Murcko scaffold
Ring system with 4 rings and 28 atoms
75 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 28
- Chemicals
- 75
- With full pages
- 34
Scaffold SMILES
O=C1NC(c2ccccc2)C(=Cc2ccc(OCc3ccccc3)cc2)C1=O
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 75 chemicals
4-(4-(Benzyloxy)-2-methylbenzoyl)-5-(3,4-dimethoxyphenyl)-1-(2-(dimethylamino)ethyl)-3-hydroxy-1H-pyrrol-2(5H)-one
CAS 488095-48-3C31H34N2O6
![1-[2-(Dimethylamino)ethyl]-5-(4-ethylphenyl)-3-hydroxy-4-{4-[(3-methylphenyl)methoxy]benzoyl}-2,5-dihydro-1H-pyrrol-2-one chemical structure, C31H34N2O4](/s/ADEYCQNKPYPMAD-UHFFFAOYSA-N.svg)
1-[2-(Dimethylamino)ethyl]-5-(4-ethylphenyl)-3-hydroxy-4-{4-[(3-methylphenyl)methoxy]benzoyl}-2,5-dihydro-1H-pyrrol-2-one
C31H34N2O4
![1-[2-(Dimethylamino)ethyl]-5-(2-fluorophenyl)-3-hydroxy-4-{4-[(3-methylphenyl)methoxy]benzoyl}-2,5-dihydro-1H-pyrrol-2-one chemical structure, C29H29FN2O4](/s/SGFLWGQMDSFOCR-UHFFFAOYSA-N.svg)
1-[2-(Dimethylamino)ethyl]-5-(2-fluorophenyl)-3-hydroxy-4-{4-[(3-methylphenyl)methoxy]benzoyl}-2,5-dihydro-1H-pyrrol-2-one
C29H29FN2O4
![4-[4-(Benzyloxy)-3-methylbenzoyl]-1-[3-(dimethylamino)propyl]-3-hydroxy-5-phenyl-2,5-dihydro-1H-pyrrol-2-one chemical structure, C30H32N2O4](/s/JNOZUXKAQMAEHQ-UHFFFAOYSA-N.svg)
4-[4-(Benzyloxy)-3-methylbenzoyl]-1-[3-(dimethylamino)propyl]-3-hydroxy-5-phenyl-2,5-dihydro-1H-pyrrol-2-one
C30H32N2O4
![4-[4-(Benzyloxy)benzoyl]-5-(4-chlorophenyl)-1-[2-(dimethylamino)ethyl]-3-hydroxy-2,5-dihydro-1H-pyrrol-2-one chemical structure, C28H27ClN2O4](/s/AYHZSZXMUZDMDY-UHFFFAOYSA-N.svg)
4-[4-(Benzyloxy)benzoyl]-5-(4-chlorophenyl)-1-[2-(dimethylamino)ethyl]-3-hydroxy-2,5-dihydro-1H-pyrrol-2-one
C28H27ClN2O4
4-(4-(Benzyloxy)-2-methylbenzoyl)-5-(4-ethoxy-3-methoxyphenyl)-3-hydroxy-1-(2-methoxyethyl)-1H-pyrrol-2(5H)-one
CAS 488734-39-0C31H33NO7
![4-[4-(Benzyloxy)-3-methylbenzoyl]-1-[2-(dimethylamino)ethyl]-3-hydroxy-5-(4-methylphenyl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C30H32N2O4](/s/GEJQPRPMNKQLLZ-UHFFFAOYSA-N.svg)
4-[4-(Benzyloxy)-3-methylbenzoyl]-1-[2-(dimethylamino)ethyl]-3-hydroxy-5-(4-methylphenyl)-2,5-dihydro-1H-pyrrol-2-one
C30H32N2O4
![4-[4-(Benzyloxy)benzoyl]-1-[3-(dimethylamino)propyl]-3-hydroxy-5-(4-hydroxyphenyl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C29H30N2O5](/s/MEVYPRBPGQJTIK-UHFFFAOYSA-N.svg)
4-[4-(Benzyloxy)benzoyl]-1-[3-(dimethylamino)propyl]-3-hydroxy-5-(4-hydroxyphenyl)-2,5-dihydro-1H-pyrrol-2-one
C29H30N2O5
![4-[4-(Benzyloxy)benzoyl]-3-hydroxy-5-(4-hydroxyphenyl)-1-(2-methoxyethyl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C27H25NO6](/s/AKTQJJAGVSNQJC-UHFFFAOYSA-N.svg)
