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Screening compounds

Zibotentan

Also known as N-(3-Methoxy-5-methylpyrazin-2-yl)-2-[4-(1,3,4-oxadiazol-2-yl)phenyl]pyridine-3-sulfonamide, Zd 4054, 3-Pyridinesulfonamide, N-(3-methoxy-5-methylpyrazinyl)-2-(4-(1,3,4-oxadiazol-2-yl)phenyl)-

CAS 186497-07-4Formula C19H16N6O4SMolar mass 424.44 g/molEC 643-052-5
GHS signal word: Danger. Pictograms: Harmful or irritant, Serious health hazard, Hazardous to the environment 9 suppliers listed
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Zibotentan chemical structure, C19H16N6O4S, CAS 186497-07-4
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
186497-07-4
Formula
C19H16N6O4S
Molar mass
424.44 g/mol
EC number
643-052-5
HS code
293590
Category
Screening compounds

What is Zibotentan?

Plain description, key identifiers and synonyms

Zibotentan is a member of the class of pyridinesulfonamides that is benzene substituted by 3-[(3-methoxy-5-methylpyrazin-2-yl)sulfamoyl]pyridin-2-yl and 1,3,4-oxadiazol-2-yl groups at positions 1 and 4, respectively. It is an endothelin A receptor antagonist with potential antineoplastic activity. It has a role as an antineoplastic agent, an antihypertensive agent and an endothelin A receptor antagonist. It is a member of benzenes, an aromatic ether, a phenylpyridine, a member of pyrazines, a member of 1,3,4-oxadiazoles and a pyridinesulfonamide.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-(3-methoxy-5-methylpyrazin-2-yl)-2-[4-(1,3,4-oxadiazol-2-yl)phenyl]pyridine-3-sulfonamide
CAS number
186497-07-4 CAS number cross-checked
EC number
643-052-5
Molecular formula
C19H16N6O4S
UNII
8054MM4902
MDL number
MFCD09955343
InChIKey
FJHHZXWJVIEFGJ-UHFFFAOYSA-N
InChI
InChI=1S/C19H16N6O4S/c1-12-10-21-17(19(23-12)28-2)25-30(26,27)15-4-3-9-20-16(15)13-5-7-14(8-6-13)18-24-22-11-29-18/h3-11H,1-2H3,(H,21,25)
SMILES (canonical and isomeric)
CC1=CN=C(C(=N1)OC)NS(=O)(=O)C2=C(N=CC=C2)C3=CC=C(C=C3)C4=NN=CO4

Synonyms

  • N-(3-Methoxy-5-methylpyrazin-2-yl)-2-[4-(1,3,4-oxadiazol-2-yl)phenyl]pyridine-3-sulfonamide
  • Zd 4054
  • 3-Pyridinesulfonamide, N-(3-methoxy-5-methylpyrazinyl)-2-(4-(1,3,4-oxadiazol-2-yl)phenyl)-
  • N-(3-Methoxy-5-methylpyrazin-2-yl)-2-(4-(1,3,4-oxadiazol-2-yl)phenyl)pridine-3-sulfonamide
  • zibotentanum
  • N-(3-Methoxy-5-methylpyrazin-2-yl)-2-(4-(1,3,4-oxadiazol-2-yl)phenyl)pyridine-3-sulfonamide
  • N-(3-Methoxy-5-Methylpyrazin-2-Yl)-2-(4-[1,3,4-Oxadiazol-2-Yl]Phenyl)Pyridine-3-Sulfonamide
  • Zibotentan (ZD4054)
  • 2-(4-(1,3,4-oxadiazol-2-yl)phenyl)-N-(3-methoxy-5-methylpyrazin-2-yl)pyridine-3-sulfonamide
  • Zibotentan (ZD4054 )
  • N-(3-Methoxy-5-methyl-2-pyrazinyl)-2-[4-(1,3,4-oxadiazol-2-yl)phenyl]-3-pyridinesulfonamide
  • N-(3-methoxy-5-methyl-pyrazin-2-yl)-2-[4-(1,3,4-oxadiazol-2-yl)phenyl]pyridine-3-sulfonamide
  • Zibotentan,ZD4054
  • ZibotentanZD4054?
  • ZD4054 Form 1
  • Zibotentan (JAN/USAN/INN)
  • Zibotentan, >=98% (HPLC)
  • 2-[4-(1,3,4-Oxadiazol-2-yl)phenyl]-N-(3-methoxy-5-methyl-2-pyrazinyl)pyridine-3-sulfonamide
  • 3-Pyridinesulfonamide, N-(3-methoxy-5-methyl-2-pyrazinyl)-2-(4-(1,3,4-oxadiazol-2-yl)phenyl)-
  • N-(3-Methoxy-5-methylpyrazin-2-yl)-2-[4-(1,3,4-oxadiazol-2- yl)phenyl]pyridine-3-sulfonamide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
424.44 g/molcalc.
Exact mass
424.0954 Dacalc.
LogP (octanol/water)
2.71calc.
Topological polar surface area
133 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
9calc.
Rotatable bonds
6calc.
Heavy atoms
30calc.
Rings
4calc.
Aromatic rings
4calc.
Fraction sp3 carbons
0.11calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=S(=O)(Nc1cnccn1)c1cccnc1-c1ccc(-c2nnco2)cc1

O=S(=O)(Nc1cnccn1)c1cccnc1-c1ccc(-c2nnco2)cc1

4 rings, 27 atoms.

