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Respiratory, allergy and digestive drugs

Trimethobenzamide

Also known as Trimetobenzamida, Trimethobenzamidum, Ametik damla

CAS 138-56-7Formula C21H28N2O5Molar mass 388.46 g/molEC 205-332-1
2 suppliers listed Drug substance
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Trimethobenzamide chemical structure, C21H28N2O5, CAS 138-56-7
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
138-56-7
Formula
C21H28N2O5
Molar mass
388.46 g/mol
Solubility
WHITE CRYSTALLINE POWDER, SLIGHT PHENOLIC ODOR, SOL IN WARM ALC, INSOL IN ETHER & BENZEN…
HS code
292429
Category
Respiratory, allergy and digestive drugs

What is Trimethobenzamide?

Plain description, key identifiers and synonyms

Trimethobenzamide is the amide obtained by formal condensation of 3,4,5-trihydroxybenzoic acid with 4-[2-(N,N-dimethylamino)ethoxy]benzylamine. It is used to prevent nausea and vomitting in humans. It has a role as an antiemetic. It is a member of benzamides and a tertiary amino compound.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4,5-trimethoxybenzamide
CAS number
138-56-7 CAS number cross-checked
EC number
205-332-1
Molecular formula
C21H28N2O5
UNII
W2X096QY97
MDL number
MFCD00599601
InChIKey
FEZBIKUBAYAZIU-UHFFFAOYSA-N
InChI
InChI=1S/C21H28N2O5/c1-23(2)10-11-28-17-8-6-15(7-9-17)14-22-21(24)16-12-18(25-3)20(27-5)19(13-16)26-4/h6-9,12-13H,10-11,14H2,1-5H3,(H,22,24)
SMILES (canonical and isomeric)
CN(C)CCOC1=CC=C(C=C1)CNC(=O)C2=CC(=C(C(=C2)OC)OC)OC

Synonyms

  • Trimetobenzamida
  • Trimethobenzamidum
  • Ametik damla
  • Benzamide, N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4,5-trimethoxy-
  • N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4,5-trimethoxybenzamide
  • 4-(2-Dimethylaminoethoxy)-N-(3,4,5-trimethoxybenzoyl)benzylamine
  • Benzamide, N-(p-(2-(dimethylamino)ethoxy)benzyl)-3,4,5-trimethoxy-
  • N-({4-[2-(dimethylamino)ethoxy]phenyl}methyl)-3,4,5-trimethoxybenzamide
  • Benzamide, N-((4-(2-(dimethylamino)ethoxy)phenyl)methyl)-3,4,5-trimethoxy-
  • N-[[4-(2-dimethylaminoethoxy)phenyl]methyl]-3,4,5-trimethoxybenzamide
  • trimetobenzamide
  • N-((4-(2-(dimethylamino)ethoxy)phenyl)methyl)-3,4,5-trimethoxybenzamide
  • N-((4-(2-dimethylaminoethoxy)phenyl)methyl)-3,4,5-trimethoxybenzamide
  • N-(4-(2-(Dimethylamino)ethoxy)benzyl)-3,4,5-trimethoxybenzamide
  • emedur
  • Tribenzagan
  • Benzacot
  • Stemetic
  • Trimethobenzamide (INN)
  • N-{4-[2-(dimethylamino)ethoxy]benzyl}-3,4,5-trimethoxybenzamide
  • Ametik damla (TN)
  • N-((2-Dimethylaminoethoxy)benzyl)-3,4,5-trimethoxybenzamide
  • DivK1c_000425
  • N-[p-[2-(Dimethylamino)ethoxy]benzyl]-3,4,5-trimethoxybenzamide
  • N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4,5-trimethoxy-benzamide
Show all 26 synonyms
  • N-(4-[2-(Dimethylamino)ethoxy]benzyl)-3,4,5-trimethoxybenzamide #

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Solubility
WHITE CRYSTALLINE POWDER, SLIGHT PHENOLIC ODOR, SOL IN WARM ALC, INSOL IN ETHER & BENZENE /HYDROCHLORIDE/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
388.46 g/molcalc.
Exact mass
388.1998 Dacalc.
LogP (octanol/water)
2.58calc.
Topological polar surface area
69.26 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
10calc.
Heavy atoms
28calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.38calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(NCc1ccccc1)c1ccccc1

O=C(NCc1ccccc1)c1ccccc1

2 rings, 16 atoms, the N-Benzoylbenzylamine ring system.

2,172 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Trimethobenzamide suppliers

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All 2 suppliers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

2 suppliers in 1 country

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Trimethobenzamide price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Veterinary medication:.

Pharmacological actions

  • Antiemetics

Roles

  • antiemetic
  • pharmaceutical

Pharmacology

Trimethobenzamide is an Antiemetic. The physiologic effect of trimethobenzamide is by means of Emesis Suppression.

How it is made

Goldberg, teitel, us patent 2,879,293 (1959 to hoffmann-la roche).

4-[2-(Dimethylamino)ethoxy]benzylamine is condensed with 3,4,5-trimethoxybenzoyl chloride by refluxing in inert solvent. Resulting trimethoxybenzamide may be converted to hydrochloride by dissolving it in suitable solvent & treating with hcl. (Hydrochloride salt)

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Trimethobenzamide is traded under.

HS 2924.29Indicative HS code

Cyclic amides (including cyclic carbamates) and their derivatives, salts thereof, other

World exports in 2024
$5.69B
−5.1% vs 2023, imports $5.8B
2019 to 2024
Top exporters
  1. China32.3%
  2. Switzerland * partner reported13.6%
  3. Norway * partner reported12.8%
Top importers
  1. United States15.9%
  2. Ireland15.8%
  3. Germany11.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Trimethobenzamide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Trimethobenzamide, based on the data on this page

What is Trimethobenzamide?

Trimethobenzamide is the amide obtained by formal condensation of 3,4,5-trihydroxybenzoic acid with 4-[2-(N,N-dimethylamino)ethoxy]benzylamine. It is used to prevent nausea and vomitting in humans. It has a role as an antiemetic. It is a member of benzamides and a tertiary amino compound.

What is the CAS number of Trimethobenzamide?

The CAS registry number of Trimethobenzamide is 138-56-7.

What is the molecular formula and weight of Trimethobenzamide?

The molecular formula of Trimethobenzamide is C21H28N2O5 and its molar mass is 388.46 g/mol.

What is Trimethobenzamide used for?

Veterinary medication:.

Is Trimethobenzamide hazardous?

No GHS hazard classification for Trimethobenzamide is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Trimethobenzamide?

Trimethobenzamide is usually classified under HS code 292429 (Cyclic amides (including cyclic carbamates) and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Trimethobenzamide?

CompoundList lists 2 suppliers of Trimethobenzamide in China. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Trimethobenzamide?

Suppliers quote Trimethobenzamide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Trimethobenzamide

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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