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Murcko scaffold

2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-N-phenylacetamide scaffold

19 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
26
Chemicals
19
With full pages
2
Scaffold SMILES

O=C(CN1CCN(Cc2ccc3c(c2)OCO3)CC1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-N-phenylacetamide page
Murcko scaffold O=C(CN1CCN(Cc2ccc3c(c2)OCO3)CC1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 19 of 19 chemicals

2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-N-(4-fluorophenyl)acetamide chemical structure, C20H22FN3O3, CAS 723738-48-5
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-N-(4-fluorophenyl)acetamide
CAS 723738-48-5C20H22FN3O3
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-N-[4-(trifluoromethylsulfanyl)phenyl]acetamide chemical structure, C21H22F3N3O3S, CAS 499197-53-4
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-N-[4-(trifluoromethylsulfanyl)phenyl]acetamide
CAS 499197-53-4C21H22F3N3O3S
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-N-phenylacetamide chemical structure, C20H23N3O3, CAS 484027-59-0
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-N-phenylacetamide
CAS 484027-59-0C20H23N3O3
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-N-(2-ethylphenyl)acetamide chemical structure, C22H27N3O3, CAS 484027-61-4
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-N-(2-ethylphenyl)acetamide
CAS 484027-61-4C22H27N3O3
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-N-(2-fluorophenyl)acetamide chemical structure, C20H22FN3O3, CAS 484027-80-7
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-N-(2-fluorophenyl)acetamide
CAS 484027-80-7C20H22FN3O3
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-N-(4-methylphenyl)acetamide chemical structure, C21H25N3O3, CAS 439142-93-5
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-N-(4-methylphenyl)acetamide
CAS 439142-93-5C21H25N3O3
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-N-(4-chlorophenyl)acetamide chemical structure, C20H22ClN3O3, CAS 333758-61-5
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-N-(4-chlorophenyl)acetamide
CAS 333758-61-5C20H22ClN3O3
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-N-(2,5-dimethoxyphenyl)acetamide chemical structure, C22H27N3O5, CAS 484027-74-9
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-N-(2,5-dimethoxyphenyl)acetamide
CAS 484027-74-9C22H27N3O5
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-N-(2,4-difluorophenyl)acetamide chemical structure, C20H21F2N3O3, CAS 491867-65-3
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-N-(2,4-difluorophenyl)acetamide
CAS 491867-65-3C20H21F2N3O3
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-N-(4-sulfamoylphenyl)acetamide chemical structure, C20H24N4O5S, CAS 325729-20-2
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-N-(4-sulfamoylphenyl)acetamide
CAS 325729-20-2C20H24N4O5S
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-N-(4-methoxyphenyl)acetamide chemical structure, C21H25N3O4, CAS 432519-02-3
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-N-(4-methoxyphenyl)acetamide
CAS 432519-02-3C21H25N3O4
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-N-(4-ethylphenyl)acetamide chemical structure, C22H27N3O3, CAS 432534-03-7
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-N-(4-ethylphenyl)acetamide
CAS 432534-03-7C22H27N3O3
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-N-(3-chloro-2-methylphenyl)acetamide chemical structure, C21H24ClN3O3, CAS 404897-66-1
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-N-(3-chloro-2-methylphenyl)acetamide
CAS 404897-66-1C21H24ClN3O3
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-N-(4-chloro-2-methylphenyl)acetamide chemical structure, C21H24ClN3O3, CAS 433235-95-1
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-N-(4-chloro-2-methylphenyl)acetamide
CAS 433235-95-1C21H24ClN3O3
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-N-(3-chloro-4-fluorophenyl)acetamide chemical structure, C20H21ClFN3O3, CAS 850472-81-0
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-N-(3-chloro-4-fluorophenyl)acetamide
CAS 850472-81-0C20H21ClFN3O3
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-N-(2-chlorophenyl)acetamide chemical structure, C20H22ClN3O3, CAS 885446-68-4
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-N-(2-chlorophenyl)acetamide
CAS 885446-68-4C20H22ClN3O3
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-N-(2-ethoxyphenyl)acetamide chemical structure, C22H27N3O4, CAS 484027-71-6
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-N-(2-ethoxyphenyl)acetamide
CAS 484027-71-6C22H27N3O4
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-N-[3,5-bis(trifluoromethyl)phenyl]acetamide chemical structure, C22H21F6N3O3, CAS 1023546-52-2
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-N-[3,5-bis(trifluoromethyl)phenyl]acetamide
CAS 1023546-52-2C22H21F6N3O3
2-{4-[(2H-1,3-Benzodioxol-5-yl)methyl]piperazin-1-yl}-N-(3-sulfamoylphenyl)acetamide chemical structure, C20H24N4O5S, CAS 5474-23-7
2-{4-[(2H-1,3-Benzodioxol-5-yl)methyl]piperazin-1-yl}-N-(3-sulfamoylphenyl)acetamide
CAS 5474-23-7C20H24N4O5S