4-[4-(Benzyloxy)benzoyl]-3-hydroxy-5-(4-hydroxyphenyl)-1-(2-methoxyethyl)-2,5-dihydro-1H-pyrrol-2-one
C27H25NO6
![4-[4-(Benzyloxy)benzoyl]-1-[3-(dimethylamino)propyl]-5-(4-fluorophenyl)-3-hydroxy-2,5-dihydro-1H-pyrrol-2-one chemical structure, C29H29FN2O4](/s/HWLMUABTCRJODS-UHFFFAOYSA-N.svg)
4-[4-(Benzyloxy)benzoyl]-1-[3-(dimethylamino)propyl]-5-(4-fluorophenyl)-3-hydroxy-2,5-dihydro-1H-pyrrol-2-one
C29H29FN2O4
![1-[2-(Dimethylamino)ethyl]-3-hydroxy-5-(3-hydroxyphenyl)-4-{4-[(2-methylphenyl)methoxy]benzoyl}-2,5-dihydro-1H-pyrrol-2-one chemical structure, C29H30N2O5](/s/LKOJTLPCNBPVCG-UHFFFAOYSA-N.svg)
1-[2-(Dimethylamino)ethyl]-3-hydroxy-5-(3-hydroxyphenyl)-4-{4-[(2-methylphenyl)methoxy]benzoyl}-2,5-dihydro-1H-pyrrol-2-one
C29H30N2O5
![4-[4-(Benzyloxy)-3-methylbenzoyl]-1-[3-(dimethylamino)propyl]-3-hydroxy-5-(4-methylphenyl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C31H34N2O4](/s/SGBWOXKSNCBIKM-UHFFFAOYSA-N.svg)
4-[4-(Benzyloxy)-3-methylbenzoyl]-1-[3-(dimethylamino)propyl]-3-hydroxy-5-(4-methylphenyl)-2,5-dihydro-1H-pyrrol-2-one
C31H34N2O4
![4-[4-(Benzyloxy)-2-methylbenzoyl]-1-[2-(dimethylamino)ethyl]-5-(4-fluorophenyl)-3-hydroxy-2,5-dihydro-1H-pyrrol-2-one chemical structure, C29H29FN2O4](/s/HMWAYOBSKKSKCL-UHFFFAOYSA-N.svg)
4-[4-(Benzyloxy)-2-methylbenzoyl]-1-[2-(dimethylamino)ethyl]-5-(4-fluorophenyl)-3-hydroxy-2,5-dihydro-1H-pyrrol-2-one
C29H29FN2O4
![1-[2-(Dimethylamino)ethyl]-3-hydroxy-5-(4-hydroxyphenyl)-4-{4-[(2-methylphenyl)methoxy]benzoyl}-2,5-dihydro-1H-pyrrol-2-one chemical structure, C29H30N2O5](/s/YNUISYBVTIBNIU-UHFFFAOYSA-N.svg)
1-[2-(Dimethylamino)ethyl]-3-hydroxy-5-(4-hydroxyphenyl)-4-{4-[(2-methylphenyl)methoxy]benzoyl}-2,5-dihydro-1H-pyrrol-2-one
C29H30N2O5
![4-[4-(Benzyloxy)-3-methylbenzoyl]-1-[2-(dimethylamino)ethyl]-5-(4-fluorophenyl)-3-hydroxy-2,5-dihydro-1H-pyrrol-2-one chemical structure, C29H29FN2O4](/s/UOWONNOGKCGEHK-UHFFFAOYSA-N.svg)
4-[4-(Benzyloxy)-3-methylbenzoyl]-1-[2-(dimethylamino)ethyl]-5-(4-fluorophenyl)-3-hydroxy-2,5-dihydro-1H-pyrrol-2-one
C29H29FN2O4
![4-[4-(Benzyloxy)benzoyl]-1-[3-(dimethylamino)propyl]-3-hydroxy-5-phenyl-2,5-dihydro-1H-pyrrol-2-one chemical structure, C29H30N2O4](/s/GHMTURSMRXSRMZ-UHFFFAOYSA-N.svg)
4-[4-(Benzyloxy)benzoyl]-1-[3-(dimethylamino)propyl]-3-hydroxy-5-phenyl-2,5-dihydro-1H-pyrrol-2-one
C29H30N2O4
4-(4-(Benzyloxy)-2-methylbenzoyl)-1-(2-(dimethylamino)ethyl)-3-hydroxy-5-(3-nitrophenyl)-1H-pyrrol-2(5H)-one
CAS 499116-79-9C29H29N3O6
![4-[4-(Benzyloxy)-3-methylbenzoyl]-1-[2-(dimethylamino)ethyl]-5-(4-ethylphenyl)-3-hydroxy-2,5-dihydro-1H-pyrrol-2-one chemical structure, C31H34N2O4](/s/VYMJSXTXJCSUIY-UHFFFAOYSA-N.svg)
