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Murcko scaffold

Ring system with 4 rings and 23 atoms

137 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
23
Chemicals
137
With full pages
7
Scaffold SMILES

O=C1C=C(C(=O)c2cc3ccccc3o2)C(c2ccccc2)N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1C=C(C(=O)c2cc3ccccc3o2)C(c2ccccc2)N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 137 chemicals

Methyl 4-{3-(1-benzofuran-2-ylcarbonyl)-1-[3-(dimethylamino)propyl]-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-2-yl}benzoate chemical structure, C26H26N2O6, CAS 618364-03-7
Methyl 4-{3-(1-benzofuran-2-ylcarbonyl)-1-[3-(dimethylamino)propyl]-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-2-yl}benzoate
CAS 618364-03-7C26H26N2O6
4-(Benzofuran-2-carbonyl)-1-(3-(dimethylamino)propyl)-3-hydroxy-5-(p-tolyl)-1H-pyrrol-2(5H)-one chemical structure, C25H26N2O4, CAS 618363-67-0
4-(Benzofuran-2-carbonyl)-1-(3-(dimethylamino)propyl)-3-hydroxy-5-(p-tolyl)-1H-pyrrol-2(5H)-one
CAS 618363-67-0C25H26N2O4
4-(1-Benzofuran-2-ylcarbonyl)-1-[3-(dimethylamino)propyl]-3-hydroxy-5-phenyl-1,5-dihydro-2H-pyrrol-2-one chemical structure, C24H24N2O4, CAS 618363-65-8
4-(1-Benzofuran-2-ylcarbonyl)-1-[3-(dimethylamino)propyl]-3-hydroxy-5-phenyl-1,5-dihydro-2H-pyrrol-2-one
CAS 618363-65-8C24H24N2O4
4-(1-Benzofuran-2-ylcarbonyl)-1-[2-(dimethylamino)ethyl]-3-hydroxy-5-(2-methoxyphenyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C24H24N2O5, CAS 797765-45-8
4-(1-Benzofuran-2-ylcarbonyl)-1-[2-(dimethylamino)ethyl]-3-hydroxy-5-(2-methoxyphenyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 797765-45-8C24H24N2O5
4-(Benzo[d]furan-2-ylcarbonyl)-5-(2,3-dimethoxyphenyl)-1-[2-(dimethylamino)eth yl]-3-hydroxy-3-pyrrolin-2-one chemical structure, C25H26N2O6, CAS 638134-41-5
4-(Benzo[d]furan-2-ylcarbonyl)-5-(2,3-dimethoxyphenyl)-1-[2-(dimethylamino)eth yl]-3-hydroxy-3-pyrrolin-2-one
CAS 638134-41-5C25H26N2O6
1-(2-(Dimethylamino)ethyl)-5-(4-fluorophenyl)-3-hydroxy-4-(7-methoxybenzofuran-2-carbonyl)-1H-pyrrol-2(5H)-one chemical structure, C24H23FN2O5, CAS 623539-57-1
1-(2-(Dimethylamino)ethyl)-5-(4-fluorophenyl)-3-hydroxy-4-(7-methoxybenzofuran-2-carbonyl)-1H-pyrrol-2(5H)-one
CAS 623539-57-1C24H23FN2O5
5-(3,4-Dimethoxyphenyl)-1-[3-(dimethylamino)propyl]-3-hydroxy-4-[(7-methoxyben zo[d]furan-2-yl)carbonyl]-3-pyrrolin-2-one chemical structure, C27H30N2O7, CAS 623536-52-7
5-(3,4-Dimethoxyphenyl)-1-[3-(dimethylamino)propyl]-3-hydroxy-4-[(7-methoxyben zo[d]furan-2-yl)carbonyl]-3-pyrrolin-2-one
CAS 623536-52-7C27H30N2O7
