamido]benzoic Acid
  • Anthranilic acid, N-(3,4-dimethoxycinnamoyl)-
  • MK 341, SB 252218
  • Tranilast Impurity 31
  • 2-(3,4-Dimethoxycinnamoylamino)benzoic Acid

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
327.34 g/molcalc.
Exact mass
327.1107 Dacalc.
LogP (octanol/water)
3.05calc.
Topological polar surface area
84.86 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
6calc.
Heavy atoms
24calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.11calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(C=Cc1ccccc1)Nc1ccccc1

O=C(C=Cc1ccccc1)Nc1ccccc1

2 rings, 17 atoms.

1,928 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
Precautionary statements (5)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P317If swallowed: Get medical help.
  • P330Rinse mouth.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Tranilast suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 41 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

41 suppliers in 10 countries

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Tranilast price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Anti-Allergic Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Calcium Channel Blockers
  • Histamine H1 Antagonists
  • Platelet Aggregation Inhibitors

Roles

  • agonist
  • antagonist
  • anti-allergic agent
  • anti-asthmatic agent
  • anti-asthmatic drug
  • antineoplastic agent
  • antirheumatic drug
  • aryl hydrocarbon receptor agonist
  • biophysical role
  • calcium channel blocker
  • calcium channel modulator
  • hepatoprotective agent
  • membrane transport modulator
  • nephroprotective agent
  • pharmaceutical
  • protective agent

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Tranilast is traded under.

HS 2924.29Indicative HS code

Cyclic amides (including cyclic carbamates) and their derivatives, salts thereof, other

World exports in 2024
$5.69B
−5.1% vs 2023, imports $5.8B
2019 to 2024
Top exporters
  1. China32.3%
  2. Switzerland * partner reported13.6%
  3. Norway * partner reported12.8%
Top importers
  1. United States15.9%
  2. Ireland15.8%
  3. Germany11.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Tranilast is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Tranilast, based on the data on this page

What is Tranilast?

Tranilast is an amidobenzoic acid that is anthranilic acid in which one of the anilino hydrogens is replaced by a 3,4-dimethoxycinnamoyl group.

What is the CAS number of Tranilast?

The CAS registry number of Tranilast is 53902-12-8. Other or deprecated CAS numbers: 53902-17-3, 70806-55-2.

What is the molecular formula and weight of Tranilast?

The molecular formula of Tranilast is C18H17NO5 and its molar mass is 327.34 g/mol.

What is Tranilast used for?

Known uses and roles of Tranilast include anti-inflammatories in pharmaceuticals, antihypertensives in pharmaceuticals, cardiovascular drugs in pharmaceuticals, respiratory and anti-allergy drugs in pharmaceuticals, agonist and 20 more.

Is Tranilast hazardous?

Tranilast carries the GHS signal word "Warning". Main hazards: harmful if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Tranilast?

Tranilast is usually classified under HS code 292429 (Cyclic amides (including cyclic carbamates) and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Tranilast?

CompoundList lists 41 suppliers of Tranilast in China, United States, United Kingdom, Spain and 6 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Tranilast?

Suppliers quote Tranilast on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Tranilast

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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