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Central nervous system drugs

Vortioxetine

Also known as Lu AA21004, vortioxetina, 1-{2-[(2,4-dimethylphenyl)sulfanyl]phenyl}piperazine

CAS 508233-74-7Formula C18H22N2SMolar mass 298.46 g/molEC 823-919-6
GHS signal word: Warning. Pictograms: Harmful or irritant, Serious health hazard, Hazardous to the environment 94 suppliers listed Drug substance
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Vortioxetine chemical structure, C18H22N2S, CAS 508233-74-7
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
508233-74-7
Formula
C18H22N2S
Molar mass
298.46 g/mol
EC number
823-919-6
HS code
293359
Category
Central nervous system drugs

What is Vortioxetine?

Plain description, key identifiers and synonyms

Vortioxetine is an N-arylpiperazine in which the aryl group is specified as 2-[(2,4-dimethylphenyl)sulfanyl]phenyl. Used (as its hydrobromide salt) for treatment of major depressive disorder. It has a role as an antidepressant, an anxiolytic drug, a serotonergic agonist and a serotonergic antagonist. It is an aryl sulfide and a N-arylpiperazine. It is a conjugate base of a vortioxetine(1+).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1-[2-(2,4-dimethylphenyl)sulfanylphenyl]piperazine
CAS number
508233-74-7 CAS number cross-checked
EC number
823-919-6
Molecular formula
C18H22N2S
UNII
3O2K1S3WQV
MDL number
MFCD22380814
InChIKey
YQNWZWMKLDQSAC-UHFFFAOYSA-N
InChI
InChI=1S/C18H22N2S/c1-14-7-8-17(15(2)13-14)21-18-6-4-3-5-16(18)20-11-9-19-10-12-20/h3-8,13,19H,9-12H2,1-2H3
SMILES (canonical and isomeric)
CC1=CC(=C(C=C1)SC2=CC=CC=C2N3CCNCC3)C

Synonyms

  • Lu AA21004
  • vortioxetina
  • 1-{2-[(2,4-dimethylphenyl)sulfanyl]phenyl}piperazine
  • vortioxetinum
  • Lu-AA21004
  • Piperazine, 1-[2-[(2,4-dimethylphenyl)thio]phenyl]-
  • Piperazine, 1-(2-((2,4-dimethylphenyl)thio)phenyl)-
  • 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine
  • 1-(2-(2,4-dimethylphenylsulfanyl)phenyl)piperazine
  • 1-(2-((2,4-Dimethylphenyl)sulfanyl)phenyl}piperazine
  • 1-(2-((2,4-Dimethylphenyl)sulfanyl)phenyl)piperazine
  • 1-(2-((2,4-Dimethylphenyl)thio)phenyl)piperazine
  • Vortioxetine free base
  • 1-[2-(2,4-dimethylphenyl)sulfanylphenyl]piperazine
  • 1-[2-[(2,4-Dimethylphenyl)thio]phenyl]piperazine
  • Lu AA 21004
  • Vortioxetine (USAN)
  • Brintellix (TN)
  • 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazine
  • Piperazine, 1-[2-[(2,4-dimethylphenyl)thio]phenyl]-, 1-[2-(2,4-Dimethylphenylsulfanyl)phenyl]piperazine, Lu AA 21004, Vortioxetine
  • VTX
  • 508233-74-7 (free base)
  • PS37 - Vortioxetine
  • Vortioxetine (Standard)
  • Vortioxetine, Lu AA21004
Show all 28 synonyms
  • Vortioxetine (Lu AA21004)
  • Vortioxetine (Lu AA21004)?
  • 1-[2-(2,4-dimethylphenylsulfanyl)ph

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
298.46 g/molcalc.
Exact mass
298.1504 Dacalc.
LogP (octanol/water)
3.86calc.
Topological polar surface area
15.27 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
3calc.
Heavy atoms
21calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.33calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(Sc2ccccc2N2CCNCC2)cc1

c1ccc(Sc2ccccc2N2CCNCC2)cc1

3 rings, 19 atoms, the Vortioxetine impurity 38 ring system.

35 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H302Harmful if swallowed.
  • H361Suspected of damaging fertility or the unborn child.
  • H361dSuspected of damaging the unborn child.
  • H371May cause damage to organs.
  • H373May cause damage to organs through prolonged or repeated exposure.
  • H400Very toxic to aquatic life.
  • H410Very toxic to aquatic life with long lasting effects.
Precautionary statements (14)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P308 + P316If exposed or concerned: Get emergency medical help immediately.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P330Rinse mouth.
  • P391Collect spillage.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Vortioxetine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 94 suppliers
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Where suppliers are based

94 suppliers in 19 countries

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Vortioxetine price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Anti-Anxiety Agents, Serotonin 5-HT1 Receptor Agonists, Serotonin 5-HT1 Receptor Antagonists, Serotonin 5-HT3 Receptor Antagonists, Serotonin Uptake Inhibitors.

Industries and functions

Pharmacological actions

  • Anti-Anxiety Agents
  • Antidepressive Agents
  • Selective Serotonin Reuptake Inhibitors
  • Serotonin 5-HT1 Receptor Agonists
  • Serotonin 5-HT3 Receptor Antagonists

Roles

  • antidepressant
  • antipsychotic agent
  • anxiolytic drug
  • central nervous system depressant
  • central nervous system drug
  • neurotransmitter agent
  • pharmaceutical
  • psychotropic drug
  • serotonergic agonist
  • serotonergic antagonist
  • serotonergic drug
  • tranquilizing drug

Pharmacology

Vortioxetine is a serotonergic antidepressant used for major depression disorders. Vortioxetine has been associated with a low rate of minor serum aminotransferase elevations during treatment, but has not been linked to instances of clinically apparent acute liver injury.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Vortioxetine is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Vortioxetine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Vortioxetine, based on the data on this page

What is Vortioxetine?

Vortioxetine is an N-arylpiperazine in which the aryl group is specified as 2-[(2,4-dimethylphenyl)sulfanyl]phenyl. Used (as its hydrobromide salt) for treatment of major depressive disorder. It has a role as an antidepressant, an anxiolytic drug, a serotonergic agonist and a serotonergic antagonist.

What is the CAS number of Vortioxetine?

The CAS registry number of Vortioxetine is 508233-74-7.

What is the molecular formula and weight of Vortioxetine?

The molecular formula of Vortioxetine is C18H22N2S and its molar mass is 298.46 g/mol.

What is Vortioxetine used for?

Anti-Anxiety Agents, Serotonin 5-HT1 Receptor Agonists, Serotonin 5-HT1 Receptor Antagonists, Serotonin 5-HT3 Receptor Antagonists, Serotonin Uptake Inhibitors.

Is Vortioxetine hazardous?

Vortioxetine carries the GHS signal word "Warning". Main hazards: harmful if swallowed, suspected of damaging fertility or the unborn child, suspected of damaging the unborn child. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Vortioxetine?

Vortioxetine is usually classified under HS code 293359 (Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Vortioxetine?

CompoundList lists 94 suppliers of Vortioxetine in China, United States, India, United Kingdom and 15 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Vortioxetine in India?

9 suppliers in India list Vortioxetine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Vortioxetine?

Suppliers quote Vortioxetine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Vortioxetine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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