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Murcko scaffold

Ring system with 4 rings and 26 atoms

105 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
26
Chemicals
105
With full pages
1
Scaffold SMILES

O=C(NCC1CCCO1)c1cc2ccccc2oc1=Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(NCC1CCCO1)c1cc2ccccc2oc1=Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 105 chemicals

(2Z)-2-[(4-Fluorophenyl)imino]-N-(tetrahydrofuran-2-ylmethyl)-2H-chromene-3-carboxamide chemical structure, C21H19FN2O3, CAS 478481-19-5
(2Z)-2-[(4-Fluorophenyl)imino]-N-(tetrahydrofuran-2-ylmethyl)-2H-chromene-3-carboxamide
CAS 478481-19-5C21H19FN2O3
(2Z)-2-[(3-Methoxyphenyl)imino]-N-(tetrahydrofuran-2-ylmethyl)-2H-chromene-3-carboxamide chemical structure, C22H22N2O4, CAS 478481-21-9
(2Z)-2-[(3-Methoxyphenyl)imino]-N-(tetrahydrofuran-2-ylmethyl)-2H-chromene-3-carboxamide
CAS 478481-21-9C22H22N2O4
(2Z)-2-[(2-Ethoxyphenyl)imino]-N-(tetrahydrofuran-2-ylmethyl)-2H-chromene-3-carboxamide chemical structure, C23H24N2O4, CAS 478481-26-4
(2Z)-2-[(2-Ethoxyphenyl)imino]-N-(tetrahydrofuran-2-ylmethyl)-2H-chromene-3-carboxamide
CAS 478481-26-4C23H24N2O4
(2Z)-8-Methoxy-2-[(2-methylphenyl)imino]-N-(tetrahydrofuran-2-ylmethyl)-2H-chromene-3-carboxamide chemical structure, C23H24N2O4, CAS 478481-46-8
(2Z)-8-Methoxy-2-[(2-methylphenyl)imino]-N-(tetrahydrofuran-2-ylmethyl)-2H-chromene-3-carboxamide
CAS 478481-46-8C23H24N2O4
(2Z)-8-Methoxy-2-[(2-methoxyphenyl)imino]-N-(tetrahydrofuran-2-ylmethyl)-2H-chromene-3-carboxamide chemical structure, C23H24N2O5, CAS 478481-48-0
(2Z)-8-Methoxy-2-[(2-methoxyphenyl)imino]-N-(tetrahydrofuran-2-ylmethyl)-2H-chromene-3-carboxamide
CAS 478481-48-0C23H24N2O5
(2Z)-8-Methoxy-2-[(4-methoxyphenyl)imino]-N-(tetrahydrofuran-2-ylmethyl)-2H-chromene-3-carboxamide chemical structure, C23H24N2O5, CAS 478481-50-4
(2Z)-8-Methoxy-2-[(4-methoxyphenyl)imino]-N-(tetrahydrofuran-2-ylmethyl)-2H-chromene-3-carboxamide
CAS 478481-50-4C23H24N2O5
2-(2,4-Dimethoxyphenyl)imino-8-methoxy-N-(oxolan-2-ylmethyl)chromene-3-carboxamide chemical structure, C24H26N2O6, CAS 478481-51-5
2-(2,4-Dimethoxyphenyl)imino-8-methoxy-N-(oxolan-2-ylmethyl)chromene-3-carboxamide
CAS 478481-51-5C24H26N2O6
(2Z)-6-Bromo-2-[(2-methoxyphenyl)imino]-N-(tetrahydrofuran-2-ylmethyl)-2H-chromene-3-carboxamide chemical structure, C22H21BrN2O4, CAS 478481-66-2