4-[4-(Benzyloxy)-3-methylbenzoyl]-1-[2-(dimethylamino)ethyl]-5-(4-ethylphenyl)-3-hydroxy-2,5-dihydro-1H-pyrrol-2-one
C31H34N2O4
![4-[4-(Benzyloxy)benzoyl]-1-[2-(dimethylamino)ethyl]-3-hydroxy-5-(4-hydroxyphenyl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C28H28N2O5](/s/YYPBJROCEHJCAM-UHFFFAOYSA-N.svg)
4-[4-(Benzyloxy)benzoyl]-1-[2-(dimethylamino)ethyl]-3-hydroxy-5-(4-hydroxyphenyl)-2,5-dihydro-1H-pyrrol-2-one
C28H28N2O5
![4-[4-(Benzyloxy)-2-methylbenzoyl]-1-[2-(dimethylamino)ethyl]-3-hydroxy-5-phenyl-2,5-dihydro-1H-pyrrol-2-one chemical structure, C29H30N2O4](/s/JULJVUDUVIOFGY-UHFFFAOYSA-N.svg)
4-[4-(Benzyloxy)-2-methylbenzoyl]-1-[2-(dimethylamino)ethyl]-3-hydroxy-5-phenyl-2,5-dihydro-1H-pyrrol-2-one
C29H30N2O4
4-(4-(Benzyloxy)-2-methylbenzoyl)-5-(3,4-dimethoxyphenyl)-3-hydroxy-1-(3-methoxypropyl)-1H-pyrrol-2(5H)-one
CAS 489462-56-8C31H33NO7
4-(4-(Benzyloxy)-2-methylbenzoyl)-5-(3-bromophenyl)-3-hydroxy-1-(3-methoxypropyl)-1H-pyrrol-2(5H)-one
CAS 500146-47-4C29H28BrNO5
![1-[2-(Dimethylamino)ethyl]-3-hydroxy-5-(4-hydroxyphenyl)-4-{4-[(3-methylphenyl)methoxy]benzoyl}-2,5-dihydro-1H-pyrrol-2-one chemical structure, C29H30N2O5](/s/ODYSZAWBLJJJOP-UHFFFAOYSA-N.svg)
1-[2-(Dimethylamino)ethyl]-3-hydroxy-5-(4-hydroxyphenyl)-4-{4-[(3-methylphenyl)methoxy]benzoyl}-2,5-dihydro-1H-pyrrol-2-one
C29H30N2O5
![4-[4-(Benzyloxy)-2-methylbenzoyl]-1-[3-(dimethylamino)propyl]-3-hydroxy-5-(4-methylphenyl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C31H34N2O4](/s/DWMPGVMNGDYFHK-UHFFFAOYSA-N.svg)
4-[4-(Benzyloxy)-2-methylbenzoyl]-1-[3-(dimethylamino)propyl]-3-hydroxy-5-(4-methylphenyl)-2,5-dihydro-1H-pyrrol-2-one
C31H34N2O4
- 4-(4-(Benzyloxy)-2-methylbenzoyl)-5-(3-bromophenyl)-3-hydroxy-1-(2-methoxyethyl)-1H-pyrrol-2(5H)-one488853-85-6C28H26BrNO5
- 4-(4-(Benzyloxy)-2-methylbenzoyl)-3-hydroxy-1-(2-methoxyethyl)-5-(3-nitrophenyl)-1H-pyrrol-2(5H)-one488725-11-7C28H26N2O7
- 4-(4-(Benzyloxy)-2-methylbenzoyl)-3-hydroxy-1-(2-methoxyethyl)-5-(4-nitrophenyl)-1H-pyrrol-2(5H)-oneC28H26N2O7
- 4-[Hydroxy-[4-[(3-methylphenyl)methoxy]phenyl]methylidene]-1-(3-methoxypropyl)-5-(3-nitrophenyl)pyrrolidine-2,3-dione4861-80-7C29H28N2O7
- [2-(3,4-Dichlorophenyl)-1-[2-(diethylazaniumyl)ethyl]-4,5-dioxopyrrolidin-3-ylidene]-(2-methyl-4-phenylmethoxyphenyl)methanolate5706-67-2C31H32Cl2N2O4
- 4-[4-(Benzyloxy)-3-methylbenzoyl]-1-[2-(dimethylamino)ethyl]-3-hydroxy-5-(4-hydroxyphenyl)-1,5-dihydro-2H-pyrrol-2-one500104-79-0C29H30N2O5
- 4-(4-(Benzyloxy)-2-methylbenzoyl)-1-(2-(dimethylamino)ethyl)-3-hydroxy-5-(4-hydroxyphenyl)-1,5-dihydro-2H-pyrrol-2-one488094-42-4C29H30N2O5
