CompoundList
Sign in
Murcko scaffold

1,3-Dihydro-2H-imidazo[4,5-b]pyrazin-2-one scaffold

25 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
10
Chemicals
25
With full pages
3
Scaffold SMILES

O=c1[nH]c2nccnc2[nH]1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1,3-Dihydro-2H-imidazo[4,5-b]pyrazin-2-one page
Murcko scaffold O=c1[nH]c2nccnc2[nH]1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 25 of 25 chemicals

1,3-Dihydro-2H-imidazo[4,5-b]pyrazin-2-one chemical structure, C5H4N4O, CAS 16328-63-5
1,3-Dihydro-2H-imidazo[4,5-b]pyrazin-2-one
CAS 16328-63-5C5H4N4O
1,3-Dimethyl-1,3-dihydro-2H-imidazo[4,5-b]pyrazin-2-one chemical structure, C7H8N4O, CAS 84996-53-2
1,3-Dimethyl-1,3-dihydro-2H-imidazo[4,5-b]pyrazin-2-one
CAS 84996-53-2C7H8N4O
N,1,3-trimethyl-5-(methylamino)-2-oxoimidazo[4,5-b]pyrazine-6-carboxamide chemical structure, C10H14N6O2, CAS 33070-51-8
N,1,3-trimethyl-5-(methylamino)-2-oxoimidazo[4,5-b]pyrazine-6-carboxamide
CAS 33070-51-8C10H14N6O2
5,6-Dichloro-1,3-dihydro-2H-imidazo[4,5-b]pyrazin-2-one chemical structure, C5H2Cl2N4O, CAS 79100-20-2
5,6-Dichloro-1,3-dihydro-2H-imidazo[4,5-b]pyrazin-2-one
CAS 79100-20-2C5H2Cl2N4O
1,5,6-Trimethyl-1,4-dihydro-2H-imidazo[4,5-B]pyrazin-2-one chemical structure, C8H10N4O, CAS 53114-85-5
1,5,6-Trimethyl-1,4-dihydro-2H-imidazo[4,5-B]pyrazin-2-one
CAS 53114-85-5C8H10N4O
Tirasemtiv chemical structure, C12H14N4O, CAS 1005491-05-3
Tirasemtiv
CAS 1005491-05-3C12H14N4O
5-Chloro-1,3-dihydro-2H-imidazo(4,5-b)pyrazin-2-one chemical structure, C5H3ClN4O, CAS 33386-23-1
5-Chloro-1,3-dihydro-2H-imidazo(4,5-b)pyrazin-2-one
CAS 33386-23-1C5H3ClN4O
5-(Ethylamino)-1H-imidazo[4,5-b]pyrazin-2(3H)-one chemical structure, C7H9N5O, CAS 27523-76-8
5-(Ethylamino)-1H-imidazo[4,5-b]pyrazin-2(3H)-one
CAS 27523-76-8C7H9N5O
6-Bromo-1-(pentan-3-yl)-1H-imidazo[4,5-b]pyrazin-2-ol chemical structure, C10H13BrN4O, CAS 1005490-98-1
6-Bromo-1-(pentan-3-yl)-1H-imidazo[4,5-b]pyrazin-2-ol
CAS 1005490-98-1C10H13BrN4O
tert-Butyl 5-bromo-2-oxo-3-(pentan-3-yl)-2,3-dihydroimidazo[4,5-b]pyrazine-1-carboxylate chemical structure, C15H21BrN4O3, CAS 1005491-08-6
tert-Butyl 5-bromo-2-oxo-3-(pentan-3-yl)-2,3-dihydroimidazo[4,5-b]pyrazine-1-carboxylate
CAS 1005491-08-6C15H21BrN4O3
1-(Pentan-3-yl)-6-((trimethylsilyl)ethynyl)-1H-imidazo[4,5-b]pyrazin-2-ol chemical structure, C15H22N4OSi, CAS 1005491-06-4
1-(Pentan-3-yl)-6-((trimethylsilyl)ethynyl)-1H-imidazo[4,5-b]pyrazin-2-ol
CAS 1005491-06-4C15H22N4OSi