(2Z)-6-Bromo-2-[(2-methoxyphenyl)imino]-N-(tetrahydrofuran-2-ylmethyl)-2H-chromene-3-carboxamide
CAS 478481-66-2C22H21BrN2O4
(2Z)-6-Bromo-2-(phenylimino)-N-(tetrahydrofuran-2-ylmethyl)-2H-chromene-3-carboxamide chemical structure, C21H19BrN2O3, CAS 1327194-77-3
(2Z)-6-Bromo-2-(phenylimino)-N-(tetrahydrofuran-2-ylmethyl)-2H-chromene-3-carboxamide
CAS 1327194-77-3C21H19BrN2O3
(2Z)-6-Bromo-2-[(4-carbamoylphenyl)imino]-N-(tetrahydrofuran-2-ylmethyl)-2H-chromene-3-carboxamide chemical structure, C22H20BrN3O4, CAS 1327175-90-5
(2Z)-6-Bromo-2-[(4-carbamoylphenyl)imino]-N-(tetrahydrofuran-2-ylmethyl)-2H-chromene-3-carboxamide
CAS 1327175-90-5C22H20BrN3O4
Methyl 3-{[(2Z)-6-bromo-3-{[(oxolan-2-yl)methyl]carbamoyl}-2H-chromen-2-ylidene]amino}benzoate chemical structure, C23H21BrN2O5, CAS 1327184-29-1
Methyl 3-{[(2Z)-6-bromo-3-{[(oxolan-2-yl)methyl]carbamoyl}-2H-chromen-2-ylidene]amino}benzoate
CAS 1327184-29-1C23H21BrN2O5
Ethyl 3-({(2Z)-6-bromo-3-[(tetrahydrofuran-2-ylmethyl)carbamoyl]-2H-chromen-2-ylidene}amino)benzoate chemical structure, C24H23BrN2O5, CAS 1327169-22-1
Ethyl 3-({(2Z)-6-bromo-3-[(tetrahydrofuran-2-ylmethyl)carbamoyl]-2H-chromen-2-ylidene}amino)benzoate
CAS 1327169-22-1C24H23BrN2O5
Methyl 4-({(2Z)-6-bromo-3-[(tetrahydrofuran-2-ylmethyl)carbamoyl]-2H-chromen-2-ylidene}amino)benzoate chemical structure, C23H21BrN2O5, CAS 1327168-54-6
Methyl 4-({(2Z)-6-bromo-3-[(tetrahydrofuran-2-ylmethyl)carbamoyl]-2H-chromen-2-ylidene}amino)benzoate
CAS 1327168-54-6C23H21BrN2O5
Ethyl 4-({(2Z)-6-bromo-3-[(tetrahydrofuran-2-ylmethyl)carbamoyl]-2H-chromen-2-ylidene}amino)benzoate chemical structure, C24H23BrN2O5, CAS 1327169-68-5
Ethyl 4-({(2Z)-6-bromo-3-[(tetrahydrofuran-2-ylmethyl)carbamoyl]-2H-chromen-2-ylidene}amino)benzoate
CAS 1327169-68-5C24H23BrN2O5
(2Z)-6-Bromo-2-[(2,4-difluorophenyl)imino]-N-(tetrahydrofuran-2-ylmethyl)-2H-chromene-3-carboxamide chemical structure, C21H17BrF2N2O3, CAS 1327180-06-2
(2Z)-6-Bromo-2-[(2,4-difluorophenyl)imino]-N-(tetrahydrofuran-2-ylmethyl)-2H-chromene-3-carboxamide
CAS 1327180-06-2C21H17BrF2N2O3
(2Z)-6-Bromo-2-[(2,5-difluorophenyl)imino]-N-(tetrahydrofuran-2-ylmethyl)-2H-chromene-3-carboxamide chemical structure, C21H17BrF2N2O3, CAS 1327180-36-8
(2Z)-6-Bromo-2-[(2,5-difluorophenyl)imino]-N-(tetrahydrofuran-2-ylmethyl)-2H-chromene-3-carboxamide
