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Murcko scaffold

3-[2-Oxo-2-(4-phenylpiperazin-1-yl)ethyl]-2-sulfanylidene-1H-quinazolin-4-one scaffold

12 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 27
Chemicals: 12
With full pages: 2

Scaffold SMILES

O=C(Cn1c(=S)[nH]c2ccccc2c1=O)N1CCN(c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold Open the 3-[2-Oxo-2-(4-phenylpiperazin-1-yl)ethyl]-2-sulfanylidene-1H-quinazolin-4-one page

Murcko scaffold O=C(Cn1c(=S)[nH]c2ccccc2c1=O)N1CCN(c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 12 of 12 chemicals

3-[2-[4-(3-Chlorophenyl)piperazin-1-yl]-2-oxoethyl]-2-sulfanylidene-1H-quinazolin-4-one chemical structure, C20H19ClN4O2S, CAS 422528-86-7

3-[2-[4-(3-Chlorophenyl)piperazin-1-yl]-2-oxoethyl]-2-sulfanylidene-1H-quinazolin-4-one

CAS 422528-86-7C₂₀H₁₉ClN₄O₂S

3-[2-[4-(2-Methoxyphenyl)piperazin-1-yl]-2-oxoethyl]-2-sulfanylidene-1H-quinazolin-4-one chemical structure, C21H22N4O3S, CAS 422528-74-3

3-[2-[4-(2-Methoxyphenyl)piperazin-1-yl]-2-oxoethyl]-2-sulfanylidene-1H-quinazolin-4-one

CAS 422528-74-3C₂₁H₂₂N₄O₃S

3-[2-[4-(4-Methoxyphenyl)piperazin-1-yl]-2-oxoethyl]-2-sulfanylidene-1H-quinazolin-4-one chemical structure, C21H22N4O3S, CAS 451466-22-1

3-[2-[4-(4-Methoxyphenyl)piperazin-1-yl]-2-oxoethyl]-2-sulfanylidene-1H-quinazolin-4-one

CAS 451466-22-1C₂₁H₂₂N₄O₃S

3-[2-[4-(4-Fluorophenyl)piperazin-1-yl]-2-oxoethyl]-2-sulfanylidene-1H-quinazolin-4-one chemical structure, C20H19FN4O2S, CAS 422528-45-8

3-[2-[4-(4-Fluorophenyl)piperazin-1-yl]-2-oxoethyl]-2-sulfanylidene-1H-quinazolin-4-one

CAS 422528-45-8C₂₀H₁₉FN₄O₂S

3-[2-Oxo-2-(4-phenylpiperazin-1-yl)ethyl]-2-sulfanylidene-1H-quinazolin-4-one chemical structure, C20H20N4O2S, CAS 422528-16-3

3-[2-Oxo-2-(4-phenylpiperazin-1-yl)ethyl]-2-sulfanylidene-1H-quinazolin-4-one

CAS 422528-16-3C₂₀H₂₀N₄O₂S

Methyl 4-oxo-3-(2-oxo-2-(4-phenylpiperazin-1-yl)ethyl)-2-thioxo-1,2,3,4-tetrahydroquinazoline-7-carboxylate chemical structure, C22H22N4O4S, CAS 946329-14-2

Methyl 4-oxo-3-(2-oxo-2-(4-phenylpiperazin-1-yl)ethyl)-2-thioxo-1,2,3,4-tetrahydroquinazoline-7-carboxylate

CAS 946329-14-2C₂₂H₂₂N₄O₄S

Methyl 3-(2-(4-(4-fluorophenyl)piperazin-1-yl)-2-oxoethyl)-4-oxo-2-thioxo-1,2,3,4-tetrahydroquinazoline-7-carboxylate chemical structure, C22H21FN4O4S, CAS 946216-05-3

Methyl 3-(2-(4-(4-fluorophenyl)piperazin-1-yl)-2-oxoethyl)-4-oxo-2-thioxo-1,2,3,4-tetrahydroquinazoline-7-carboxylate

CAS 946216-05-3C₂₂H₂₁FN₄O₄S

Methyl 3-(2-(4-(2-methoxyphenyl)piperazin-1-yl)-2-oxoethyl)-4-oxo-2-thioxo-1,2,3,4-tetrahydroquinazoline-7-carboxylate chemical structure, C23H24N4O5S, CAS 946252-94-4

Methyl 3-(2-(4-(2-methoxyphenyl)piperazin-1-yl)-2-oxoethyl)-4-oxo-2-thioxo-1,2,3,4-tetrahydroquinazoline-7-carboxylate

CAS 946252-94-4C₂₃H₂₄N₄O₅S

Methyl 3-(2-(4-(2,5-dimethylphenyl)piperazin-1-yl)-2-oxoethyl)-4-oxo-2-thioxo-1,2,3,4-tetrahydroquinazoline-7-carboxylate chemical structure, C24H26N4O4S, CAS 946253-00-5

Methyl 3-(2-(4-(2,5-dimethylphenyl)piperazin-1-yl)-2-oxoethyl)-4-oxo-2-thioxo-1,2,3,4-tetrahydroquinazoline-7-carboxylate

CAS 946253-00-5C₂₄H₂₆N₄O₄S

Methyl 3-(2-(4-(2-fluorophenyl)piperazin-1-yl)-2-oxoethyl)-4-oxo-2-thioxo-1,2,3,4-tetrahydroquinazoline-7-carboxylate chemical structure, C22H21FN4O4S, CAS 946353-28-2

Methyl 3-(2-(4-(2-fluorophenyl)piperazin-1-yl)-2-oxoethyl)-4-oxo-2-thioxo-1,2,3,4-tetrahydroquinazoline-7-carboxylate

CAS 946353-28-2C₂₂H₂₁FN₄O₄S

Methyl 3-(2-(4-(2,3-dimethylphenyl)piperazin-1-yl)-2-oxoethyl)-4-oxo-2-thioxo-1,2,3,4-tetrahydroquinazoline-7-carboxylate chemical structure, C24H26N4O4S, CAS 946329-30-2

Methyl 3-(2-(4-(2,3-dimethylphenyl)piperazin-1-yl)-2-oxoethyl)-4-oxo-2-thioxo-1,2,3,4-tetrahydroquinazoline-7-carboxylate

CAS 946329-30-2C₂₄H₂₆N₄O₄S

Methyl 3-(2-(4-(5-chloro-2-methylphenyl)piperazin-1-yl)-2-oxoethyl)-4-oxo-2-thioxo-1,2,3,4-tetrahydroquinazoline-7-carboxylate chemical structure, C23H23ClN4O4S, CAS 946253-03-8

Methyl 3-(2-(4-(5-chloro-2-methylphenyl)piperazin-1-yl)-2-oxoethyl)-4-oxo-2-thioxo-1,2,3,4-tetrahydroquinazoline-7-carboxylate

CAS 946253-03-8C₂₃H₂₃ClN₄O₄S