4-(Benzofuran-2-carbonyl)-1-(2-(diethylamino)ethyl)-3-hydroxy-5-(p-tolyl)-1H-pyrrol-2(5H)-one chemical structure, C26H28N2O4, CAS 618366-26-0
4-(Benzofuran-2-carbonyl)-1-(2-(diethylamino)ethyl)-3-hydroxy-5-(p-tolyl)-1H-pyrrol-2(5H)-one
CAS 618366-26-0C26H28N2O4
5-(3-Bromophenyl)-3-hydroxy-4-(7-methoxy-1-benzofuran-2-carbonyl)-1-(2-methoxyethyl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C23H20BrNO6, CAS 623537-24-6
5-(3-Bromophenyl)-3-hydroxy-4-(7-methoxy-1-benzofuran-2-carbonyl)-1-(2-methoxyethyl)-2,5-dihydro-1H-pyrrol-2-one
CAS 623537-24-6C23H20BrNO6
4-(1-Benzofuran-2-carbonyl)-1-[2-(dimethylamino)ethyl]-3-hydroxy-5-[3-(prop-2-en-1-yloxy)phenyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C26H26N2O5, CAS 623126-68-1
4-(1-Benzofuran-2-carbonyl)-1-[2-(dimethylamino)ethyl]-3-hydroxy-5-[3-(prop-2-en-1-yloxy)phenyl]-2,5-dihydro-1H-pyrrol-2-one
CAS 623126-68-1C26H26N2O5
4-(Benzo[d]furan-2-ylcarbonyl)-5-(2,3-dimethoxyphenyl)-1-[3-(dimethylamino)pro pyl]-3-hydroxy-3-pyrrolin-2-one chemical structure, C26H28N2O6, CAS 636991-87-2
4-(Benzo[d]furan-2-ylcarbonyl)-5-(2,3-dimethoxyphenyl)-1-[3-(dimethylamino)pro pyl]-3-hydroxy-3-pyrrolin-2-one
CAS 636991-87-2C26H28N2O6
5-(4-Chlorophenyl)-3-hydroxy-4-(7-methoxy-1-benzofuran-2-carbonyl)-1-(2-methoxyethyl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C23H20ClNO6, CAS 623537-18-8
5-(4-Chlorophenyl)-3-hydroxy-4-(7-methoxy-1-benzofuran-2-carbonyl)-1-(2-methoxyethyl)-2,5-dihydro-1H-pyrrol-2-one
CAS 623537-18-8C23H20ClNO6
5-(3,4-Dichlorophenyl)-3-hydroxy-4-(7-methoxy-1-benzofuran-2-carbonyl)-1-(3-methoxypropyl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C24H21Cl2NO6, CAS 623538-32-9
5-(3,4-Dichlorophenyl)-3-hydroxy-4-(7-methoxy-1-benzofuran-2-carbonyl)-1-(3-methoxypropyl)-2,5-dihydro-1H-pyrrol-2-one
CAS 623538-32-9C24H21Cl2NO6
1-[3-(Diethylamino)propyl]-5-(2-fluorophenyl)-3-hydroxy-4-[(7-methoxy-1-benzofuran-2-yl)carbonyl]-1,5-dihydro-2H-pyrrol-2-one chemical structure, C27H29FN2O5, CAS 620930-29-2
1-[3-(Diethylamino)propyl]-5-(2-fluorophenyl)-3-hydroxy-4-[(7-methoxy-1-benzofuran-2-yl)carbonyl]-1,5-dihydro-2H-pyrrol-2-one
CAS 620930-29-2C27H29FN2O5
4-(1-Benzofuran-2-carbonyl)-1-[3-(dimethylamino)propyl]-3-hydroxy-5-[3-(prop-2-en-1-yloxy)phenyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C27H28N2O5, CAS 623126-99-8
4-(1-Benzofuran-2-carbonyl)-1-[3-(dimethylamino)propyl]-3-hydroxy-5-[3-(prop-2-en-1-yloxy)phenyl]-2,5-dihydro-1H-pyrrol-2-one
CAS 623126-99-8C27H28N2O5
1-[3-(Dimethylamino)propyl]-5-(2-fluorophenyl)-3-hydroxy-4-(7-methoxy-1-benzofuran-2-carbonyl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C25H25FN2O5, CAS 623536-84-5
