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Murcko scaffold

Ring system with 4 rings and 28 atoms

14 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 28
Chemicals: 14
With full pages: 3

Scaffold SMILES

O=C1NC(c2ccncc2)C(=Cc2ccc(OCc3ccccc3)cc2)C1=O

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C1NC(c2ccncc2)C(=Cc2ccc(OCc3ccccc3)cc2)C1=O

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 14 of 14 chemicals

4-[4-(Benzyloxy)-2-methylbenzoyl]-1-[3-(dimethylamino)propyl]-3-hydroxy-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C29H31N3O4

4-[4-(Benzyloxy)-2-methylbenzoyl]-1-[3-(dimethylamino)propyl]-3-hydroxy-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

C₂₉H₃₁N₃O₄

4-[4-(Benzyloxy)benzoyl]-1-[3-(dimethylamino)propyl]-3-hydroxy-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C28H29N3O4

4-[4-(Benzyloxy)benzoyl]-1-[3-(dimethylamino)propyl]-3-hydroxy-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

C₂₈H₂₉N₃O₄

4-[4-(Benzyloxy)benzoyl]-3-hydroxy-1-(3-methoxypropyl)-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C27H26N2O5

4-[4-(Benzyloxy)benzoyl]-3-hydroxy-1-(3-methoxypropyl)-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

C₂₇H₂₆N₂O₅

1-[3-(Dimethylamino)propyl]-3-hydroxy-4-{4-[(2-methylphenyl)methoxy]benzoyl}-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C29H31N3O4

1-[3-(Dimethylamino)propyl]-3-hydroxy-4-{4-[(2-methylphenyl)methoxy]benzoyl}-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

C₂₉H₃₁N₃O₄

4-[4-(Benzyloxy)benzoyl]-3-hydroxy-1-(2-methoxyethyl)-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C26H24N2O5

4-[4-(Benzyloxy)benzoyl]-3-hydroxy-1-(2-methoxyethyl)-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

C₂₆H₂₄N₂O₅

4-[4-(Benzyloxy)-3-methylbenzoyl]-1-[3-(dimethylamino)propyl]-3-hydroxy-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C29H31N3O4, CAS 488732-45-2

4-[4-(Benzyloxy)-3-methylbenzoyl]-1-[3-(dimethylamino)propyl]-3-hydroxy-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

CAS 488732-45-2C₂₉H₃₁N₃O₄

4-[4-(Benzyloxy)-2-methylbenzoyl]-1-[3-(dimethylamino)propyl]-3-hydroxy-5-(4-pyridinyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C29H31N3O4, CAS 487032-07-5

4-[4-(Benzyloxy)-2-methylbenzoyl]-1-[3-(dimethylamino)propyl]-3-hydroxy-5-(4-pyridinyl)-1,5-dihydro-2H-pyrrol-2-one

CAS 487032-07-5C₂₉H₃₁N₃O₄

4-(4-(Benzyloxy)-2-methylbenzoyl)-3-hydroxy-1-(2-methoxyethyl)-5-(4-pyridinyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C27H26N2O5, CAS 487022-17-3

4-(4-(Benzyloxy)-2-methylbenzoyl)-3-hydroxy-1-(2-methoxyethyl)-5-(4-pyridinyl)-1,5-dihydro-2H-pyrrol-2-one

CAS 487022-17-3C₂₇H₂₆N₂O₅

4-[4-(Benzyloxy)-2-methylbenzoyl]-1-[2-(dimethylamino)ethyl]-3-hydroxy-5-(4-pyridinyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C28H29N3O4, CAS 488716-22-9

4-[4-(Benzyloxy)-2-methylbenzoyl]-1-[2-(dimethylamino)ethyl]-3-hydroxy-5-(4-pyridinyl)-1,5-dihydro-2H-pyrrol-2-one

CAS 488716-22-9C₂₈H₂₉N₃O₄

(4E)-1-[3-(Dimethylamino)propyl]-4-[hydroxy-(4-phenylmethoxyphenyl)methylidene]-5-pyridin-4-ylpyrrolidine-2,3-dione chemical structure, C28H29N3O4, CAS 846031-01-4

(4E)-1-[3-(Dimethylamino)propyl]-4-[hydroxy-(4-phenylmethoxyphenyl)methylidene]-5-pyridin-4-ylpyrrolidine-2,3-dione

CAS 846031-01-4C₂₈H₂₉N₃O₄

(4E)-4-{[4-(Benzyloxy)phenyl](hydroxy)methylidene}-1-(3-methoxypropyl)-5-(pyridin-4-yl)pyrrolidine-2,3-dione chemical structure, C27H26N2O5, CAS 847376-09-4

(4E)-4-{[4-(Benzyloxy)phenyl](hydroxy)methylidene}-1-(3-methoxypropyl)-5-(pyridin-4-yl)pyrrolidine-2,3-dione

CAS 847376-09-4C₂₇H₂₆N₂O₅

(4E)-4-{[4-(Benzyloxy)phenyl](hydroxy)methylidene}-1-(2-methoxyethyl)-5-(pyridin-4-yl)pyrrolidine-2,3-dione chemical structure, C26H24N2O5, CAS 848222-59-3

(4E)-4-{[4-(Benzyloxy)phenyl](hydroxy)methylidene}-1-(2-methoxyethyl)-5-(pyridin-4-yl)pyrrolidine-2,3-dione

CAS 848222-59-3C₂₆H₂₄N₂O₅

(4E)-1-[3-(Dimethylamino)propyl]-4-[hydroxy-[4-[(2-methylphenyl)methoxy]phenyl]methylidene]-5-pyridin-4-ylpyrrolidine-2,3-dione chemical structure, C29H31N3O4, CAS 843633-10-3

(4E)-1-[3-(Dimethylamino)propyl]-4-[hydroxy-[4-[(2-methylphenyl)methoxy]phenyl]methylidene]-5-pyridin-4-ylpyrrolidine-2,3-dione

CAS 843633-10-3C₂₉H₃₁N₃O₄

4-(4-(Benzyloxy)-2-methylbenzoyl)-1-(2-(diethylamino)ethyl)-3-hydroxy-5-(4-pyridinyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C30H33N3O4, CAS 488132-09-8

4-(4-(Benzyloxy)-2-methylbenzoyl)-1-(2-(diethylamino)ethyl)-3-hydroxy-5-(4-pyridinyl)-1,5-dihydro-2H-pyrrol-2-one

CAS 488132-09-8C₃₀H₃₃N₃O₄