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Murcko scaffold

Ring system with 4 rings and 26 atoms

25 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
26
Chemicals
25
With full pages
12
Scaffold SMILES

O=C(Nc1ccccc1)c1ccc2c(c1)C(=O)N(CC1CCCO1)C2=O

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1ccccc1)c1ccc2c(c1)C(=O)N(CC1CCCO1)C2=O

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 25 of 25 chemicals

5-({[1,3-Dioxo-2-(tetrahydrofuran-2-ylmethyl)-2,3-dihydro-1H-isoindol-5-yl]carbonyl}amino)benzene-1,3-dicarboxylic acid chemical structure, C22H18N2O8, CAS 5731-57-7
5-({[1,3-Dioxo-2-(tetrahydrofuran-2-ylmethyl)-2,3-dihydro-1H-isoindol-5-yl]carbonyl}amino)benzene-1,3-dicarboxylic acid
CAS 5731-57-7C22H18N2O8
N-(2,4-Dimethoxyphenyl)-1,3-dioxo-2-(oxolan-2-ylmethyl)isoindole-5-carboxamide chemical structure, C22H22N2O6, CAS 292074-95-4
N-(2,4-Dimethoxyphenyl)-1,3-dioxo-2-(oxolan-2-ylmethyl)isoindole-5-carboxamide
CAS 292074-95-4C22H22N2O6
N-(4-Methoxyphenyl)-1,3-dioxo-2-(oxolan-2-ylmethyl)isoindole-5-carboxamide chemical structure, C21H20N2O5, CAS 294892-20-9
N-(4-Methoxyphenyl)-1,3-dioxo-2-(oxolan-2-ylmethyl)isoindole-5-carboxamide
CAS 294892-20-9C21H20N2O5
3-[[[1,3-Dioxo-2-(2-oxolanylmethyl)-5-isoindolyl]-oxomethyl]amino]benzoic acid chemical structure, C21H18N2O6, CAS 371143-28-1
3-[[[1,3-Dioxo-2-(2-oxolanylmethyl)-5-isoindolyl]-oxomethyl]amino]benzoic acid
CAS 371143-28-1C21H18N2O6
2-[[1,3-Dioxo-2-(oxolan-2-ylmethyl)isoindole-5-carbonyl]amino]benzoic acid chemical structure, C21H18N2O6, CAS 378211-03-1
2-[[1,3-Dioxo-2-(oxolan-2-ylmethyl)isoindole-5-carbonyl]amino]benzoic acid
CAS 378211-03-1C21H18N2O6
N-(2-Methoxy-5-nitrophenyl)-1,3-dioxo-2-(oxolan-2-ylmethyl)isoindole-5-carboxamide chemical structure, C21H19N3O7, CAS 355403-13-3
N-(2-Methoxy-5-nitrophenyl)-1,3-dioxo-2-(oxolan-2-ylmethyl)isoindole-5-carboxamide
CAS 355403-13-3C21H19N3O7
5-Bromo-2-({[1,3-dioxo-2-(tetrahydrofuran-2-ylmethyl)-2,3-dihydro-1H-isoindol-5-yl]carbonyl}amino)benzoic acid chemical structure, C21H17BrN2O6, CAS 405904-65-6
5-Bromo-2-({[1,3-dioxo-2-(tetrahydrofuran-2-ylmethyl)-2,3-dihydro-1H-isoindol-5-yl]carbonyl}amino)benzoic acid
CAS 405904-65-6C21H17BrN2O6
2-({[1,3-Dioxo-2-(tetrahydrofuran-2-ylmethyl)-2,3-dihydro-1H-isoindol-5-yl]carbonyl}amino)-4,5-dimethoxybenzoic acid chemical structure, C23H22N2O8, CAS 405894-72-6
2-({[1,3-Dioxo-2-(tetrahydrofuran-2-ylmethyl)-2,3-dihydro-1H-isoindol-5-yl]carbonyl}amino)-4,5-dimethoxybenzoic acid
CAS 405894-72-6C23H22N2O8
[4-({[1,3-Dioxo-2-(tetrahydrofuran-2-ylmethyl)-2,3-dihydro-1H-isoindol-5-yl]carbonyl}amino)phenoxy]acetic acid chemical structure, C22H20N2O7, CAS 294892-65-2
[4-({[1,3-Dioxo-2-(tetrahydrofuran-2-ylmethyl)-2,3-dihydro-1H-isoindol-5-yl]carbonyl}amino)phenoxy]acetic acid
CAS 294892-65-2C22H20N2O7
N-(4-Bromo-2-methylphenyl)-1,3-dioxo-2-(oxolan-2-ylmethyl)isoindole-5-carboxamide chemical structure, C21H19BrN2O4, CAS 404585-13-3
N-(4-Bromo-2-methylphenyl)-1,3-dioxo-2-(oxolan-2-ylmethyl)isoindole-5-carboxamide
CAS 404585-13-3C21H19BrN2O4
N-(2-Hydroxy-5-methylphenyl)-1,3-dioxo-2-(oxolan-2-ylmethyl)isoindole-5-carboxamide chemical structure, C21H20N2O5, CAS 380571-81-3
N-(2-Hydroxy-5-methylphenyl)-1,3-dioxo-2-(oxolan-2-ylmethyl)isoindole-5-carboxamide