1-[3-(Dimethylamino)propyl]-5-(2-fluorophenyl)-3-hydroxy-4-(7-methoxy-1-benzofuran-2-carbonyl)-2,5-dihydro-1H-pyrrol-2-one
CAS 623536-84-5C25H25FN2O5
4-(Benzofuran-2-carbonyl)-5-(4-chlorophenyl)-1-(3-(dimethylamino)propyl)-3-hydroxy-1H-pyrrol-2(5H)-one chemical structure, C24H23ClN2O4, CAS 618363-66-9
4-(Benzofuran-2-carbonyl)-5-(4-chlorophenyl)-1-(3-(dimethylamino)propyl)-3-hydroxy-1H-pyrrol-2(5H)-one
CAS 618363-66-9C24H23ClN2O4
Methyl 4-{1-[2-(diethylamino)ethyl]-4-hydroxy-3-[(7-methoxybenzo[d]furan-2-yl) carbonyl]-5-oxo-3-pyrrolin-2-yl}benzoate chemical structure, C28H30N2O7, CAS 623543-05-5
Methyl 4-{1-[2-(diethylamino)ethyl]-4-hydroxy-3-[(7-methoxybenzo[d]furan-2-yl) carbonyl]-5-oxo-3-pyrrolin-2-yl}benzoate
CAS 623543-05-5C28H30N2O7
1-[3-(Diethylamino)propyl]-3-hydroxy-4-[(7-methoxybenzo[d]furan-2-yl)carbonyl]-5-[4-(methylethyl)phenyl]-3-pyrrolin-2-one chemical structure, C30H36N2O5, CAS 848213-82-1
1-[3-(Diethylamino)propyl]-3-hydroxy-4-[(7-methoxybenzo[d]furan-2-yl)carbonyl]-5-[4-(methylethyl)phenyl]-3-pyrrolin-2-one
CAS 848213-82-1C30H36N2O5
1-[2-(Diethylamino)ethyl]-3-hydroxy-4-[(7-methoxy-1-benzofuran-2-yl)carbonyl]-5-(2-methoxyphenyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C27H30N2O6, CAS 848213-62-7
1-[2-(Diethylamino)ethyl]-3-hydroxy-4-[(7-methoxy-1-benzofuran-2-yl)carbonyl]-5-(2-methoxyphenyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 848213-62-7C27H30N2O6
4-(1-Benzofuran-2-ylcarbonyl)-1-[2-(diethylamino)ethyl]-5-(3-fluorophenyl)-3-hydroxy-1,5-dihydro-2H-pyrrol-2-one chemical structure, C25H25FN2O4, CAS 797017-07-3
4-(1-Benzofuran-2-ylcarbonyl)-1-[2-(diethylamino)ethyl]-5-(3-fluorophenyl)-3-hydroxy-1,5-dihydro-2H-pyrrol-2-one
CAS 797017-07-3C25H25FN2O4
1-[2-(Diethylamino)ethyl]-3-hydroxy-4-[(7-methoxybenzo[d]furan-2-yl)carbonyl]-5-(3,4,5-trimethoxyphenyl)-3-pyrrolin-2-one chemical structure, C29H34N2O8, CAS 623542-81-4
1-[2-(Diethylamino)ethyl]-3-hydroxy-4-[(7-methoxybenzo[d]furan-2-yl)carbonyl]-5-(3,4,5-trimethoxyphenyl)-3-pyrrolin-2-one
CAS 623542-81-4C29H34N2O8
4-(Benzo[d]furan-2-ylcarbonyl)-5-(2,5-dimethoxyphenyl)-1-[2-(dimethylamino)eth yl]-3-hydroxy-3-pyrrolin-2-one chemical structure, C25H26N2O6, CAS 797796-26-0
4-(Benzo[d]furan-2-ylcarbonyl)-5-(2,5-dimethoxyphenyl)-1-[2-(dimethylamino)eth yl]-3-hydroxy-3-pyrrolin-2-one
CAS 797796-26-0C25H26N2O6
1-[3-(Diethylamino)propyl]-3-hydroxy-4-[(7-methoxybenzo[d]furan-2-yl)carbonyl]-5-(4-methylphenyl)-3-pyrrolin-2-one chemical structure, C28H32N2O5, CAS 620930-03-2
1-[3-(Diethylamino)propyl]-3-hydroxy-4-[(7-methoxybenzo[d]furan-2-yl)carbonyl]-5-(4-methylphenyl)-3-pyrrolin-2-one
CAS 620930-03-2C28H32N2O5