- 4-[4-(Benzyloxy)-2-methylbenzoyl]-5-(3-ethoxy-4-hydroxyphenyl)-3-hydroxy-1-(2-methoxyethyl)-1,5-dihydro-2H-pyrrol-2-one488123-24-6C30H31NO7
- (4E)-1-[2-(Dimethylamino)ethyl]-5-(4-ethylphenyl)-4-[hydroxy-[4-[(3-methylphenyl)methoxy]phenyl]methylidene]pyrrolidine-2,3-dione840455-60-9C31H34N2O4
- 1-[2-(Dimethylamino)ethyl]-5-(2-fluorophenyl)-3-hydroxy-4-{4-[(3-methylbenzyl)oxy]benzoyl}-1,5-dihydro-2H-pyrrol-2-one836634-18-5C29H29FN2O4
- 4-[4-(Benzyloxy)-2-methylbenzoyl]-1-[2-(dimethylamino)ethyl]-5-(3-ethoxy-4-hydroxyphenyl)-3-hydroxy-1,5-dihydro-2H-pyrrol-2-one498537-61-4C31H34N2O6
- 4-[4-(Benzyloxy)-2-methylbenzoyl]-1-[2-(diethylamino)ethyl]-3-hydroxy-5-(4-hydroxy-3-methoxyphenyl)-1,5-dihydro-2H-pyrrol-2-one499210-42-3C32H36N2O6
- 4-[4-(Benzyloxy)-2-methylbenzoyl]-5-(4-chlorophenyl)-1-[2-(diethylamino)ethyl]-3-hydroxy-1,5-dihydro-2H-pyrrol-2-one498569-22-5C31H33ClN2O4
- 4-(4-(Benzyloxy)benzoyl)-5-(4-chlorophenyl)-1-(2-(dimethylamino)ethyl)-3-hydroxy-1H-pyrrol-2(5H)-one844860-37-3C28H27ClN2O4
- 4-{[4-(Benzyloxy)-3-methylphenyl]carbonyl}-1-[3-(dimethylamino)propyl]-3-hydroxy-5-phenyl-1,5-dihydro-2H-pyrrol-2-one489441-88-5C30H32N2O4
- (4E)-1-[3-(Dimethylamino)propyl]-5-(4-hydroxyphenyl)-4-[hydroxy-(4-phenylmethoxyphenyl)methylidene]pyrrolidine-2,3-dione847854-74-4C29H30N2O5
- (4E)-4-{[4-(Benzyloxy)phenyl](hydroxy)methylidene}-5-(4-hydroxyphenyl)-1-(2-methoxyethyl)pyrrolidine-2,3-dione844836-08-4C27H25NO6
- 4-(4-(Benzyloxy)benzoyl)-1-(3-(dimethylamino)propyl)-5-(4-fluorophenyl)-3-hydroxy-1H-pyrrol-2(5H)-one845806-32-8C29H29FN2O4
- 4-(4-(Benzyloxy)-2-methylbenzoyl)-1-(2-(dimethylamino)ethyl)-5-(4-ethoxyphenyl)-3-hydroxy-1,5-dihydro-2H-pyrrol-2-one487020-60-0C31H34N2O5
- 4-{[4-(Benzyloxy)-3-methylphenyl]carbonyl}-1-[2-(dimethylamino)ethyl]-3-hydroxy-5-(4-methylphenyl)-1,5-dihydro-2H-pyrrol-2-one488708-49-2C30H32N2O4
- 4-{[4-(Benzyloxy)-3-methylphenyl]carbonyl}-1-[3-(dimethylamino)propyl]-3-hydroxy-5-(4-methylphenyl)-1,5-dihydro-2H-pyrrol-2-one497228-40-7C31H34N2O4
- 4-[4-(Benzyloxy)-2-methylbenzoyl]-1-[2-(dimethylamino)ethyl]-5-(4-fluorophenyl)-3-hydroxy-1,5-dihydro-2H-pyrrol-2-one488746-60-7C29H29FN2O4
- (4E)-1-[2-(Dimethylamino)ethyl]-4-[hydroxy-[4-[(2-methylphenyl)methoxy]phenyl]methylidene]-5-(4-hydroxyphenyl)pyrrolidine-2,3-dione840497-60-1C29H30N2O5
- (4E)-1-[2-(Dimethylamino)ethyl]-4-[hydroxy-[4-[(2-methylphenyl)methoxy]phenyl]methylidene]-5-(3-hydroxyphenyl)pyrrolidine-2,3-dione840517-67-1C29H30N2O5
Related scaffolds
Same ring framework with different atoms or bond orders
