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Screening compounds

Vesnarinone

Also known as Arkin-Z, Arkin, Vesnarinona

CAS 81840-15-5Formula C22H25N3O4Molar mass 395.46 g/mol
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Vesnarinone chemical structure, C22H25N3O4, CAS 81840-15-5
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
81840-15-5
Formula
C22H25N3O4
Molar mass
395.46 g/mol
HS code
293359
Category
Screening compounds

What is Vesnarinone?

Plain description, key identifiers and synonyms

Arkin (TN) is an organic molecular entity.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
6-[4-(3,4-dimethoxybenzoyl)piperazin-1-yl]-3,4-dihydro-1H-quinolin-2-one
CAS number
81840-15-5 CAS number cross-checked
Molecular formula
C22H25N3O4
UNII
5COW40EV8M
MDL number
MFCD00867124
InChIKey
ZVNYJIZDIRKMBF-UHFFFAOYSA-N
InChI
InChI=1S/C22H25N3O4/c1-28-19-7-3-16(14-20(19)29-2)22(27)25-11-9-24(10-12-25)17-5-6-18-15(13-17)4-8-21(26)23-18/h3,5-7,13-14H,4,8-12H2,1-2H3,(H,23,26)
SMILES (canonical and isomeric)
COC1=C(C=C(C=C1)C(=O)N2CCN(CC2)C3=CC4=C(C=C3)NC(=O)CC4)OC

Synonyms

  • Arkin-Z
  • Arkin
  • Vesnarinona
  • Arkin Z
  • Vesnarinonum
  • 1-(3,4-Dimethoxybenzoyl)-4-(1,2,3,4-tetrahydro-2-oxo-6-quinolinyl)piperazine
  • pieranometazine
  • 6-(4-((3,4-dimethoxyphenyl)carbonyl)piperazin-1-yl)-1,2,3,4-tetrahydroquinolin-2-one
  • 6-{4-[(3,4-dimethoxyphenyl)carbonyl]piperazin-1-yl}-1,2,3,4-tetrahydroquinolin-2-one
  • 3,4-dihydro-6-(4-(3,4-dimethoxybenzoyl)-1-piperazinyl)-2-1H-quinolinone
  • 3,4-Dihydro-6-(4-(3,4-dimethoxybenzoyl)-1-pip-erazinyl)-2(1H)-quinolinone
  • Piperazine, 1-(3,4-dimethoxybenzoyl)-4-(1,2,3,4-tetrahydr-o-2-oxo-6-quinolinyl)
  • Piteranometozine
  • 6-[4-(3,4-dimethoxybenzoyl)piperazin-1-yl]-3,4-dihydro-1H-quinolin-2-one
  • 6-(4-(3,4-dimethoxybenzoyl)piperazin-1-yl)-3,4-dihydroquinolin-2(1H)-one
  • Piperazine, 1-(3,4-dimethoxybenzoyl)-4-(1,2,3,4-tetrahydro-2-oxo-6-quinolinyl)-
  • 6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-3,4-dihydro-2(1h)-quinolinone
  • 6-[4-(3,4-Dimethoxybenzoyl)piperazin-1-yl]-3,4-dihydroquinolin-2(1H)-one
  • Arkin (TN)
  • Arkin Z (TN)
  • 1-(1,2,3,4-Tetrahydro-2-oxo-6-quinolyl)-4-veratroylpiperazine
  • 6-(4-(3,4-Dimethoxybenzoyl)-1-piperazinyl)-3,4-dihydro-2(1H)-
  • Vesnarinone(OPC8212)?
  • 3,4-Dihydro-6-(4-(3,4-dimethoxybenzoyl)-1-piperazinyl)-2(1H)-quinolinone
  • Vesnarinone (JAN/USAN/INN)
Show all 26 synonyms
  • OPC-8212, Piteranometozine, Arkin

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
395.46 g/molcalc.
Exact mass
395.1845 Dacalc.
LogP (octanol/water)
2.55calc.
Topological polar surface area
71.11 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
4calc.
Heavy atoms
29calc.
Rings
4calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.36calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CCc2cc(N3CCN(C(=O)c4ccccc4)CC3)ccc2N1

O=C1CCc2cc(N3CCN(C(=O)c4ccccc4)CC3)ccc2N1

4 rings, 25 atoms.

1 other chemical share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Vesnarinone suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 4 suppliers
4 of 4 offers

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Where suppliers are based

4 suppliers in 2 countries

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Vesnarinone price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Adjuvants, Immunologic
  • Antineoplastic Agents
  • Antiviral Agents
  • Cardiotonic Agents
  • Phosphodiesterase Inhibitors

Roles

  • anti-HIV agent
  • antimicrobial agent
  • antiviral agent

Pharmacology

Vesnarinone is a cardiotonic quinolinone derivative, that suppresses cell proliferation and induces apoptosis by inducing the expression of p21, an inhibitor of cyclin dependent kinase activity in p53-mediated cell cycle arrest. (NCI)

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Vesnarinone is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Vesnarinone is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Vesnarinone, based on the data on this page

What is Vesnarinone?

Arkin (TN) is an organic molecular entity.

Guides for buyers

Practical guides that help when you source, ship or handle Vesnarinone

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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