CAS 380571-81-3C21H20N2O5
N-(5-Chloro-2-hydroxyphenyl)-1,3-dioxo-2-(oxolan-2-ylmethyl)isoindole-5-carboxamide chemical structure, C20H17ClN2O5, CAS 381197-58-6
N-(5-Chloro-2-hydroxyphenyl)-1,3-dioxo-2-(oxolan-2-ylmethyl)isoindole-5-carboxamide
CAS 381197-58-6C20H17ClN2O5
N-(2-Methoxyphenyl)-1,3-dioxo-2-(oxolan-2-ylmethyl)isoindole-5-carboxamide chemical structure, C21H20N2O5, CAS 404366-05-8
N-(2-Methoxyphenyl)-1,3-dioxo-2-(oxolan-2-ylmethyl)isoindole-5-carboxamide
CAS 404366-05-8C21H20N2O5
N-(2-Hydroxyphenyl)-1,3-dioxo-2-(oxolan-2-ylmethyl)isoindole-5-carboxamide chemical structure, C20H18N2O5, CAS 439947-12-3
N-(2-Hydroxyphenyl)-1,3-dioxo-2-(oxolan-2-ylmethyl)isoindole-5-carboxamide
CAS 439947-12-3C20H18N2O5
1,3-Dioxo-2-(oxolan-2-ylmethyl)-N-(4-propan-2-ylphenyl)isoindole-5-carboxamide chemical structure, C23H24N2O4, CAS 434292-60-1
1,3-Dioxo-2-(oxolan-2-ylmethyl)-N-(4-propan-2-ylphenyl)isoindole-5-carboxamide
CAS 434292-60-1C23H24N2O4
Methyl 3-[[1,3-dioxo-2-(oxolan-2-ylmethyl)isoindole-5-carbonyl]amino]benzoate chemical structure, C22H20N2O6, CAS 434298-96-1
Methyl 3-[[1,3-dioxo-2-(oxolan-2-ylmethyl)isoindole-5-carbonyl]amino]benzoate
CAS 434298-96-1C22H20N2O6
N-(3-Hydroxy-4-methoxyphenyl)-1,3-dioxo-2-(oxolan-2-ylmethyl)isoindole-5-carboxamide chemical structure, C21H20N2O6, CAS 405901-67-9
N-(3-Hydroxy-4-methoxyphenyl)-1,3-dioxo-2-(oxolan-2-ylmethyl)isoindole-5-carboxamide
CAS 405901-67-9C21H20N2O6
N-(3-Chloro-2-methylphenyl)-1,3-dioxo-2-(oxolan-2-ylmethyl)isoindole-5-carboxamide chemical structure, C21H19ClN2O4, CAS 690681-51-7
N-(3-Chloro-2-methylphenyl)-1,3-dioxo-2-(oxolan-2-ylmethyl)isoindole-5-carboxamide
CAS 690681-51-7C21H19ClN2O4
N-(2-Chloro-4-nitrophenyl)-1,3-dioxo-2-(oxolan-2-ylmethyl)isoindole-5-carboxamide chemical structure, C20H16ClN3O6, CAS 692283-72-0
N-(2-Chloro-4-nitrophenyl)-1,3-dioxo-2-(oxolan-2-ylmethyl)isoindole-5-carboxamide
CAS 692283-72-0C20H16ClN3O6
Methyl 4-[[1,3-dioxo-2-(oxolan-2-ylmethyl)isoindole-5-carbonyl]amino]benzoate chemical structure, C22H20N2O6, CAS 666710-75-4
Methyl 4-[[1,3-dioxo-2-(oxolan-2-ylmethyl)isoindole-5-carbonyl]amino]benzoate
CAS 666710-75-4C22H20N2O6
Methyl [4-({[1,3-dioxo-2-(tetrahydrofuran-2-ylmethyl)-2,3-dihydro-1H-isoindol-5-yl]carbonyl}amino)phenyl]acetate chemical structure, C23H22N2O6, CAS 518008-48-5
Methyl [4-({[1,3-dioxo-2-(tetrahydrofuran-2-ylmethyl)-2,3-dihydro-1H-isoindol-5-yl]carbonyl}amino)phenyl]acetate
CAS 518008-48-5C23H22N2O6
[4-({[1,3-Dioxo-2-(tetrahydrofuran-2-ylmethyl)-2,3-dihydro-1H-isoindol-5-yl]carbonyl}amino)phenyl]acetic acid chemical structure, C22H20N2O6, CAS 666710-73-2
[4-({[1,3-Dioxo-2-(tetrahydrofuran-2-ylmethyl)-2,3-dihydro-1H-isoindol-5-yl]carbonyl}amino)phenyl]acetic acid
CAS 666710-73-2C22H20N2O6
N-(3,4-Dimethylphenyl)-1,3-dioxo-2-(oxolan-2-ylmethyl)isoindole-5-carboxamide chemical structure, C22H22N2O4, CAS 6035-87-6
N-(3,4-Dimethylphenyl)-1,3-dioxo-2-(oxolan-2-ylmethyl)isoindole-5-carboxamide
CAS 6035-87-6C22H22N2O4
1,3-Dioxo-2-(oxolan-2-ylmethyl)-N-[4-(trifluoromethyl)phenyl]isoindole-5-carboxamide chemical structure, C21H17F3N2O4, CAS 6043-12-5
1,3-Dioxo-2-(oxolan-2-ylmethyl)-N-[4-(trifluoromethyl)phenyl]isoindole-5-carboxamide
CAS 6043-12-5C21H17F3N2O4