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Murcko scaffold

Ring system with 4 rings and 29 atoms

85 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
29
Chemicals
85
With full pages
5
Scaffold SMILES

O=C(CSc1nc2ccccc2n1Cc1ccccc1)NN=Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSc1nc2ccccc2n1Cc1ccccc1)NN=Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 85 chemicals

2-[[1-[(4-Chlorophenyl)methyl]-1H-benzimidazol-2-yl]thio]acetic acid 2-[(4-chlorophenyl)methylene]hydrazide chemical structure, C23H18Cl2N4OS, CAS 304449-55-6
2-[[1-[(4-Chlorophenyl)methyl]-1H-benzimidazol-2-yl]thio]acetic acid 2-[(4-chlorophenyl)methylene]hydrazide
CAS 304449-55-6C23H18Cl2N4OS
2-(1-Benzylbenzimidazol-2-yl)sulfanyl-N-[(E)-(2-ethoxyphenyl)methylideneamino]acetamide chemical structure, C25H24N4O2S, CAS 306990-01-2
2-(1-Benzylbenzimidazol-2-yl)sulfanyl-N-[(E)-(2-ethoxyphenyl)methylideneamino]acetamide
CAS 306990-01-2C25H24N4O2S
2-(1-Benzylbenzimidazol-2-yl)sulfanyl-N-[(E)-(4-nitrophenyl)methylideneamino]acetamide chemical structure, C23H19N5O3S, CAS 306951-46-2
2-(1-Benzylbenzimidazol-2-yl)sulfanyl-N-[(E)-(4-nitrophenyl)methylideneamino]acetamide
CAS 306951-46-2C23H19N5O3S
2-[(1-Benzyl-1H-benzimidazol-2-yl)sulfanyl]-N'-[(E)-(4-ethoxyphenyl)methylidene]acetohydrazide chemical structure, C25H24N4O2S, CAS 306951-12-2
2-[(1-Benzyl-1H-benzimidazol-2-yl)sulfanyl]-N'-[(E)-(4-ethoxyphenyl)methylidene]acetohydrazide
CAS 306951-12-2C25H24N4O2S
2-[(1-Benzyl-1H-benzimidazol-2-yl)sulfanyl]-N'-[(E)-(4-bromophenyl)methylidene]acetohydrazide chemical structure, C23H19BrN4OS, CAS 306951-36-0
2-[(1-Benzyl-1H-benzimidazol-2-yl)sulfanyl]-N'-[(E)-(4-bromophenyl)methylidene]acetohydrazide
CAS 306951-36-0C23H19BrN4OS
2-[(1-Benzyl-1H-benzimidazol-2-yl)sulfanyl]-N'-[(E)-(3-bromophenyl)methylidene]acetohydrazide chemical structure, C23H19BrN4OS, CAS 306990-00-1
2-[(1-Benzyl-1H-benzimidazol-2-yl)sulfanyl]-N'-[(E)-(3-bromophenyl)methylidene]acetohydrazide
CAS 306990-00-1C23H19BrN4OS
2-(1-Benzylbenzimidazol-2-yl)sulfanyl-N-[(E)-(3-chlorophenyl)methylideneamino]acetamide chemical structure, C23H19ClN4OS, CAS 306990-14-7
2-(1-Benzylbenzimidazol-2-yl)sulfanyl-N-[(E)-(3-chlorophenyl)methylideneamino]acetamide
CAS 306990-14-7C23H19ClN4OS
2-(1-Benzylbenzimidazol-2-yl)sulfanyl-N-[(E)-(2,3-dichlorophenyl)methylideneamino]acetamide chemical structure, C23H18Cl2N4OS, CAS 306990-16-9
2-(1-Benzylbenzimidazol-2-yl)sulfanyl-N-[(E)-(2,3-dichlorophenyl)methylideneamino]acetamide
CAS 306990-16-9C23H18Cl2N4OS
2-[(1-Benzyl-1H-benzimidazol-2-yl)sulfanyl]-N'-[(1E)-1-phenylethylidene]acetohydrazide chemical structure, C24H22N4OS, CAS 306750-39-0
2-[(1-Benzyl-1H-benzimidazol-2-yl)sulfanyl]-N'-[(1E)-1-phenylethylidene]acetohydrazide
CAS 306750-39-0C24H22N4OS
2-[(1-Benzyl-1H-benzimidazol-2-yl)sulfanyl]-N'-[(E)-(3-hydroxyphenyl)methylidene]acetohydrazide chemical structure, C23H20N4O2S, CAS 306990-19-2
2-[(1-Benzyl-1H-benzimidazol-2-yl)sulfanyl]-N'-[(E)-(3-hydroxyphenyl)methylidene]acetohydrazide
CAS 306990-19-2C23H20N4O2S
2-(1-Benzylbenzimidazol-2-yl)sulfanyl-N-[(E)-(2-bromophenyl)methylideneamino]acetamide chemical structure, C23H19BrN4OS, CAS 306951-23-5
2-(1-Benzylbenzimidazol-2-yl)sulfanyl-N-[(E)-(2-bromophenyl)methylideneamino]acetamide
CAS 306951-23-5C23H19BrN4OS
2-(1-Benzylbenzimidazol-2-yl)sulfanyl-N-[(E)-(2-methoxyphenyl)methylideneamino]acetamide chemical structure, C24H22N4O2S, CAS 306951-44-0
