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Murcko scaffold

N-(Benzo[d]thiazol-2-yl)-4-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)benzamide scaffold

70 chemicals on CompoundList share this ring system.

Rings
5
Scaffold atoms
31
Chemicals
70
With full pages
7
Scaffold SMILES

O=C(Nc1nc2ccccc2s1)c1ccc(S(=O)(=O)N2CCc3ccccc3C2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the N-(Benzo[d]thiazol-2-yl)-4-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)benzamide page
Murcko scaffold O=C(Nc1nc2ccccc2s1)c1ccc(S(=O)(=O)N2CCc3ccccc3C2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 70 chemicals

N-(6-Fluoro-1,3-benzothiazol-2-yl)-4-(1,2,3,4-tetrahydroisoquinoline-2-sulfonyl)benzamide chemical structure, C23H18FN3O3S2, CAS 361480-56-0
N-(6-Fluoro-1,3-benzothiazol-2-yl)-4-(1,2,3,4-tetrahydroisoquinoline-2-sulfonyl)benzamide
CAS 361480-56-0C23H18FN3O3S2
4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(4-ethoxybenzo[d]thiazol-2-yl)benzamide chemical structure, C25H23N3O4S2, CAS 501351-60-6
4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(4-ethoxybenzo[d]thiazol-2-yl)benzamide
CAS 501351-60-6C25H23N3O4S2
(E)-Methyl 2-((4-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)benzoyl)imino)-3-methyl-2,3-dihydrobenzo[d]thiazole-6-carboxylate chemical structure, C26H23N3O5S2, CAS 850909-20-5
(E)-Methyl 2-((4-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)benzoyl)imino)-3-methyl-2,3-dihydrobenzo[d]thiazole-6-carboxylate
CAS 850909-20-5C26H23N3O5S2
(E)-4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(6-fluoro-3-methylbenzo[d]thiazol-2(3H)-ylidene)benzamide chemical structure, C24H20FN3O3S2, CAS 850910-10-0
(E)-4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(6-fluoro-3-methylbenzo[d]thiazol-2(3H)-ylidene)benzamide
CAS 850910-10-0C24H20FN3O3S2
(E)-4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(3-ethyl-6-fluorobenzo[d]thiazol-2(3H)-ylidene)benzamide chemical structure, C25H22FN3O3S2, CAS 850910-30-4
(E)-4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(3-ethyl-6-fluorobenzo[d]thiazol-2(3H)-ylidene)benzamide
CAS 850910-30-4C25H22FN3O3S2
(E)-4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(3-ethylbenzo[d]thiazol-2(3H)-ylidene)benzamide chemical structure, C25H23N3O3S2, CAS 850910-78-0
(E)-4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(3-ethylbenzo[d]thiazol-2(3H)-ylidene)benzamide
CAS 850910-78-0C25H23N3O3S2
(E)-4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(3,4-dimethylbenzo[d]thiazol-2(3H)-ylidene)benzamide chemical structure, C25H23N3O3S2, CAS 850910-98-4
(E)-4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(3,4-dimethylbenzo[d]thiazol-2(3H)-ylidene)benzamide
CAS 850910-98-4C25H23N3O3S2
(Z)-4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(3-ethyl-4-methoxybenzo[d]thiazol-2(3H)-ylidene)benzamide chemical structure, C26H25N3O4S2, CAS 533868-59-6
(Z)-4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(3-ethyl-4-methoxybenzo[d]thiazol-2(3H)-ylidene)benzamide
CAS 533868-59-6C26H25N3O4S2
(Z)-4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(4-ethoxy-3-methylbenzo[d]thiazol-2(3H)-ylidene)benzamide chemical structure, C26H25N3O4S2, CAS 533869-08-8
(Z)-4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(4-ethoxy-3-methylbenzo[d]thiazol-2(3H)-ylidene)benzamide
CAS 533869-08-8C26H25N3O4S2
(Z)-4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(4-ethoxy-3-ethylbenzo[d]thiazol-2(3H)-ylidene)benzamide chemical structure, C27H27N3O4S2, CAS 533869-09-9
(Z)-4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(4-ethoxy-3-ethylbenzo[d]thiazol-2(3H)-ylidene)benzamide
CAS 533869-09-9C27H27N3O4S2
(E)-N-(4,6-Difluoro-3-methylbenzo[d]thiazol-2(3H)-ylidene)-4-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)benzamide chemical structure, C24H19F2N3O3S2, CAS 851079-86-2
