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Murcko scaffold

Ring system with 3 rings and 19 atoms

20 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
20
With full pages
1
Scaffold SMILES

O=C(COc1ccccc1)Nc1[nH]nc2c1CSC2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(COc1ccccc1)Nc1[nH]nc2c1CSC2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 20 of 20 chemicals

N-(2-tert-Butyl-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-2-phenoxypropanamide chemical structure, C18H23N3O2S, CAS 450340-14-4
N-(2-tert-Butyl-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-2-phenoxypropanamide
CAS 450340-14-4C18H23N3O2S
N-(2-tert-Butyl-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-2-(2,4-dichlorophenoxy)acetamide chemical structure, C17H19Cl2N3O2S, CAS 392256-23-4
N-(2-tert-Butyl-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-2-(2,4-dichlorophenoxy)acetamide
CAS 392256-23-4C17H19Cl2N3O2S
N-(2-(tert-Butyl)-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)-2-phenoxyacetamide chemical structure, C17H21N3O2S, CAS 361477-33-0
N-(2-(tert-Butyl)-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)-2-phenoxyacetamide
CAS 361477-33-0C17H21N3O2S
N-(2-tert-Butyl-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-2-(2-methoxyphenoxy)acetamide chemical structure, C18H23N3O3S, CAS 893927-88-3
N-(2-tert-Butyl-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-2-(2-methoxyphenoxy)acetamide
CAS 893927-88-3C18H23N3O3S
N-(2-tert-Butyl-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-2-(3-methoxyphenoxy)acetamide chemical structure, C18H23N3O3S, CAS 893927-96-3
N-(2-tert-Butyl-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-2-(3-methoxyphenoxy)acetamide
CAS 893927-96-3C18H23N3O3S
N-(2-tert-Butyl-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-2-(4-methoxyphenoxy)acetamide chemical structure, C18H23N3O3S, CAS 893928-04-6
N-(2-tert-Butyl-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-2-(4-methoxyphenoxy)acetamide
CAS 893928-04-6C18H23N3O3S
N-(2-tert-Butyl-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-2-(2-methylphenoxy)acetamide chemical structure, C18H23N3O2S, CAS 893928-11-5
N-(2-tert-Butyl-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-2-(2-methylphenoxy)acetamide
CAS 893928-11-5C18H23N3O2S
N-(2-tert-Butyl-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-2-(3-methylphenoxy)acetamide chemical structure, C18H23N3O2S, CAS 893928-18-2
N-(2-tert-Butyl-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-2-(3-methylphenoxy)acetamide
CAS 893928-18-2C18H23N3O2S
N-(2-tert-Butyl-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-2-(4-methylphenoxy)acetamide chemical structure, C18H23N3O2S, CAS 893928-25-1
N-(2-tert-Butyl-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-2-(4-methylphenoxy)acetamide
CAS 893928-25-1C18H23N3O2S
N-(2-(tert-Butyl)-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)-2-(4-isopropylphenoxy)acetamide chemical structure, C20H27N3O2S, CAS 893928-33-1
N-(2-(tert-Butyl)-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)-2-(4-isopropylphenoxy)acetamide
CAS 893928-33-1C20H27N3O2S
N-(2-tert-Butyl-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-2-(4-ethoxyphenoxy)acetamide chemical structure, C19H25N3O3S, CAS 893929-77-6
N-(2-tert-Butyl-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-2-(4-ethoxyphenoxy)acetamide
CAS 893929-77-6C19H25N3O3S
N-(2-(tert-Butyl)-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)-2-(4-chlorophenoxy)-2-methylpropanamide chemical structure, C19H24ClN3O2S, CAS 893927-74-7
N-(2-(tert-Butyl)-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)-2-(4-chlorophenoxy)-2-methylpropanamide
CAS 893927-74-7C19H24ClN3O2S
2-(2,4-Dichlorophenoxy)-N-{2-[(propylcarbamoyl)methyl]-2H,4H,6H-thieno[3,4-c]pyrazol-3-yl}acetamide chemical structure, C18H20Cl2N4O3S, CAS 1105202-24-1
2-(2,4-Dichlorophenoxy)-N-{2-[(propylcarbamoyl)methyl]-2H,4H,6H-thieno[3,4-c]pyrazol-3-yl}acetamide
CAS 1105202-24-1C18H20Cl2N4O3S
2-(4-Chlorophenoxy)-2-methyl-N-(2-(2-oxo-2-(propylamino)ethyl)-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)propanamide chemical structure, C20H25ClN4O3S, CAS 1105246-35-2
2-(4-Chlorophenoxy)-2-methyl-N-(2-(2-oxo-2-(propylamino)ethyl)-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)propanamide
CAS 1105246-35-2C20H25ClN4O3S
2-(2-Methoxyphenoxy)-N-(2-(2-oxo-2-(propylamino)ethyl)-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)acetamide chemical structure, C19H24N4O4S, CAS 1105202-31-0
2-(2-Methoxyphenoxy)-N-(2-(2-oxo-2-(propylamino)ethyl)-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)acetamide
CAS 1105202-31-0C19H24N4O4S
2-(4-Isopropylphenoxy)-N-(2-(2-oxo-2-(propylamino)ethyl)-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)acetamide chemical structure, C21H28N4O3S, CAS 1105246-41-0
2-(4-Isopropylphenoxy)-N-(2-(2-oxo-2-(propylamino)ethyl)-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)acetamide
CAS 1105246-41-0C21H28N4O3S
2-(2-Fluorophenoxy)-N-(2-(2-oxo-2-(propylamino)ethyl)-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)acetamide chemical structure, C18H21FN4O3S, CAS 1105202-38-7
2-(2-Fluorophenoxy)-N-(2-(2-oxo-2-(propylamino)ethyl)-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)acetamide
CAS 1105202-38-7C18H21FN4O3S
2-(4-Chlorophenoxy)-N-(2-(2-((2-methoxyethyl)amino)-2-oxoethyl)-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)acetamide chemical structure, C18H21ClN4O4S, CAS 1105204-00-9
2-(4-Chlorophenoxy)-N-(2-(2-((2-methoxyethyl)amino)-2-oxoethyl)-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)acetamide
CAS 1105204-00-9C18H21ClN4O4S
2-(4-Fluorophenoxy)-N-(2-{[(2-methoxyethyl)carbamoyl]methyl}-2H,4H,6H-thieno[3,4-c]pyrazol-3-yl)acetamide chemical structure, C18H21FN4O4S, CAS 1105248-17-6
2-(4-Fluorophenoxy)-N-(2-{[(2-methoxyethyl)carbamoyl]methyl}-2H,4H,6H-thieno[3,4-c]pyrazol-3-yl)acetamide
CAS 1105248-17-6C18H21FN4O4S
N-(2-(2-((2-Methoxyethyl)amino)-2-oxoethyl)-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)-2-phenoxypropanamide chemical structure, C19H24N4O4S, CAS 1105205-03-5
N-(2-(2-((2-Methoxyethyl)amino)-2-oxoethyl)-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)-2-phenoxypropanamide
CAS 1105205-03-5C19H24N4O4S