Trimethyl phosphite
Also known as Trimethylphosphite, Trimethoxyphosphine, Methyl phosphite
Key facts
What buyers check first
- Appearance
- Colorless liquid
- Melting point
- -78 °C
- Boiling point
- 110 °C
- Density
- 1.0518 g/cm³ at 20 °C
- Flash point
- 28 °C
- HS code
- 292023
- Category
- Insecticides and acaricides
- UN number
- UN 2329
What is Trimethyl phosphite?
Plain description, key identifiers and synonyms
Trimethyl phosphite is an organophosphorus compound that is phosphane in which the three hydrogens are replaced by methoxy groups. It is an alkylating agent used primarily in the synthesis of organophosphate compounds. It has a role as an alkylating agent.
Identifiers
Registry numbers, names and line notations, tap to copy
- IUPAC name
- trimethyl phosphite
- CAS number
- 121-45-9 CAS number cross-checked
- EC number
- 204-471-5
- Molecular formula
- C3H9O3P
- UNII
- 26Q0321ZDG
- MDL number
- MFCD00008350
- InChIKey
- CYTQBVOFDCPGCX-UHFFFAOYSA-N
- InChI
- InChI=1S/C3H9O3P/c1-4-7(5-2)6-3/h1-3H3
- SMILES (canonical and isomeric)
- COP(OC)OC
Synonyms
- Trimethylphosphite
- Trimethoxyphosphine
- Methyl phosphite
- Phosphorous acid, trimethyl ester
- Trimethylfosfit
- Trimethoxyfosfin
- Fosforyn trojmetylowy
- Trimethyl ester of phosphorous acid
- Phosphorous acid trimethyl ester
- P(OMe)3
- Methyl phosphite ((MeO)3P)
- P(OCH3)3
- Trimethyl Ester Phosphorous Acid, NSC 6513, Trimethoxyphosphine,
- Trimethylphosphit
- TMPhite
- trimethoxyphosphane
- trimethyl-phosphite
- Phosphorous acid,trimethyl ester
- Trimethoxyphosphine-d9
- Methanol Phosphite-d9
- Trimethyl phosphite, 97%
- Trimethyl phosphite, >=97%
- Trimethyl phosphite, >=99%
- UN 2329
- Trimethyl phosphite [UN2329] [Flammable liquid]
Show all 27 synonymsShow fewer synonyms
- Trimethyl phosphite Solution in Methanol, 100ug/mL
- Trimethyl phosphite, >=99.999% trace metals basis
Physical and chemical properties
Measured values and descriptors computed from the structure
Physical and chemical properties
Measured values, check the supplier specification for your grade
| Appearance | Colorless liquidexp.Measured value |
|---|---|
| Odour | Irritating, pungent, oily, pyridine-like odorexp.Measured value |
| Melting point | -78 °Cexp.Measured value |
| Boiling point | 110 °Cexp.Measured value |
| Density | 1.0518 g/cm³ at 20 °Cexp.Measured value |
| Flash point | 28 °Cexp.Measured value |
| Autoignition temperature | 250 °Cexp.Measured value |
| Solubility | Reacts (hydrolyzes) with waterexp.Measured value |
| Vapour pressure | 24 torr at 25 °C (saturates in air at 32,000 ppm)exp.Measured value |
Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.
Computed descriptors
Calculated from the structure, useful for screening and formulation
| Molecular weight | 124.08 g/molcalc.Computed value |
|---|---|
| Exact mass | 124.0289 Dacalc.Computed value |
| LogP (octanol/water) | 1.15calc.Computed value |
| Topological polar surface area | 27.69 Ųcalc.Computed value |
| Hydrogen bond donors | 0calc.Computed value |
| Hydrogen bond acceptors | 3calc.Computed value |
| Rotatable bonds | 3calc.Computed value |
| Heavy atoms | 7calc.Computed value |
| Rings | 0calc.Computed value |
| Aromatic rings | 0calc.Computed value |
| Fraction sp3 carbons | 1calc.Computed value |
| Formal charge | 0calc.Computed value |
| Stereocentres | 0calc.Computed value |
| Lipinski rule of five | Passes (0 violations)calc.Computed value |
Calculated for screening. Confirm critical figures with the supplier.
Safety and hazards
GHS classification summary, not a safety data sheet
Hazard statements
- H226Flammable liquid and vapour.
- H302Harmful if swallowed.
- H312Harmful in contact with skin.
- H315Causes skin irritation.
- H318Causes serious eye damage.
- H319Causes serious eye irritation.
- H332Harmful if inhaled.
- H335May cause respiratory irritation.
- H361Suspected of damaging fertility or the unborn child.
Precautionary statements (32)
- P203Obtain, read and follow all safety instructions before use.
- P210Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
- P233Keep container tightly closed.
- P240Ground and bond container and receiving equipment.
- P241Use explosion-proof electrical, ventilating and lighting equipment.
- P242Use non-sparking tools.
- P243Take action to prevent static discharges.
- P261Avoid breathing dust, fume, gas, mist, vapours or spray.
- P264Wash skin thoroughly after handling.
- P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
- P270Do not eat, drink or smoke when using this product.
- P271Use only outdoors or in a well-ventilated area.
- P280Wear protective gloves, protective clothing, eye protection and face protection.
- P301 + P317If swallowed: Get medical help.