(E)-N-(4,6-Difluoro-3-methylbenzo[d]thiazol-2(3H)-ylidene)-4-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)benzamide
CAS 851079-86-2C24H19F2N3O3S2
4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(4-fluorobenzo[d]thiazol-2-yl)benzamide chemical structure, C23H18FN3O3S2, CAS 862807-25-8
4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(4-fluorobenzo[d]thiazol-2-yl)benzamide
CAS 862807-25-8C23H18FN3O3S2
(E)-N-(6-Acetamido-3-methylbenzo[d]thiazol-2(3H)-ylidene)-4-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)benzamide chemical structure, C26H24N4O4S2, CAS 851080-24-5
(E)-N-(6-Acetamido-3-methylbenzo[d]thiazol-2(3H)-ylidene)-4-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)benzamide
CAS 851080-24-5C26H24N4O4S2
4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(4,7-dimethylbenzo[d]thiazol-2-yl)benzamide chemical structure, C25H23N3O3S2, CAS 896676-15-6
4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(4,7-dimethylbenzo[d]thiazol-2-yl)benzamide
CAS 896676-15-6C25H23N3O3S2
4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)benzamide chemical structure, C25H23N3O4S2, CAS 896676-17-8
4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)benzamide
CAS 896676-17-8C25H23N3O4S2
(Z)-Methyl 2-(2-((4-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)benzoyl)imino)-6-sulfamoylbenzo[d]thiazol-3(2H)-yl)acetate chemical structure, C26H24N4O7S3, CAS 865199-00-4
(Z)-Methyl 2-(2-((4-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)benzoyl)imino)-6-sulfamoylbenzo[d]thiazol-3(2H)-yl)acetate
CAS 865199-00-4C26H24N4O7S3
N-(6-Chlorobenzo[d]thiazol-2-yl)-4-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)benzamide chemical structure, C23H18ClN3O3S2, CAS 361480-52-6
N-(6-Chlorobenzo[d]thiazol-2-yl)-4-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)benzamide
CAS 361480-52-6C23H18ClN3O3S2
(Z)-4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(3-(2-ethoxyethyl)-6-fluorobenzo[d]thiazol-2(3H)-ylidene)benzamide chemical structure, C27H26FN3O4S2, CAS 865163-06-0
(Z)-4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(3-(2-ethoxyethyl)-6-fluorobenzo[d]thiazol-2(3H)-ylidene)benzamide
CAS 865163-06-0C27H26FN3O4S2
(Z)-Ethyl 2-(2-((4-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)benzoyl)imino)-6-methoxybenzo[d]thiazol-3(2H)-yl)acetate chemical structure, C28H27N3O6S2, CAS 1025620-00-1
(Z)-Ethyl 2-(2-((4-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)benzoyl)imino)-6-methoxybenzo[d]thiazol-3(2H)-yl)acetate
CAS 1025620-00-1C28H27N3O6S2
4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(6-ethoxybenzo[d]thiazol-2-yl)benzamide chemical structure, C25H23N3O4S2, CAS 361480-50-4
4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(6-ethoxybenzo[d]thiazol-2-yl)benzamide
CAS 361480-50-4C25H23N3O4S2
(Z)-4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(3-(2-ethoxyethyl)benzo[d]thiazol-2(3H)-ylidene)benzamide chemical structure, C27H27N3O4S2, CAS 865162-42-1
(Z)-4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(3-(2-ethoxyethyl)benzo[d]thiazol-2(3H)-ylidene)benzamide
CAS 865162-42-1C27H27N3O4S2
(E)-4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(3,6-dimethylbenzo[d]thiazol-2(3H)-ylidene)benzamide chemical structure, C25H23N3O3S2, CAS 391876-48-5
(E)-4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(3,6-dimethylbenzo[d]thiazol-2(3H)-ylidene)benzamide
CAS 391876-48-5C25H23N3O3S2
4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(6-sulfamoylbenzo[d]thiazol-2-yl)benzamide chemical structure, C23H20N4O5S3, CAS 361480-53-7
4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(6-sulfamoylbenzo[d]thiazol-2-yl)benzamide
CAS 361480-53-7C23H20N4O5S3
4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(4,7-dimethoxybenzo[d]thiazol-2-yl)benzamide chemical structure, C25H23N3O5S2, CAS 896676-36-1
4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-(4,7-dimethoxybenzo[d]thiazol-2-yl)benzamide
CAS 896676-36-1C25H23N3O5S2