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Murcko scaffold

Ring system with 3 rings and 18 atoms

10 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
10
With full pages
1
Scaffold SMILES

O=C(C1CC1)N1CCN(Cc2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(C1CC1)N1CCN(Cc2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 10 of 10 chemicals

(4-Benzylpiperazin-1-yl)-[3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropyl]methanone chemical structure, C19H24Cl2N2O, CAS 617694-01-6
(4-Benzylpiperazin-1-yl)-[3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropyl]methanone
CAS 617694-01-6C19H24Cl2N2O
(2,2-Dichloro-1-methylcyclopropyl)-[4-[(3-methoxyphenyl)methyl]piperazin-1-yl]methanone chemical structure, C17H22Cl2N2O2, CAS 895942-35-5
(2,2-Dichloro-1-methylcyclopropyl)-[4-[(3-methoxyphenyl)methyl]piperazin-1-yl]methanone
CAS 895942-35-5C17H22Cl2N2O2
[4-[(2-Chlorophenyl)methyl]piperazin-1-yl]-(2,2-dichloro-1-methylcyclopropyl)methanone chemical structure, C16H19Cl3N2O, CAS 895951-55-0
[4-[(2-Chlorophenyl)methyl]piperazin-1-yl]-(2,2-dichloro-1-methylcyclopropyl)methanone
CAS 895951-55-0C16H19Cl3N2O
3-[(4-Benzylpiperazin-1-yl)carbonyl]-2,2-dimethylcyclopropanecarboxylic acid chemical structure, C18H24N2O3, CAS 1142214-95-6
3-[(4-Benzylpiperazin-1-yl)carbonyl]-2,2-dimethylcyclopropanecarboxylic acid
CAS 1142214-95-6C18H24N2O3
3-[[4-(Cyclopropanecarbonyl)piperazin-1-yl]methyl]benzonitrile chemical structure, C16H19N3O, CAS 918482-06-1
3-[[4-(Cyclopropanecarbonyl)piperazin-1-yl]methyl]benzonitrile
CAS 918482-06-1C16H19N3O
Cyclopropyl{4-[(2,6-dimethylphenyl)methyl]piperazin-1-yl}methanone chemical structure, C17H24N2O, CAS 918482-03-8
Cyclopropyl{4-[(2,6-dimethylphenyl)methyl]piperazin-1-yl}methanone
CAS 918482-03-8C17H24N2O
1-Cyclopropanecarbonyl-4-{[4-(trifluoromethyl)phenyl]methyl}piperazine chemical structure, C16H19F3N2O, CAS 439848-06-3
1-Cyclopropanecarbonyl-4-{[4-(trifluoromethyl)phenyl]methyl}piperazine
CAS 439848-06-3C16H19F3N2O
1-Cyclopropanecarbonyl-4-[(3,5-dimethoxyphenyl)methyl]piperazine chemical structure, C17H24N2O3, CAS 2325362-34-1
1-Cyclopropanecarbonyl-4-[(3,5-dimethoxyphenyl)methyl]piperazine
CAS 2325362-34-1C17H24N2O3
{4-[(4-Chlorophenyl)methyl]piperazin-1-yl}(2,2-dichlorocyclopropyl)methanone chemical structure, C15H17Cl3N2O, CAS 1993318-27-6
{4-[(4-Chlorophenyl)methyl]piperazin-1-yl}(2,2-dichlorocyclopropyl)methanone
CAS 1993318-27-6C15H17Cl3N2O
[4-[(3-Bromophenyl)methyl]piperazin-1-yl]-cyclopropylmethanone chemical structure, C15H19BrN2O, CAS 2329296-76-4
[4-[(3-Bromophenyl)methyl]piperazin-1-yl]-cyclopropylmethanone
CAS 2329296-76-4C15H19BrN2O