CAS 1327180-36-8C21H17BrF2N2O3
(2Z)-6-Bromo-2-[(3,4-difluorophenyl)imino]-N-[(oxolan-2-yl)methyl]-2H-chromene-3-carboxamide chemical structure, C21H17BrF2N2O3, CAS 1327185-39-6
(2Z)-6-Bromo-2-[(3,4-difluorophenyl)imino]-N-[(oxolan-2-yl)methyl]-2H-chromene-3-carboxamide
CAS 1327185-39-6C21H17BrF2N2O3
(2Z)-6-Bromo-2-[(3,5-difluorophenyl)imino]-N-(tetrahydrofuran-2-ylmethyl)-2H-chromene-3-carboxamide chemical structure, C21H17BrF2N2O3, CAS 1327194-65-9
(2Z)-6-Bromo-2-[(3,5-difluorophenyl)imino]-N-(tetrahydrofuran-2-ylmethyl)-2H-chromene-3-carboxamide
CAS 1327194-65-9C21H17BrF2N2O3
(2Z)-6-Bromo-2-[(2-chlorophenyl)imino]-N-(tetrahydrofuran-2-ylmethyl)-2H-chromene-3-carboxamide chemical structure, C21H18BrClN2O3, CAS 1327175-91-6
(2Z)-6-Bromo-2-[(2-chlorophenyl)imino]-N-(tetrahydrofuran-2-ylmethyl)-2H-chromene-3-carboxamide
CAS 1327175-91-6C21H18BrClN2O3
(2Z)-6-Bromo-2-[(3-chlorophenyl)imino]-N-(tetrahydrofuran-2-ylmethyl)-2H-chromene-3-carboxamide chemical structure, C21H18BrClN2O3, CAS 1327179-41-8
(2Z)-6-Bromo-2-[(3-chlorophenyl)imino]-N-(tetrahydrofuran-2-ylmethyl)-2H-chromene-3-carboxamide
CAS 1327179-41-8C21H18BrClN2O3
(2Z)-6-Bromo-2-[(4-chlorophenyl)imino]-N-(tetrahydrofuran-2-ylmethyl)-2H-chromene-3-carboxamide chemical structure, C21H18BrClN2O3, CAS 1327168-59-1
(2Z)-6-Bromo-2-[(4-chlorophenyl)imino]-N-(tetrahydrofuran-2-ylmethyl)-2H-chromene-3-carboxamide
CAS 1327168-59-1C21H18BrClN2O3
(2Z)-6-Bromo-2-[(2-chloro-4-fluorophenyl)imino]-N-(tetrahydrofuran-2-ylmethyl)-2H-chromene-3-carboxamide chemical structure, C21H17BrClFN2O3, CAS 1327179-84-9
(2Z)-6-Bromo-2-[(2-chloro-4-fluorophenyl)imino]-N-(tetrahydrofuran-2-ylmethyl)-2H-chromene-3-carboxamide
CAS 1327179-84-9C21H17BrClFN2O3
(2Z)-6-Bromo-2-[(2-chloro-5-fluorophenyl)imino]-N-(tetrahydrofuran-2-ylmethyl)-2H-chromene-3-carboxamide chemical structure, C21H17BrClFN2O3, CAS 1327179-01-0
(2Z)-6-Bromo-2-[(2-chloro-5-fluorophenyl)imino]-N-(tetrahydrofuran-2-ylmethyl)-2H-chromene-3-carboxamide
CAS 1327179-01-0C21H17BrClFN2O3
(2Z)-6-Bromo-2-[(3-chloro-4-fluorophenyl)imino]-N-[(oxolan-2-yl)methyl]-2H-chromene-3-carboxamide chemical structure, C21H17BrClFN2O3, CAS 1327194-69-3
(2Z)-6-Bromo-2-[(3-chloro-4-fluorophenyl)imino]-N-[(oxolan-2-yl)methyl]-2H-chromene-3-carboxamide
CAS 1327194-69-3C21H17BrClFN2O3