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Pharmaceuticals and APIs

Vadadustat

Also known as Vafseo, N-(5-(3-Chlorophenyl)-3-hydroxypyridine-2-carbonyl)glycine, 2-[[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino]acetic acid

CAS 1000025-07-9Formula C14H11ClN2O4Molar mass 306.71 g/molEC 815-079-4
GHS signal word: Warning. Pictograms: Harmful or irritant, Serious health hazard 16 suppliers listed Drug substance
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Vadadustat chemical structure, C14H11ClN2O4, CAS 1000025-07-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
1000025-07-9
Formula
C14H11ClN2O4
Molar mass
306.71 g/mol
EC number
815-079-4
HS code
293339
Category
Pharmaceuticals and APIs

What is Vadadustat?

Plain description, key identifiers and synonyms

Vadadustat is an orally bioavailable, hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor (HIF-PHI), with potential anti-anemic and anti-inflammatory activities. Upon administration, vadadustat binds to and inhibits HIF-PH, an enzyme responsible for the degradation of transcription factors in the HIF family under normal oxygen conditions. This prevents HIF breakdown and promotes HIF activity. Increased HIF activity leads to an increase in endogenous erythropoietin production, thereby enhancing erythropoiesis. It also reduces the expression of the peptide hormone hepcidin, improves iron availability, and boosts hemoglobin (Hb) levels. HIF regulates the expression of genes in response to reduced oxygen levels, including genes required for erythropoiesis and iron metabolism. In addition, HIF 1-alpha (HIF1A) may play a role in reducing inflammation during acute lung injury (ALI) through HIF-dependent control of glucose metabolism in the alveolar epithelium.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-[[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino]acetic acid
CAS number
1000025-07-9
EC number
815-079-4
Molecular formula
C14H11ClN2O4
UNII
I60W9520VV
MDL number
MFCD30470233
InChIKey
JGRXMPYUTJLTKT-UHFFFAOYSA-N
InChI
InChI=1S/C14H11ClN2O4/c15-10-3-1-2-8(4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
SMILES (canonical and isomeric)
C1=CC(=CC(=C1)Cl)C2=CC(=C(N=C2)C(=O)NCC(=O)O)O

Synonyms

  • Vafseo
  • N-(5-(3-Chlorophenyl)-3-hydroxypyridine-2-carbonyl)glycine
  • 2-[[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino]acetic acid
  • 2-{[5-(3-chlorophenyl)-3-hydroxypyridin-2-yl]formamido}acetic acid
  • Glycine, N-((5-(3-chlorophenyl)-3-hydroxy-2-pyridinyl)carbonyl)-
  • Glycine, N-[[5-(3-chlorophenyl)-3-hydroxy-2-pyridinyl]carbonyl]-
  • N-[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]glycine
  • N-[[5-(3-Chlorophenyl)-3-hydroxy-2-pyridinyl]carbonyl]glycine
  • vadadustatum
  • N-((5-(3-Chlorophenyl)-3-hydroxy-2-pyridinyl)carbonyl)glycine
  • 2-((5-(3-chlorophenyl)-3-hydroxypyridin-2-yl)formamido)acetic acid
  • 2-((5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl)amino)acetic acid
  • (5-(3-chlorophenyl)-3-hydroxypicolinoyl)glycine
  • Glycine, N-[[5-(3-chlorophenyl)-3-hydroxy-2-pyridinyl]carbonyl]-, Glycine, N-[[5-(3-chlorophenyl)-3-hydroxy-2-pyridinyl]carbonyl]-
  • Vadadustat?
  • US8722895, 11: {[5-(3-Chlorophenyl)-3-hydroxypyridine-2- carbonyl]amino}-acetic acid
  • Vafseo (TN)
  • US8722895, 10: {[5-(3-Chlorophenyl)-3-hydroxypyridine-2- carbonyl]amino}-acetic acid trifluoroacetic acid salt
  • Vadadustat (JAN/USAN/INN)
  • US8598210, Table XV, 10
  • US8598210, Table XV, 11
  • Vadadustat, PG-1016548, AKB-6548
  • US8598210, 119
  • 2-(5-(3-Chlorophenyl)-3-hydroxypicolinamido)acetic acid
  • AKB-6548, B-506, PG-1016548
Show all 28 synonyms
  • {[5-(3-chlorophenyl)-3-hydroxy-pyridine-2-carbonyl]-amino}-acetic acid
  • {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}-acetic acid
  • 2-[[5-(3-chlorophenyl)-3-hydroxy-pyridine-2-carbonyl]amino]acetic acid

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
306.71 g/molcalc.
Exact mass
306.0407 Dacalc.
LogP (octanol/water)
1.92calc.
Topological polar surface area
99.52 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
4calc.
Heavy atoms
21calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.07calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(-c2cccnc2)cc1

c1ccc(-c2cccnc2)cc1

2 rings, 12 atoms, the 3-Phenylpyridine ring system.

7,366 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H302Harmful if swallowed.
  • H373May cause damage to organs through prolonged or repeated exposure.
Precautionary statements (7)
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P317If swallowed: Get medical help.
  • P319Get medical help if you feel unwell.
  • P330Rinse mouth.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Vadadustat suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 16 suppliers
16 of 16 offers

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Where suppliers are based

16 suppliers in 5 countries

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Vadadustat price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Prolyl-Hydroxylase Inhibitors

Roles

  • anti-anaemic agent

Pharmacology

Vadadustat is a Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitor. The mechanism of action of vadadustat is as a Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor, and Breast Cancer Resistance Protein Inhibitor, and Organic Anion Transporter 3 Inhibitor.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Vadadustat is traded under.

HS 2933.39Indicative HS code

Heterocyclic compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure…

World exports in 2024
$9.16B
−17.9% vs 2023, imports $10.6B
2019 to 2024
Top exporters
  1. China21.5%
  2. India * partner reported12.3%
  3. Ireland11.6%
Top importers
  1. Germany14.2%
  2. United States12.8%
  3. Brazil10.1%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Vadadustat is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Vadadustat, based on the data on this page

What is Vadadustat?

Vadadustat is an orally bioavailable, hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor (HIF-PHI), with potential anti-anemic and anti-inflammatory activities.

What is the CAS number of Vadadustat?

The CAS registry number of Vadadustat is 1000025-07-9.

What is the molecular formula and weight of Vadadustat?

The molecular formula of Vadadustat is C14H11ClN2O4 and its molar mass is 306.71 g/mol.

What is Vadadustat used for?

Known uses and roles of Vadadustat include anti-anaemic agent and prolyl-hydroxylase inhibitors.

Is Vadadustat hazardous?

Vadadustat carries the GHS signal word "Warning". Main hazards: harmful if swallowed, may cause damage to organs through prolonged or repeated exposure. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Vadadustat?

Vadadustat is usually classified under HS code 293339 (Compounds containing an unfused pyridine ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Vadadustat?

CompoundList lists 16 suppliers of Vadadustat in China, United States, Canada, Germany and 1 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Vadadustat in India?

1 supplier in India list Vadadustat on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Vadadustat?

Suppliers quote Vadadustat on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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