1 other chemical share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H302Harmful if swallowed.
  • H360May damage fertility or the unborn child.
  • H373May cause damage to organs through prolonged or repeated exposure.
  • H411Toxic to aquatic life with long lasting effects.
Precautionary statements (13)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P330Rinse mouth.
  • P391Collect spillage.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Zibotentan suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 9 suppliers
9 of 9 offers
  • Lonza Inc.
    United States, Morristown ManufacturerUnclaimed profile
    ZibotentanGrade, purity and minimum order on request
    Price on request
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  • Alomone Labs Ltd.
    Israel, JerusalemUnclaimed profile
    ZibotentanGrade, purity and minimum order on request
    Price on request
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  • Angel Pharmatech Ltd.
    China, ShanghaiUnclaimed profile
    ZibotentanGrade, purity and minimum order on request
    Price on request
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  • Glixx Labs, Inc
    United States, HopkintonUnclaimed profile
    ZibotentanGrade, purity and minimum order on request
    Price on request
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  • Pharmacore Co., Limited
    China, KunshanUnclaimed profile
    ZibotentanGrade, purity and minimum order on request
    Price on request
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  • Selleck Chemicals
    United States, HoustonUnclaimed profile
    ZibotentanGrade, purity and minimum order on request
    Price on request
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  • Sun-shine Chemical
    China, WuhanUnclaimed profile
    ZibotentanGrade, purity and minimum order on request
    Price on request
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  • Synblock Inc
    Canada, MontrealUnclaimed profile
    ZibotentanGrade, purity and minimum order on request
    Price on request
    View
  • Thoreauchem
    China, HongKongUnclaimed profile
    ZibotentanGrade, purity and minimum order on request
    Price on request
    View

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

9 suppliers in 4 countries

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Zibotentan price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antagonist
  • antihypertensive agent
  • antineoplastic agent
  • cardiovascular drug
  • endothelin A receptor antagonist
  • endothelin receptor antagonist
  • hepatoprotective agent
  • hormone antagonist
  • hormone receptor modulator
  • pharmaceutical
  • protective agent
  • receptor modulator

Pharmacology

Zibotentan is an orally available selective antagonist of the endothelin-A (ET-A) receptor with potential antineoplastic activity. Zibotentan binds selectively to the ET-A receptor, thereby inhibiting endothelin-mediated mechanisms that promote tumor cell proliferation.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Zibotentan is traded under.

HS 2935.90Indicative HS code

Sulphonamides, other

World exports in 2024
$5.64B
−11.0% vs 2023, imports $8.56B
2019 to 2024
Top exporters
  1. Ireland43.1%
  2. China12.0%
  3. India * partner reported9.5%
Top importers
  1. United States23.6%
  2. Slovenia19.1%
  3. Spain11.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Zibotentan is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Zibotentan, based on the data on this page

What is Zibotentan?

Zibotentan is a member of the class of pyridinesulfonamides that is benzene substituted by 3-[(3-methoxy-5-methylpyrazin-2-yl)sulfamoyl]pyridin-2-yl and 1,3,4-oxadiazol-2-yl groups at positions 1 and 4, respectively. It is an endothelin A receptor antagonist with potential antineoplastic activity.

What is the CAS number of Zibotentan?

The CAS registry number of Zibotentan is 186497-07-4.

What is the molecular formula and weight of Zibotentan?

The molecular formula of Zibotentan is C19H16N6O4S and its molar mass is 424.44 g/mol.

What is Zibotentan used for?

Known uses and roles of Zibotentan include building blocks in research and laboratory, screening compounds in research and laboratory, antagonist, antihypertensive agent, antineoplastic agent and 9 more.

Is Zibotentan hazardous?

Zibotentan carries the GHS signal word "Danger". Main hazards: harmful if swallowed, may damage fertility or the unborn child, may cause damage to organs through prolonged or repeated exposure. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Zibotentan?

Zibotentan is usually classified under HS code 293590 (Sulphonamides, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Zibotentan?

CompoundList lists 9 suppliers of Zibotentan in China, United States, Canada and Israel. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Zibotentan?

Suppliers quote Zibotentan on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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