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Murcko scaffold

Ring system with 5 rings and 28 atoms

4 chemicals on CompoundList share this ring system.

Rings
5
Scaffold atoms
28
Chemicals
4
With full pages
1
Scaffold SMILES

O=C1c2nc(-c3cncnc3)[nH]c2C(c2ccccc2)N1c1ccc[nH]c1=O

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1c2nc(-c3cncnc3)[nH]c2C(c2ccccc2)N1c1ccc[nH]c1=O

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 4 of 4 chemicals

Siremadlin chemical structure, C26H24Cl2N6O4, CAS 1448867-41-1
Siremadlin
CAS 1448867-41-1C26H24Cl2N6O4
Siremadlin succinate chemical structure, C30H30Cl2N6O8, CAS 1638193-48-2
Siremadlin succinate
CAS 1638193-48-2C30H30Cl2N6O8
Siremadlin (R enantiomer) chemical structure, C26H24Cl2N6O4, CAS 1448867-42-2
Siremadlin (R enantiomer)
CAS 1448867-42-2C26H24Cl2N6O4
5-(5-Chloro-1-methyl-2-oxopyridin-3-yl)-4-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-3-propan-2-yl-4H-pyrrolo[3,4-d]imidazol-6-one chemical structure, C26H24Cl2N6O4, CAS 1448867-40-0
5-(5-Chloro-1-methyl-2-oxopyridin-3-yl)-4-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-3-propan-2-yl-4H-pyrrolo[3,4-d]imidazol-6-one
CAS 1448867-40-0C26H24Cl2N6O4