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Murcko scaffold

Ring system with 4 rings and 21 atoms

13 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 21
Chemicals: 13
With full pages: 5

Scaffold SMILES

O=C1c2ccccc2CCC1C1C(=O)Nc2ccccc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C1c2ccccc2CCC1C1C(=O)Nc2ccccc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 13 of 13 chemicals

3-Hydroxy-3-(1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)-1,3-dihydro-2H-indol-2-one chemical structure, C18H15NO3, CAS 19579-63-6

3-Hydroxy-3-(1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)-1,3-dihydro-2H-indol-2-one

CAS 19579-63-6C₁₈H₁₅NO₃

5-Bromo-3-hydroxy-3-(1-oxo-3,4-dihydro-2H-naphthalen-2-yl)-1H-indol-2-one chemical structure, C18H14BrNO3, CAS 19579-65-8

5-Bromo-3-hydroxy-3-(1-oxo-3,4-dihydro-2H-naphthalen-2-yl)-1H-indol-2-one

CAS 19579-65-8C₁₈H₁₄BrNO₃

RefChem:381324 chemical structure, C20H19NO4, CAS 5711-42-2

CAS 5711-42-2C₂₀H₁₉NO₄

3-Hydroxy-3-(7-methoxy-1-oxo-3,4-dihydro-2H-naphthalen-2-yl)-1-methylindol-2-one chemical structure, C20H19NO4, CAS 312320-31-3

3-Hydroxy-3-(7-methoxy-1-oxo-3,4-dihydro-2H-naphthalen-2-yl)-1-methylindol-2-one

CAS 312320-31-3C₂₀H₁₉NO₄

3-Hydroxy-1-methyl-3-(1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)-1,3-dihydro-2H-indol-2-one chemical structure, C19H17NO3, CAS 346612-75-7

3-Hydroxy-1-methyl-3-(1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)-1,3-dihydro-2H-indol-2-one

CAS 346612-75-7C₁₉H₁₇NO₃

5-Bromo-3-hydroxy-3-(1-oxo-3,4-dihydro-2H-naphthalen-2-yl)-1-prop-2-enylindol-2-one chemical structure, C21H18BrNO3, CAS 717835-61-5

5-Bromo-3-hydroxy-3-(1-oxo-3,4-dihydro-2H-naphthalen-2-yl)-1-prop-2-enylindol-2-one

CAS 717835-61-5C₂₁H₁₈BrNO₃

3-Hydroxy-3-(1-oxo-3,4-dihydro-2H-naphthalen-2-yl)-1-propylindol-2-one chemical structure, C21H21NO3, CAS 717836-04-9

3-Hydroxy-3-(1-oxo-3,4-dihydro-2H-naphthalen-2-yl)-1-propylindol-2-one

CAS 717836-04-9C₂₁H₂₁NO₃

Ethyl [3-hydroxy-2-oxo-3-(1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)-2,3-dihydro-1H-indol-1-yl]acetate chemical structure, C22H21NO5, CAS 717836-12-9

Ethyl [3-hydroxy-2-oxo-3-(1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)-2,3-dihydro-1H-indol-1-yl]acetate

CAS 717836-12-9C₂₂H₂₁NO₅

2-[3-Hydroxy-2-oxo-3-(1-oxo-3,4-dihydro-2H-naphthalen-2-yl)indol-1-yl]acetamide chemical structure, C20H18N2O4, CAS 717836-67-4

2-[3-Hydroxy-2-oxo-3-(1-oxo-3,4-dihydro-2H-naphthalen-2-yl)indol-1-yl]acetamide

CAS 717836-67-4C₂₀H₁₈N₂O₄

5-Bromo-3-hydroxy-1-methyl-3-(1-oxo-1,2,3,4-tetrahydro-2-naphthalenyl)-1,3-dihydro-2H-indol-2-one chemical structure, C19H16BrNO3, CAS 839688-71-0

5-Bromo-3-hydroxy-1-methyl-3-(1-oxo-1,2,3,4-tetrahydro-2-naphthalenyl)-1,3-dihydro-2H-indol-2-one

CAS 839688-71-0C₁₉H₁₆BrNO₃

5-Chloro-3-hydroxy-3-(1-oxo-3,4-dihydro-2H-naphthalen-2-yl)-1H-indol-2-one chemical structure, C18H14ClNO3, CAS 839691-92-8

5-Chloro-3-hydroxy-3-(1-oxo-3,4-dihydro-2H-naphthalen-2-yl)-1H-indol-2-one

CAS 839691-92-8C₁₈H₁₄ClNO₃

5-Bromo-3-hydroxy-3-(1-oxo-3,4-dihydro-2H-naphthalen-2-yl)-1-propylindol-2-one chemical structure, C21H20BrNO3, CAS 878985-37-6

5-Bromo-3-hydroxy-3-(1-oxo-3,4-dihydro-2H-naphthalen-2-yl)-1-propylindol-2-one

CAS 878985-37-6C₂₁H₂₀BrNO₃

5-Bromo-1-butyl-3-hydroxy-3-(1-oxo-1,2,3,4-tetrahydro-2-naphthalenyl)-1,3-dihydro-2H-indol-2-one chemical structure, C22H22BrNO3, CAS 878987-50-9

5-Bromo-1-butyl-3-hydroxy-3-(1-oxo-1,2,3,4-tetrahydro-2-naphthalenyl)-1,3-dihydro-2H-indol-2-one

CAS 878987-50-9C₂₂H₂₂BrNO₃