CompoundList
Sign in
Murcko scaffold

Ring system with 4 rings and 24 atoms

37 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
24
Chemicals
37
With full pages
0
Scaffold SMILES

O=c1[nH]c2ccccc2n1C1CCN(CCc2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1[nH]c2ccccc2n1C1CCN(CCc2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 37 of 37 chemicals

Butanedioic acid--1-{1-[1-(3,4-dimethoxyphenyl)-1-hydroxypropan-2-yl]piperidin-4-yl}-1H-1,3-benzimidazol-2-ol (1/1) chemical structure, C27H35N3O8, CAS 85984-40-3
Butanedioic acid--1-{1-[1-(3,4-dimethoxyphenyl)-1-hydroxypropan-2-yl]piperidin-4-yl}-1H-1,3-benzimidazol-2-ol (1/1)
CAS 85984-40-3C27H35N3O8
KF 4307 chemical structure, C23H29N3O4, CAS 74178-99-7
KF 4307
CAS 74178-99-7C23H29N3O4
2H-Benzimidazol-2-one, 1,3-dihydro-1-(1-(2-(3,4-dihydroxyphenyl)-2-hydroxyethyl)-4-piperidinyl)- chemical structure, C20H23N3O4, CAS 74405-95-1
2H-Benzimidazol-2-one, 1,3-dihydro-1-(1-(2-(3,4-dihydroxyphenyl)-2-hydroxyethyl)-4-piperidinyl)-
CAS 74405-95-1C20H23N3O4
2H-Benzimidazol-2-one, 1,3-dihydro-1-(1-(2-(4-hydroxyphenyl)-2-hydroxyethyl)-4-piperidinyl)-,hydrochloride chemical structure, C20H23N3O3, CAS 74405-98-4
2H-Benzimidazol-2-one, 1,3-dihydro-1-(1-(2-(4-hydroxyphenyl)-2-hydroxyethyl)-4-piperidinyl)-,hydrochloride
CAS 74405-98-4C20H23N3O3
2H-Benzimidazol-2-one, 1,3-dihydro-1-(1-(2-(3,5-dihydroxyphenyl)-2-hydroxyethyl)-4-piperidinyl)-, hydrochloride chemical structure, C20H24ClN3O4, CAS 74405-99-5
2H-Benzimidazol-2-one, 1,3-dihydro-1-(1-(2-(3,5-dihydroxyphenyl)-2-hydroxyethyl)-4-piperidinyl)-, hydrochloride
CAS 74405-99-5C20H24ClN3O4
1-(1-(2-(3,5-Dihydroxyphenyl)-2-hydroxyethyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one chemical structure, C20H23N3O4, CAS 74406-11-4
1-(1-(2-(3,5-Dihydroxyphenyl)-2-hydroxyethyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
CAS 74406-11-4C20H23N3O4
2H-Benzimidazol-2-one, 1,3-dihydro-1-(1-(2-(4-hydroxy-3-(hydroxymethyl)phenyl)-2-hydroxyethyl)-4-piperidinyl)-, hydrochloride chemical structure, C21H26ClN3O4, CAS 74406-00-1
2H-Benzimidazol-2-one, 1,3-dihydro-1-(1-(2-(4-hydroxy-3-(hydroxymethyl)phenyl)-2-hydroxyethyl)-4-piperidinyl)-, hydrochloride
CAS 74406-00-1C21H26ClN3O4
Benzoic acid, 2-hydroxy-5-(1-hydroxy-2-(4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinyl)ethyl)-, methyl ester chemical structure, C22H25N3O5, CAS 74406-01-2
Benzoic acid, 2-hydroxy-5-(1-hydroxy-2-(4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinyl)ethyl)-, methyl ester
CAS 74406-01-2C22H25N3O5
Urea, N-(2-hydroxy-5-(1-hydroxy-2-(4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinyl)ethyl)phenyl)- chemical structure, C21H25N5O4, CAS 74406-02-3
Urea, N-(2-hydroxy-5-(1-hydroxy-2-(4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinyl)ethyl)phenyl)-
CAS 74406-02-3C21H25N5O4
Sulfamide, N-(2-hydroxy-5-(1-hydroxy-2-(4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinyl)ethyl)phenyl)-, hydrochloride chemical structure, C20H26ClN5O5S, CAS 74406-03-4
Sulfamide, N-(2-hydroxy-5-(1-hydroxy-2-(4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinyl)ethyl)phenyl)-, hydrochloride
CAS 74406-03-4C20H26ClN5O5S
Methanesulfonamide, N-(2-hydroxy-5-(1-hydroxy-2-(4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinyl)ethyl)phenyl)-, hydrochloride chemical structure, C21H27ClN4O5S, CAS 74406-04-5