2-(1-Benzylbenzimidazol-2-yl)sulfanyl-N-[(E)-(2-methoxyphenyl)methylideneamino]acetamide
CAS 306951-44-0C24H22N4O2S
2-[(1-Benzyl-1H-benzimidazol-2-yl)sulfanyl]-N'-[(E)-(4-chlorophenyl)methylidene]acetohydrazide chemical structure, C23H19ClN4OS, CAS 306951-32-6
2-[(1-Benzyl-1H-benzimidazol-2-yl)sulfanyl]-N'-[(E)-(4-chlorophenyl)methylidene]acetohydrazide
CAS 306951-32-6C23H19ClN4OS
2-[(1-Benzyl-1H-benzimidazol-2-yl)sulfanyl]-N'-[(E)-(2,3-dimethoxyphenyl)methylidene]acetohydrazide chemical structure, C25H24N4O3S, CAS 306990-17-0
2-[(1-Benzyl-1H-benzimidazol-2-yl)sulfanyl]-N'-[(E)-(2,3-dimethoxyphenyl)methylidene]acetohydrazide
CAS 306990-17-0C25H24N4O3S
[4-[(Z)-N-[[2-(1-Benzylbenzimidazol-2-yl)sulfanylacetyl]amino]-C-methylcarbonimidoyl]phenyl] acetate chemical structure, C26H24N4O3S, CAS 315215-43-1
[4-[(Z)-N-[[2-(1-Benzylbenzimidazol-2-yl)sulfanylacetyl]amino]-C-methylcarbonimidoyl]phenyl] acetate
CAS 315215-43-1C26H24N4O3S
[4-[(Z)-C-Methyl-N-[[2-[1-[(4-methylphenyl)methyl]benzimidazol-2-yl]sulfanylacetyl]amino]carbonimidoyl]phenyl] acetate chemical structure, C27H26N4O3S, CAS 306285-60-9
[4-[(Z)-C-Methyl-N-[[2-[1-[(4-methylphenyl)methyl]benzimidazol-2-yl]sulfanylacetyl]amino]carbonimidoyl]phenyl] acetate
CAS 306285-60-9C27H26N4O3S
2-(1-Benzylbenzimidazol-2-yl)sulfanyl-N-[(Z)-1-(4-fluorophenyl)ethylideneamino]acetamide chemical structure, C24H21FN4OS, CAS 315215-48-6
2-(1-Benzylbenzimidazol-2-yl)sulfanyl-N-[(Z)-1-(4-fluorophenyl)ethylideneamino]acetamide
CAS 315215-48-6C24H21FN4OS
2-{[1-(2-Chlorobenzyl)-1H-benzimidazol-2-yl]sulfanyl}-N'-[(E)-(3-hydroxyphenyl)methylidene]acetohydrazide chemical structure, C23H19ClN4O2S, CAS 314286-67-4
2-{[1-(2-Chlorobenzyl)-1H-benzimidazol-2-yl]sulfanyl}-N'-[(E)-(3-hydroxyphenyl)methylidene]acetohydrazide
CAS 314286-67-4C23H19ClN4O2S
2-[(1-Benzyl-1H-benzimidazol-2-yl)sulfanyl]-N'-[(E)-1-(4-bromophenyl)ethylidene]acetohydrazide chemical structure, C24H21BrN4OS, CAS 306951-54-2
2-[(1-Benzyl-1H-benzimidazol-2-yl)sulfanyl]-N'-[(E)-1-(4-bromophenyl)ethylidene]acetohydrazide
CAS 306951-54-2C24H21BrN4OS
2-{[1-(2-Chlorobenzyl)-1H-benzimidazol-2-yl]sulfanyl}-N'-[(1E)-1-phenylethylidene]acetohydrazide chemical structure, C24H21ClN4OS, CAS 314287-10-0
2-{[1-(2-Chlorobenzyl)-1H-benzimidazol-2-yl]sulfanyl}-N'-[(1E)-1-phenylethylidene]acetohydrazide
CAS 314287-10-0C24H21ClN4OS
2-[1-[(4-Chlorophenyl)methyl]benzimidazol-2-yl]sulfanyl-N-[(Z)-(2,6-dichlorophenyl)methylideneamino]acetamide chemical structure, C23H17Cl3N4OS, CAS 314068-02-5
2-[1-[(4-Chlorophenyl)methyl]benzimidazol-2-yl]sulfanyl-N-[(Z)-(2,6-dichlorophenyl)methylideneamino]acetamide
CAS 314068-02-5C23H17Cl3N4OS
2-{[1-(4-Chlorobenzyl)-1H-benzimidazol-2-yl]sulfanyl}-N'-[(E)-(4-methylphenyl)methylidene]acetohydrazide chemical structure, C24H21ClN4OS, CAS 314068-35-4
2-{[1-(4-Chlorobenzyl)-1H-benzimidazol-2-yl]sulfanyl}-N'-[(E)-(4-methylphenyl)methylidene]acetohydrazide
CAS 314068-35-4C24H21ClN4OS
2-{[1-(2-Chlorobenzyl)-1H-benzimidazol-2-yl]sulfanyl}-N'-[(E)-(4-isopropylphenyl)methylidene]acetohydrazide chemical structure, C26H25ClN4OS, CAS 314287-06-4
2-{[1-(2-Chlorobenzyl)-1H-benzimidazol-2-yl]sulfanyl}-N'-[(E)-(4-isopropylphenyl)methylidene]acetohydrazide
CAS 314287-06-4C26H25ClN4OS
2-(1-Benzylbenzimidazol-2-yl)sulfanyl-N-[(Z)-1-(4-chlorophenyl)ethylideneamino]acetamide chemical structure, C24H21ClN4OS, CAS 306951-53-1
2-(1-Benzylbenzimidazol-2-yl)sulfanyl-N-[(Z)-1-(4-chlorophenyl)ethylideneamino]acetamide
CAS 306951-53-1C24H21ClN4OS