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Central nervous system drugs

Ziprasidone

Also known as ziprasidona, Zipradon, ziprasidonum

CAS 146939-27-7Formula C21H21ClN4OSMolar mass 412.95 g/molEC 638-809-1
GHS signal word: Warning. Pictograms: Serious health hazard 75 suppliers listed Drug substance
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Ziprasidone chemical structure, C21H21ClN4OS, CAS 146939-27-7
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
146939-27-7
Formula
C21H21ClN4OS
Molar mass
412.95 g/mol
Flash point
-2 °C
HS code
293499
Category
Central nervous system drugs

What is Ziprasidone?

Plain description, key identifiers and synonyms

Ziprasidone is a piperazine compound having 1,2-benzothiazol-3-yl- and 2-(6-chloro-1,3-dihydro-2-oxindol-5-yl)ethyl substituents attached to the nitrogen atoms. It has a role as a psychotropic drug, an antipsychotic agent, a histamine antagonist, a serotonergic antagonist, a dopaminergic antagonist and a muscarinic antagonist. It is a member of indolones, a member of piperazines, an organochlorine compound and a 1,2-benzisothiazole.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
5-[2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl]-6-chloro-1,3-dihydroindol-2-one
CAS number
146939-27-7 CAS number cross-checked
EC numbers
638-809-1, 928-541-6
Molecular formula
C21H21ClN4OS
UNII
6UKA5VEJ6X
MDL number
MFCD00866661, MFCD06795476
InChIKey
MVWVFYHBGMAFLY-UHFFFAOYSA-N
InChI
InChI=1S/C21H21ClN4OS/c22-17-13-18-15(12-20(27)23-18)11-14(17)5-6-25-7-9-26(10-8-25)21-16-3-1-2-4-19(16)28-24-21/h1-4,11,13H,5-10,12H2,(H,23,27)
SMILES (canonical and isomeric)
C1CN(CCN1CCC2=C(C=C3C(=C2)CC(=O)N3)Cl)C4=NSC5=CC=CC=C54

Synonyms

  • ziprasidona
  • Zipradon
  • ziprasidonum
  • 5-[2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl]-6-chloro-1,3-dihydroindol-2-one
  • 2H-Indol-2-one, 5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-
  • 5-{2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl}-6-chloro-2,3-dihydro-1H-indol-2-one
  • ziprazidone
  • 2H-Indol-2-one, 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-
  • CP-88,059
  • 5-(2-(4-(1,2-benzothiazol-3-yl)piperazin-1-yl)ethyl)-6-chloro-1,3-dihydroindol-2-one
  • CP-88,059-01
  • 5-(2-(4-(1,2-benzothiazol-3-yl)piperazin-1-yl)ethyl)-6-chloro-2,3-dihydro-1H-indol-2-one
  • 5-(2-(4-(3-benzisothiazolyl)piperazinyl)ethyl)-6-chloro-1,3-dihydro-2H-indol-2-one
  • Geodon
  • CP 88059
  • Ziprasidone (INN)
  • C21H21ClN4OS
  • Ziprasidone free base
  • 5-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)ethyl)-6-chloroindolin-2-one
  • 5-{2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl}-6-chloro-1,3-dihydro-2H-indol-2-one
  • 5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one
  • Zipradon (TN)
  • Ziprasidone NX
  • 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-2h-indol-2-one
  • Ziprasidone Impurity 66
Show all 27 synonyms
  • 5-[2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl]-6-chloro-1,3-dihydroindol-2-one, hydrate, hydrochloride
  • Ziprasidone - Bio-X trade mark

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Flash point
-2 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
412.95 g/molcalc.
Exact mass
412.1125 Dacalc.
LogP (octanol/water)
3.81calc.
Topological polar surface area
48.47 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
4calc.
Heavy atoms
28calc.
Rings
5calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.33calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1Cc2cc(CCN3CCN(c4nsc5ccccc45)CC3)ccc2N1

O=C1Cc2cc(CCN3CCN(c4nsc5ccccc45)CC3)ccc2N1

5 rings, 27 atoms, the Ziprasidone impurity 10 ring system.

10 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H373May cause damage to organs through prolonged or repeated exposure.
Precautionary statements (3)
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P319Get medical help if you feel unwell.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Ziprasidone suppliers

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All 75 suppliers
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Where suppliers are based

75 suppliers in 15 countries

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Ziprasidone price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Antipsychotic Agents, Dopamine Antagonists, Serotonin Antagonists.

Industries and functions

Pharmacological actions

  • Antipsychotic Agents
  • Dopamine Antagonists
  • Serotonin Antagonists

Roles

  • antagonist
  • antidepressant
  • antipsychotic agent
  • anxiolytic drug
  • cardiovascular drug
  • central nervous system depressant
  • central nervous system drug
  • cholinergic antagonist
  • cholinergic drug
  • dopaminergic agent
  • dopaminergic antagonist
  • histamine antagonist
  • histaminergic drug
  • muscarinic antagonist
  • neurotransmitter agent
  • pharmaceutical
  • psychotropic drug
  • serotonergic antagonist
  • serotonergic drug
  • tranquilizing drug

Pharmacology

Ziprasidone is an Atypical Antipsychotic.

How it is made

Preparation: By refluxing 5-(2-chloroethyl)oxindole and N-(1,2-benzisothiazol-3-yl)piperazine with sodium carbonate and sodium iodide in methyl isobutyl ketone, followed by evaporation of the solvent and chromatography on silica gel with 4% methanol in methylene chloride. The salt is formed from the amine by addition of ether saturated with HCl gas.

Preparation: J. A. Lowe III, A. A. Nagel, European Patent Office patent 281309, eidem, United States of America patent 4831031 (1988, 1989 both to Pfizer).

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Ziprasidone is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Ziprasidone is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Ziprasidone, based on the data on this page

What is Ziprasidone?

Ziprasidone is a piperazine compound having 1,2-benzothiazol-3-yl- and 2-(6-chloro-1,3-dihydro-2-oxindol-5-yl)ethyl substituents attached to the nitrogen atoms.

What is the CAS number of Ziprasidone?

The CAS registry number of Ziprasidone is 146939-27-7.

What is the molecular formula and weight of Ziprasidone?

The molecular formula of Ziprasidone is C21H21ClN4OS and its molar mass is 412.95 g/mol.

What is Ziprasidone used for?

Antipsychotic Agents, Dopamine Antagonists, Serotonin Antagonists.

Is Ziprasidone hazardous?

Ziprasidone carries the GHS signal word "Warning". Main hazards: may cause damage to organs through prolonged or repeated exposure. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Ziprasidone?

Ziprasidone is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Ziprasidone?

CompoundList lists 75 suppliers of Ziprasidone in China, United States, India, United Kingdom and 11 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Ziprasidone in India?

6 suppliers in India list Ziprasidone on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Ziprasidone?

Suppliers quote Ziprasidone on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Ziprasidone

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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