- P302 + P352If on skin: Wash with plenty of water.
- P303 + P361 + P353If on skin (or hair): Take off immediately all contaminated clothing. Rinse skin with water or shower.
- P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
- P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
- P305 + P354 + P338If in eyes: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
- P317Get medical help.
- P318If exposed or concerned, get medical advice.
- P319Get medical help if you feel unwell.
- P321Specific treatment (see supplemental first aid instructions on the label).
- P330Rinse mouth.
- P332 + P317If skin irritation occurs: Get medical help.
- P337 + P317If eye irritation persists: Get medical help.
- P362 + P364Take off contaminated clothing. And wash it before reuse.
- P370 + P378In case of fire: Use appropriate media to extinguish.
- P403 + P233Store in a well-ventilated place. Keep container tightly closed.
- P403 + P235Store in a well-ventilated place. Keep cool.
- P405Store locked up.
- P501Dispose of contents and container in accordance with local regulations.
- UN number
- UN 2329
- Transport hazard class
- 3
- Packing group
- III
GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.
Full safety data and first aidTrimethyl phosphite suppliers
Controlled substance, listings of documented suppliers only, in the documented ranking
Trimethyl phosphite is controlled. Only documented suppliers can list it, and buyers must upload a valid licence with their request. Every request is reviewed before suppliers see it.
Licensed buyers only, every enquiry is reviewed by our compliance team.
Reference: OPCW Chemical Weapons Convention Schedule 3, HS 2022 subheading 2920.23 (trimethyl phosphite)
Our policy on controlled substancesLicensed buyers can post a request for Trimethyl phosphite with their licence. Our compliance team reviews it before suppliers see it.
Trimethyl phosphite price
Indicative price range per kg from live supplier offers
Suppliers quote this chemical on request. Send one free request and compare quotes side by side.
Uses and applications
What the substance is used for, by industry and function
Precursor to DMMP (Dimethylmethyl phosphonate).
Trimethyl phosphite has been used primarily as an intermediate in the manufacture of pesticides. It is also used as a fireproofing agent in the production of textiles, as an intermediate in the production of flame-retardant polymers for polyurethane foams, and as a catalyst.
Liquid phosphorus source used in the deposition of phosphosilicate glass (PSG).
Chemical intermediate, especially for insecticides.
Industrial uses: Lubricating agent, UV stabilizer, Intermediate.
Consumer uses: Lubricating agent.
Industries and functions
Roles
- aetiopathogenetic role
- alkylating agent
- genotoxin
- mutagen
How it is made
Reaction of phosphorus trichloride and methyl alcohol in presence of a tertiary amine
Methanol + phosphorus trichloride (dehydrochlorination)
Synthesis: Phosphorus trichloride and methanol. Catalyst: Diethylaniline, petroleum ether.
Regulatory status
Inventories, regulations and trade controls that list this substance
Trimethyl phosphite is controlled. Only documented suppliers can list it, and buyers must upload a valid licence with their request. Every request is reviewed before suppliers see it.
Licensed buyers only, every enquiry is reviewed by our compliance team.
Reference: OPCW Chemical Weapons Convention Schedule 3, HS 2022 subheading 2920.23 (trimethyl phosphite)
Our policy on controlled substancesControls
- Chemical Weapons Convention Schedule 3
United States
- TSCA inventory (USA)Status: Active in US commerce
HS code and trade data
Customs classification and reported world trade statistics
Global trade
World import and export statistics for the HS code Trimethyl phosphite is traded under.
Esters: phosphite esters and their salts, their halogenated, sulphonated, nitrated or nitrosated derivatives…
- India * partner reported78.0%
- China8.8%
- United States7.8%
- United States67.4%
- United Kingdom14.7%
- South Korea4.1%
* Partner reported figures, a lower bound.
The HS code shown for Trimethyl phosphite is indicative (it was matched by name in the HS nomenclature). Confirm the classification with your customs broker before shipping.
Related chemicals
Parent and salt forms, stereoisomers, similar structures and isomers
Salt and hydrate forms
Records that share this compound as their parent
Stereoisomers and isotopic forms
Same connectivity, different stereochemistry or isotopes (same InChIKey skeleton)
Same formula isomers
Different compounds that share this molecular formula
Frequently asked questions
Quick answers about Trimethyl phosphite, based on the data on this page
What is Trimethyl phosphite?
What is the CAS number of Trimethyl phosphite?
What is the molecular formula and weight of Trimethyl phosphite?
What is Trimethyl phosphite used for?
Is Trimethyl phosphite hazardous?
What is the HS code of Trimethyl phosphite?
Can I buy Trimethyl phosphite on CompoundList?
Guides for buyers
Practical guides that help when you source, ship or handle Trimethyl phosphite
- Guide, SafetyHow to read a safety data sheet in 10 minutesA section by section method to pull the essentials out of any 16 section SDS: identity, hazards, composition, storage, PPE, properties, transport and emergency measures.Read
- Guide, Trade and logisticsShipping dangerous goods: UN numbers, classes and packing groupsHow the UN dangerous goods system works for chemicals, from the nine classes and UN numbers to packing groups, UN packaging marks, labels, documents and segregation.Read
- Guide, SafetyGHS pictograms, signal words and hazard statements explainedA practical guide to the nine GHS pictograms, the signal words Danger and Warning, H and P statements, and how to read a chemical label in seconds.Read
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