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Murcko scaffold

Ring system with 3 rings and 26 atoms

16 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
26
Chemicals
16
With full pages
1
Scaffold SMILES

O=C1CC(C(=O)Nc2ccccc2)SC(=NNC(=O)c2ccccc2)N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1CC(C(=O)Nc2ccccc2)SC(=NNC(=O)c2ccccc2)N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 16 of 16 chemicals

2-[(2-Chlorobenzoyl)hydrazinylidene]-4-oxo-N-phenyl-1,3-thiazinane-6-carboxamide chemical structure, C18H15ClN4O3S
2-[(2-Chlorobenzoyl)hydrazinylidene]-4-oxo-N-phenyl-1,3-thiazinane-6-carboxamide
C18H15ClN4O3S
2-(2-(2,4-Dichlorobenzoyl)hydrazinyl)-4-oxo-N-(o-tolyl)-5,6-dihydro-4H-1,3-thiazine-6-carboxamide chemical structure, C19H16Cl2N4O3S, CAS 577696-63-0
2-(2-(2,4-Dichlorobenzoyl)hydrazinyl)-4-oxo-N-(o-tolyl)-5,6-dihydro-4H-1,3-thiazine-6-carboxamide
CAS 577696-63-0C19H16Cl2N4O3S
N-(3-Methoxyphenyl)-2-(2-(4-methylbenzoyl)hydrazinyl)-4-oxo-5,6-dihydro-4H-1,3-thiazine-6-carboxamide chemical structure, C20H20N4O4S, CAS 689753-38-6
N-(3-Methoxyphenyl)-2-(2-(4-methylbenzoyl)hydrazinyl)-4-oxo-5,6-dihydro-4H-1,3-thiazine-6-carboxamide
CAS 689753-38-6C20H20N4O4S
N-(4-Methylphenyl)(2-{[(4-methylphenyl)carbonylamino]amino}-4-oxo(5,6-dihydro-1,3-thiazin-6-yl))carboxamide chemical structure, C20H20N4O3S, CAS 689753-21-7
N-(4-Methylphenyl)(2-{[(4-methylphenyl)carbonylamino]amino}-4-oxo(5,6-dihydro-1,3-thiazin-6-yl))carboxamide
CAS 689753-21-7C20H20N4O3S
2-[(2-Chlorobenzoyl)hydrazinylidene]-4-oxo-N-phenyl-1,3-thiazinane-6-carboxamide chemical structure, C18H15ClN4O3S, CAS 573971-85-4
2-[(2-Chlorobenzoyl)hydrazinylidene]-4-oxo-N-phenyl-1,3-thiazinane-6-carboxamide
CAS 573971-85-4C18H15ClN4O3S
2-[(2-Methoxybenzoyl)hydrazinylidene]-4-oxo-N-phenyl-1,3-thiazinane-6-carboxamide chemical structure, C19H18N4O4S
2-[(2-Methoxybenzoyl)hydrazinylidene]-4-oxo-N-phenyl-1,3-thiazinane-6-carboxamide
C19H18N4O4S
2-[(2,4-Dichlorobenzoyl)hydrazinylidene]-N-(4-ethoxyphenyl)-4-oxo-1,3-thiazinane-6-carboxamide chemical structure, C20H18Cl2N4O4S, CAS 578720-28-2
2-[(2,4-Dichlorobenzoyl)hydrazinylidene]-N-(4-ethoxyphenyl)-4-oxo-1,3-thiazinane-6-carboxamide
CAS 578720-28-2C20H18Cl2N4O4S
N-(3-Methoxyphenyl)-2-[(4-methylbenzoyl)hydrazinylidene]-4-oxo-1,3-thiazinane-6-carboxamide chemical structure, C20H20N4O4S
N-(3-Methoxyphenyl)-2-[(4-methylbenzoyl)hydrazinylidene]-4-oxo-1,3-thiazinane-6-carboxamide
C20H20N4O4S
2-[(2,4-Dichlorobenzoyl)hydrazinylidene]-N-(4-ethoxyphenyl)-4-oxo-1,3-thiazinane-6-carboxamide chemical structure, C20H18Cl2N4O4S
2-[(2,4-Dichlorobenzoyl)hydrazinylidene]-N-(4-ethoxyphenyl)-4-oxo-1,3-thiazinane-6-carboxamide
C20H18Cl2N4O4S
2-[(4-Methylbenzoyl)hydrazinylidene]-4-oxo-N-phenyl-1,3-thiazinane-6-carboxamide chemical structure, C19H18N4O3S
2-[(4-Methylbenzoyl)hydrazinylidene]-4-oxo-N-phenyl-1,3-thiazinane-6-carboxamide
C19H18N4O3S
2-[(4-Chlorobenzoyl)hydrazinylidene]-N-(4-methoxyphenyl)-4-oxo-1,3-thiazinane-6-carboxamide chemical structure, C19H17ClN4O4S, CAS 573708-83-5
2-[(4-Chlorobenzoyl)hydrazinylidene]-N-(4-methoxyphenyl)-4-oxo-1,3-thiazinane-6-carboxamide
CAS 573708-83-5C19H17ClN4O4S
2-[(2,4-Dichlorobenzoyl)hydrazinylidene]-N-(2-methylphenyl)-4-oxo-1,3-thiazinane-6-carboxamide chemical structure, C19H16Cl2N4O3S
2-[(2,4-Dichlorobenzoyl)hydrazinylidene]-N-(2-methylphenyl)-4-oxo-1,3-thiazinane-6-carboxamide
C19H16Cl2N4O3S
2-[(4-Chlorobenzoyl)hydrazinylidene]-N-(4-methoxyphenyl)-4-oxo-1,3-thiazinane-6-carboxamide chemical structure, C19H17ClN4O4S
2-[(4-Chlorobenzoyl)hydrazinylidene]-N-(4-methoxyphenyl)-4-oxo-1,3-thiazinane-6-carboxamide
C19H17ClN4O4S
2-{2-[(2-Methoxyphenyl)carbonyl]hydrazinyl}-4-oxo-N-phenyl-5,6-dihydro-4H-1,3-thiazine-6-carboxamide chemical structure, C19H18N4O4S, CAS 579441-09-1
2-{2-[(2-Methoxyphenyl)carbonyl]hydrazinyl}-4-oxo-N-phenyl-5,6-dihydro-4H-1,3-thiazine-6-carboxamide
CAS 579441-09-1C19H18N4O4S
N-(4-Methylphenyl)-2-[[(4-methylphenyl)-oxomethyl]hydrazo]-4-oxo-5,6-dihydro-1,3-thiazine-6-carboxamide chemical structure, C20H20N4O3S
N-(4-Methylphenyl)-2-[[(4-methylphenyl)-oxomethyl]hydrazo]-4-oxo-5,6-dihydro-1,3-thiazine-6-carboxamide
C20H20N4O3S
2-(2-(4-Methylbenzoyl)hydrazinyl)-4-oxo-N-phenyl-5,6-dihydro-4H-1,3-thiazine-6-carboxamide chemical structure, C19H18N4O3S, CAS 577963-23-6
2-(2-(4-Methylbenzoyl)hydrazinyl)-4-oxo-N-phenyl-5,6-dihydro-4H-1,3-thiazine-6-carboxamide
CAS 577963-23-6C19H18N4O3S