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Murcko scaffold

3-[2-Oxo-2-(4-phenylpiperazin-1-yl)ethyl]quinazolin-4-one scaffold

13 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
26
Chemicals
13
With full pages
1
Scaffold SMILES

O=C(Cn1cnc2ccccc2c1=O)N1CCN(c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 3-[2-Oxo-2-(4-phenylpiperazin-1-yl)ethyl]quinazolin-4-one page
Murcko scaffold O=C(Cn1cnc2ccccc2c1=O)N1CCN(c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 13 of 13 chemicals

3-[2-Oxo-2-(4-phenylpiperazin-1-yl)ethyl]quinazolin-4-one chemical structure, C20H20N4O2, CAS 362494-42-6
3-[2-Oxo-2-(4-phenylpiperazin-1-yl)ethyl]quinazolin-4-one
CAS 362494-42-6C20H20N4O2
3-{2-[4-(3-Methoxyphenyl)-1-piperazinyl]-2-oxoethyl}-4(3H)-quinazolinone chemical structure, C21H22N4O3, CAS 362494-41-5
3-{2-[4-(3-Methoxyphenyl)-1-piperazinyl]-2-oxoethyl}-4(3H)-quinazolinone
CAS 362494-41-5C21H22N4O3
3-{1-[(4-Phenylpiperazino)carbonyl]propyl}-4(3H)-quinazolinone chemical structure, C22H24N4O2, CAS 900890-69-9
3-{1-[(4-Phenylpiperazino)carbonyl]propyl}-4(3H)-quinazolinone
CAS 900890-69-9C22H24N4O2
3-{2-[4-(2,3-Dimethylphenyl)piperazino]-2-oxoethyl}-4(3H)-quinazolinone chemical structure, C22H24N4O2, CAS 879569-02-5
3-{2-[4-(2,3-Dimethylphenyl)piperazino]-2-oxoethyl}-4(3H)-quinazolinone
CAS 879569-02-5C22H24N4O2
3-(1-{[4-(4-Fluorophenyl)piperazino]carbonyl}propyl)-4(3H)-quinazolinone chemical structure, C22H23FN4O2, CAS 900877-14-7
3-(1-{[4-(4-Fluorophenyl)piperazino]carbonyl}propyl)-4(3H)-quinazolinone
CAS 900877-14-7C22H23FN4O2
3-{2-[4-(4-Methoxyphenyl)-1-piperazinyl]-2-oxoethyl}-4(3H)-quinazolinone chemical structure, C21H22N4O3, CAS 903861-13-2
3-{2-[4-(4-Methoxyphenyl)-1-piperazinyl]-2-oxoethyl}-4(3H)-quinazolinone
CAS 903861-13-2C21H22N4O3
3-{2-[4-(4-Fluorophenyl)piperazin-1-yl]-2-oxoethyl}-6,7-dimethoxyquinazolin-4(3H)-one chemical structure, C22H23FN4O4, CAS 1081129-91-0
3-{2-[4-(4-Fluorophenyl)piperazin-1-yl]-2-oxoethyl}-6,7-dimethoxyquinazolin-4(3H)-one
CAS 1081129-91-0C22H23FN4O4
6,7-Dimethoxy-3-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]quinazolin-4(3H)-one chemical structure, C22H24N4O4, CAS 1081130-00-8
6,7-Dimethoxy-3-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]quinazolin-4(3H)-one
CAS 1081130-00-8C22H24N4O4
3-{2-[4-(2-Fluorophenyl)piperazin-1-yl]-2-oxoethyl}-6,7-dimethoxyquinazolin-4(3H)-one chemical structure, C22H23FN4O4, CAS 1081131-00-1
3-{2-[4-(2-Fluorophenyl)piperazin-1-yl]-2-oxoethyl}-6,7-dimethoxyquinazolin-4(3H)-one
CAS 1081131-00-1C22H23FN4O4
3-{2-[4-(3-Chlorophenyl)piperazin-1-yl]-2-oxoethyl}-6,7-dimethoxyquinazolin-4(3H)-one chemical structure, C22H23ClN4O4, CAS 1081141-74-3
3-{2-[4-(3-Chlorophenyl)piperazin-1-yl]-2-oxoethyl}-6,7-dimethoxyquinazolin-4(3H)-one
CAS 1081141-74-3C22H23ClN4O4
6,7-Dimethoxy-3-{2-[4-(3-methoxyphenyl)piperazin-1-yl]-2-oxoethyl}quinazolin-4(3H)-one chemical structure, C23H26N4O5, CAS 1081147-50-3
6,7-Dimethoxy-3-{2-[4-(3-methoxyphenyl)piperazin-1-yl]-2-oxoethyl}quinazolin-4(3H)-one
CAS 1081147-50-3C23H26N4O5
3-{2-[4-(3,4-Dichlorophenyl)piperazino]-2-oxoethyl}-4(3H)-quinazolinone chemical structure, C20H18Cl2N4O2, CAS 1144487-43-3
3-{2-[4-(3,4-Dichlorophenyl)piperazino]-2-oxoethyl}-4(3H)-quinazolinone
CAS 1144487-43-3C20H18Cl2N4O2
3-{2-[4-(2,4-Dimethylphenyl)piperazino]-2-oxoethyl}-4(3H)-quinazolinone chemical structure, C22H24N4O2, CAS 1144488-75-4
3-{2-[4-(2,4-Dimethylphenyl)piperazino]-2-oxoethyl}-4(3H)-quinazolinone
CAS 1144488-75-4C22H24N4O2