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Screening compounds

WP-1066

Also known as (S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamide, WP 1066, (E)-3-(6-bromopyridin-2-yl)-2-cyano-N-[(1S)-1-phenylethyl]prop-2-enamide

CAS 857064-38-1Formula C17H14BrN3OMolar mass 356.22 g/molEC 632-919-3
GHS signal word: Warning. Pictograms: Harmful or irritant 7 suppliers listed
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WP-1066 chemical structure, C17H14BrN3O, CAS 857064-38-1
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
857064-38-1
Formula
C17H14BrN3O
Molar mass
356.22 g/mol
EC number
632-919-3
HS code
293339
Category
Screening compounds

What is WP-1066?

Plain description, key identifiers and synonyms

WP1066 is an organic molecular entity. It has a role as a STAT3 inhibitor.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(E)-3-(6-bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethyl]prop-2-enamide
CAS number
857064-38-1 CAS number cross-checked
EC number
632-919-3
Molecular formula
C17H14BrN3O
UNII
63V8AIE65T
MDL number
MFCD12912450
InChIKey
VFUAJMPDXIRPKO-LQELWAHVSA-N
InChI
InChI=1S/C17H14BrN3O/c1-12(13-6-3-2-4-7-13)20-17(22)14(11-19)10-15-8-5-9-16(18)21-15/h2-10,12H,1H3,(H,20,22)/b14-10+/t12-/m0/s1
Canonical SMILES
CC(NC(=O)C(C#N)=Cc1cccc(Br)n1)c1ccccc1
Isomeric SMILES
C[C@@H](C1=CC=CC=C1)NC(=O)/C(=C/C2=NC(=CC=C2)Br)/C#N

Synonyms

  • (S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamide
  • WP 1066
  • (E)-3-(6-bromopyridin-2-yl)-2-cyano-N-[(1S)-1-phenylethyl]prop-2-enamide
  • 2-Propenamide, 3-(6-bromo-2-pyridinyl)-2-cyano-N-((1S)-1-phenylethyl)-, (2E)-
  • (2E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-[(1S)-1-phenylethyl]prop-2-enamide
  • (2E)-3-(6-bromopyridin-2-yl)-2-cyano-N-((1S)-1-phenylethyl)prop-2-enamide
  • (E)-3-(6-bromopyridin-2-yl)-2-cyano-N-((1S)-1-phenylethyl)prop-2-enamide
  • Stat3 inhibitor wp1066
  • wp1066STAT Inhibitor III
  • (2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethyl]-2-propenamide
  • Sdccgsbi-0634628.p003
  • (S,E)-3-(6-Bromo-2-pyridyl)-2-cyano-N-(1-phenylethyl)acrylamide
  • (E)-3-(6-bromo-2-pyridyl)-2-cyano-N-[(1S)-1-phenylethyl]prop-2-enamide
  • (E)-3-(6-Pyridin-2-yl)-2-cyano-N-[(1S)-1-phenylethyl]prop-2-enamide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
356.22 g/molcalc.
Exact mass
355.032 Dacalc.
LogP (octanol/water)
3.63calc.
Topological polar surface area
65.78 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
4calc.
Heavy atoms
22calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.12calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(C=Cc1ccccn1)NCc1ccccc1

O=C(C=Cc1ccccn1)NCc1ccccc1

2 rings, 18 atoms.

3 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
Precautionary statements (5)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P317If swallowed: Get medical help.
  • P330Rinse mouth.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

WP-1066 suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 7 suppliers
7 of 7 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

7 suppliers in 2 countries

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WP-1066 price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Roles

  • STAT3 inhibitor

Pharmacology

STAT3 Inhibitor WP1066 is an orally bioavailable, small molecule inhibitor of signaling transducer and activator 3 (STAT3), with potential antineoplastic and immunomodulatory activities. Upon administration, STAT3 inhibitor WP1066 blocks the intranuclear translocation of p-STAT, thereby suppressing STAT3 signaling and decreasing the levels of downstream products including c-Myc.

Read more

Additionally, WP1066 may upregulate costimulatory molecules including CD80 and CD86 on human microglia, and reverse glioma cancer stem cell (gCSC)-mediated innate and adaptive immune suppression allowing for the restoration of antitumor effector immune responses. The STAT3 pathway is overly active in many cancer types and is implicated in CSC-mediated growth, recurrence and resistance to conventional chemotherapies.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code WP-1066 is traded under.

HS 2933.39Indicative HS code

Heterocyclic compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure…

World exports in 2024
$9.16B
−17.9% vs 2023, imports $10.6B
2019 to 2024
Top exporters
  1. China21.5%
  2. India * partner reported12.3%
  3. Ireland11.6%
Top importers
  1. Germany14.2%
  2. United States12.8%
  3. Brazil10.1%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for WP-1066 is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about WP-1066, based on the data on this page

What is WP-1066?

WP1066 is an organic molecular entity. It has a role as a STAT3 inhibitor.

What is the CAS number of WP-1066?

The CAS registry number of WP-1066 is 857064-38-1.

What is the molecular formula and weight of WP-1066?

The molecular formula of WP-1066 is C17H14BrN3O and its molar mass is 356.22 g/mol.

What is WP-1066 used for?

Known uses and roles of WP-1066 include building blocks in research and laboratory, screening compounds in research and laboratory and stat3 inhibitor.

Is WP-1066 hazardous?

WP-1066 carries the GHS signal word "Warning". Main hazards: harmful if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of WP-1066?

WP-1066 is usually classified under HS code 293339 (Compounds containing an unfused pyridine ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy WP-1066?

CompoundList lists 7 suppliers of WP-1066 in China and United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of WP-1066?

Suppliers quote WP-1066 on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle WP-1066

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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