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Murcko scaffold

Ring system with 5 rings and 23 atoms

14 chemicals on CompoundList share this ring system.

Rings
5
Scaffold atoms
23
Chemicals
14
With full pages
5
Scaffold SMILES

O=C(CSc1ccc2c(n1)C1CCN2CC1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSc1ccc2c(n1)C1CCN2CC1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 14 of 14 chemicals

N-(4-Chlorophenyl)-2-[(7-cyano-3,4-dihydro-2H-1,4-ethano-1,5-naphthyridin-6-yl)sulfanyl]acetamide chemical structure, C19H17ClN4OS, CAS 723748-43-4
N-(4-Chlorophenyl)-2-[(7-cyano-3,4-dihydro-2H-1,4-ethano-1,5-naphthyridin-6-yl)sulfanyl]acetamide
CAS 723748-43-4C19H17ClN4OS
2-({4-Cyano-1,6-diazatricyclo[6.2.2.0^{2,7}]dodeca-2(7),3,5-trien-5-yl}sulfanyl)-N-(3,5-dichlorophenyl)acetamide chemical structure, C19H16Cl2N4OS, CAS 723748-45-6
2-({4-Cyano-1,6-diazatricyclo[6.2.2.0^{2,7}]dodeca-2(7),3,5-trien-5-yl}sulfanyl)-N-(3,5-dichlorophenyl)acetamide
CAS 723748-45-6C19H16Cl2N4OS
2-[(7-Cyano-3,4-dihydro-2H-1,4-ethano-1,5-naphthyridin-6-yl)sulfanyl]-N-(2,5-dichlorophenyl)acetamide chemical structure, C19H16Cl2N4OS, CAS 723748-47-8
2-[(7-Cyano-3,4-dihydro-2H-1,4-ethano-1,5-naphthyridin-6-yl)sulfanyl]-N-(2,5-dichlorophenyl)acetamide
CAS 723748-47-8C19H16Cl2N4OS
2-[(7-Cyano-3,4-dihydro-2H-1,4-ethano-1,5-naphthyridin-6-yl)sulfanyl]-N-(4-fluorophenyl)acetamide chemical structure, C19H17FN4OS, CAS 727679-31-4
2-[(7-Cyano-3,4-dihydro-2H-1,4-ethano-1,5-naphthyridin-6-yl)sulfanyl]-N-(4-fluorophenyl)acetamide
CAS 727679-31-4C19H17FN4OS
2-[(7-Cyano-3,4-dihydro-2H-1,4-ethano-1,5-naphthyridin-6-yl)sulfanyl]-N-(2-methoxyphenyl)acetamide chemical structure, C20H20N4O2S, CAS 728001-53-4
2-[(7-Cyano-3,4-dihydro-2H-1,4-ethano-1,5-naphthyridin-6-yl)sulfanyl]-N-(2-methoxyphenyl)acetamide
CAS 728001-53-4C20H20N4O2S
2-((7-Cyano-3,4-dihydro-2H-1,4-ethano-1,5-naphthyridin-6-yl)thio)-N-(4-(trifluoromethyl)phenyl)acetamide chemical structure, C20H17F3N4OS, CAS 728003-20-1
2-((7-Cyano-3,4-dihydro-2H-1,4-ethano-1,5-naphthyridin-6-yl)thio)-N-(4-(trifluoromethyl)phenyl)acetamide
CAS 728003-20-1C20H17F3N4OS
2-[(7-Cyano-3,4-dihydro-2H-1,4-ethano-1,5-naphthyridin-6-yl)sulfanyl]-N-(3-cyanophenyl)acetamide chemical structure, C20H17N5OS, CAS 728038-07-1
2-[(7-Cyano-3,4-dihydro-2H-1,4-ethano-1,5-naphthyridin-6-yl)sulfanyl]-N-(3-cyanophenyl)acetamide
CAS 728038-07-1C20H17N5OS
2-[(7-Cyano-3,4-dihydro-2H-1,4-ethano-1,5-naphthyridin-6-yl)sulfanyl]-N-(3-fluorophenyl)acetamide chemical structure, C19H17FN4OS, CAS 728885-86-7
2-[(7-Cyano-3,4-dihydro-2H-1,4-ethano-1,5-naphthyridin-6-yl)sulfanyl]-N-(3-fluorophenyl)acetamide
CAS 728885-86-7C19H17FN4OS
2-[(7-Cyano-3,4-dihydro-2H-1,4-ethano-1,5-naphthyridin-6-yl)sulfanyl]-N-[4-(trifluoromethoxy)phenyl]acetamide chemical structure, C20H17F3N4O2S, CAS 728885-88-9
2-[(7-Cyano-3,4-dihydro-2H-1,4-ethano-1,5-naphthyridin-6-yl)sulfanyl]-N-[4-(trifluoromethoxy)phenyl]acetamide
CAS 728885-88-9C20H17F3N4O2S
N-(3-Chloro-4-fluorophenyl)-2-[(7-cyano-3,4-dihydro-2H-1,4-ethano-1,5-naphthyridin-6-yl)sulfanyl]acetamide chemical structure, C19H16ClFN4OS, CAS 728885-96-9
N-(3-Chloro-4-fluorophenyl)-2-[(7-cyano-3,4-dihydro-2H-1,4-ethano-1,5-naphthyridin-6-yl)sulfanyl]acetamide
CAS 728885-96-9C19H16ClFN4OS
N-(5-Chloro-2-methoxyphenyl)-2-[(7-cyano-3,4-dihydro-2H-1,4-ethano-1,5-naphthyridin-6-yl)sulfanyl]acetamide chemical structure, C20H19ClN4O2S, CAS 728886-14-4
N-(5-Chloro-2-methoxyphenyl)-2-[(7-cyano-3,4-dihydro-2H-1,4-ethano-1,5-naphthyridin-6-yl)sulfanyl]acetamide
CAS 728886-14-4C20H19ClN4O2S
N-[4-Chloro-3-(trifluoromethyl)phenyl]-2-[(7-cyano-3,4-dihydro-2H-1,4-ethano-1,5-naphthyridin-6-yl)sulfanyl]acetamide chemical structure, C20H16ClF3N4OS, CAS 728888-23-1
N-[4-Chloro-3-(trifluoromethyl)phenyl]-2-[(7-cyano-3,4-dihydro-2H-1,4-ethano-1,5-naphthyridin-6-yl)sulfanyl]acetamide
CAS 728888-23-1C20H16ClF3N4OS
2-[(7-Cyano-3,4-dihydro-2H-1,4-ethano-1,5-naphthyridin-6-yl)sulfanyl]-N-(2,6-dichlorophenyl)acetamide chemical structure, C19H16Cl2N4OS, CAS 728888-41-3
2-[(7-Cyano-3,4-dihydro-2H-1,4-ethano-1,5-naphthyridin-6-yl)sulfanyl]-N-(2,6-dichlorophenyl)acetamide
CAS 728888-41-3C19H16Cl2N4OS
2-[(7-Cyano-3,4-dihydro-2H-1,4-ethano-1,5-naphthyridin-6-yl)sulfanyl]-N-(3-ethoxyphenyl)acetamide chemical structure, C21H22N4O2S, CAS 899368-66-2
2-[(7-Cyano-3,4-dihydro-2H-1,4-ethano-1,5-naphthyridin-6-yl)sulfanyl]-N-(3-ethoxyphenyl)acetamide
CAS 899368-66-2C21H22N4O2S