Methanesulfonamide, N-(2-hydroxy-5-(1-hydroxy-2-(4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinyl)ethyl)phenyl)-, hydrochloride
CAS 74406-04-5C21H27ClN4O5S
Acetic acid, ((2-hydroxy-5-(1-hydroxy-2-(4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinyl)ethyl)phenyl)amino)oxo- chemical structure, C22H24N4O6, CAS 74406-05-6
Acetic acid, ((2-hydroxy-5-(1-hydroxy-2-(4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinyl)ethyl)phenyl)amino)oxo-
CAS 74406-05-6C22H24N4O6
Formamide, N-(2-hydroxy-5-(1-hydroxy-2-(4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinyl)ethyl)phenyl)-, hydrochloride chemical structure, C21H25ClN4O4, CAS 74406-06-7
Formamide, N-(2-hydroxy-5-(1-hydroxy-2-(4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinyl)ethyl)phenyl)-, hydrochloride
CAS 74406-06-7C21H25ClN4O4
2H-Benzimidazol-2-one, 1,3-dihydro-1-(1-(2-(3,4-dihydroxyphenyl)-2-hydroxyethyl)-4-piperidinyl)-3-methyl- chemical structure, C21H25N3O4, CAS 74406-07-8
2H-Benzimidazol-2-one, 1,3-dihydro-1-(1-(2-(3,4-dihydroxyphenyl)-2-hydroxyethyl)-4-piperidinyl)-3-methyl-
CAS 74406-07-8C21H25N3O4
KF 4942 chemical structure, C24H31N3O5, CAS 74179-08-1
KF 4942
CAS 74179-08-1C24H31N3O5
1-Acetyl-3-(1-phenethylpiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one chemical structure, C22H25N3O2, CAS 343614-45-9
1-Acetyl-3-(1-phenethylpiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
CAS 343614-45-9C22H25N3O2
1-(1-(2-Methyl-1-phenylpropan-2-yl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one chemical structure, C22H27N3O, CAS 231960-66-0
1-(1-(2-Methyl-1-phenylpropan-2-yl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
CAS 231960-66-0C22H27N3O
1-(1-(3,4-Dihydroxyphenethyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one chemical structure, C20H23N3O3, CAS 752934-20-6
1-(1-(3,4-Dihydroxyphenethyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
CAS 752934-20-6C20H23N3O3
1-(1-(1-Hydroxy-1-(3-hydroxyphenyl)propan-2-yl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one chemical structure, C21H25N3O3, CAS 789440-34-2
1-(1-(1-Hydroxy-1-(3-hydroxyphenyl)propan-2-yl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
CAS 789440-34-2C21H25N3O3
1-[2-Hydroxy-2-phenyl-1-ethyl]-4-(2-keto-1-benzimidazolinyl)-piperidine chemical structure, C20H23N3O2, CAS 74179-02-5
1-[2-Hydroxy-2-phenyl-1-ethyl]-4-(2-keto-1-benzimidazolinyl)-piperidine
CAS 74179-02-5C20H23N3O2
1-(1-(3,4-Diaminophenethyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one chemical structure, C20H25N5O, CAS 756798-81-9
1-(1-(3,4-Diaminophenethyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
CAS 756798-81-9C20H25N5O
1-(1-(4-Nitrophenethyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one chemical structure, C20H22N4O3, CAS 1389642-84-5
1-(1-(4-Nitrophenethyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
CAS 1389642-84-5C20H22N4O3
1-(1-(2-(4-Fluorophenyl)-2-hydroxyethyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one chemical structure, C20H22FN3O2, CAS 2060777-39-9
1-(1-(2-(4-Fluorophenyl)-2-hydroxyethyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
CAS 2060777-39-9C20H22FN3O2
1-(1-(2-(4-Fluorophenyl)propyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one chemical structure, C21H24FN3O, CAS 47480-82-0
1-(1-(2-(4-Fluorophenyl)propyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
CAS 47480-82-0C21H24FN3O