1-(Pentan-3-yl)-6-(prop-1-yn-1-yl)-1,3-dihydro-2H-imidazo[4,5-b]pyrazin-2-one chemical structure, C13H16N4O, CAS 1005491-53-1
1-(Pentan-3-yl)-6-(prop-1-yn-1-yl)-1,3-dihydro-2H-imidazo[4,5-b]pyrazin-2-one
CAS 1005491-53-1C13H16N4O
1-Methyl-1H,2H,3H-imidazo(4,5-b)pyrazin-2-one chemical structure, C6H6N4O, CAS 84996-45-2
1-Methyl-1H,2H,3H-imidazo(4,5-b)pyrazin-2-one
CAS 84996-45-2C6H6N4O
5-Bromo-1H,2H,3H-imidazo[4,5-b]pyrazin-2-one chemical structure, C5H3BrN4O, CAS 1260763-85-6
5-Bromo-1H,2H,3H-imidazo[4,5-b]pyrazin-2-one
CAS 1260763-85-6C5H3BrN4O
5,6-Dimethyl-1H-imidazo[4,5-b]pyrazin-2(3H)-one chemical structure, C7H8N4O, CAS 53114-75-3
5,6-Dimethyl-1H-imidazo[4,5-b]pyrazin-2(3H)-one
CAS 53114-75-3C7H8N4O
5-Iodo-1H-imidazo[4,5-b]pyrazin-2(3H)-one chemical structure, C5H3IN4O, CAS 2092796-24-0
5-Iodo-1H-imidazo[4,5-b]pyrazin-2(3H)-one
CAS 2092796-24-0C5H3IN4O
5-Chloro-6-(ethylamino)-1,3-dihydro-2H-imidazo[4,5-b]pyrazin-2-one chemical structure, C7H8ClN5O, CAS 27604-23-5
5-Chloro-6-(ethylamino)-1,3-dihydro-2H-imidazo[4,5-b]pyrazin-2-one
CAS 27604-23-5C7H8ClN5O
5-Chloro-6-(dimethylamino)-1,3-dihydroimidazo[4,5-b]pyrazin-2-one chemical structure, C7H8ClN5O, CAS 27604-20-2
5-Chloro-6-(dimethylamino)-1,3-dihydroimidazo[4,5-b]pyrazin-2-one
CAS 27604-20-2C7H8ClN5O
5-Chloro-6-(methylamino)-1,3-dihydroimidazo[4,5-b]pyrazin-2-one chemical structure, C6H6ClN5O, CAS 27604-22-4
5-Chloro-6-(methylamino)-1,3-dihydroimidazo[4,5-b]pyrazin-2-one
CAS 27604-22-4C6H6ClN5O
5-Amino-6-chloro-4,7-dihydro-2H-imidazo[4,5-b]pyrazin-2-one chemical structure, C5H4ClN5O, CAS 27604-21-3
5-Amino-6-chloro-4,7-dihydro-2H-imidazo[4,5-b]pyrazin-2-one
CAS 27604-21-3C5H4ClN5O
6-Bromo-1-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyrazin-2-one chemical structure, C6H5BrN4O, CAS 1822854-85-2
6-Bromo-1-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyrazin-2-one
CAS 1822854-85-2C6H5BrN4O
5-Bromo-6-chloro-1,3-dihydro-2H-imidazo[4,5-b]pyrazin-2-one chemical structure, C5H2BrClN4O, CAS 2607086-87-1
5-Bromo-6-chloro-1,3-dihydro-2H-imidazo[4,5-b]pyrazin-2-one
CAS 2607086-87-1C5H2BrClN4O
2-Oxo-1H,2H,3H-imidazo[4,5-b]pyrazine-5-carboxylic acid chemical structure, C6H4N4O3, CAS 2995278-03-8
2-Oxo-1H,2H,3H-imidazo[4,5-b]pyrazine-5-carboxylic acid
CAS 2995278-03-8C6H4N4O3
Methyl 2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyrazine-5-carboxylate chemical structure, C7H6N4O3, CAS 2995275-19-7
Methyl 2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyrazine-5-carboxylate
CAS 2995275-19-7C7H6N4O3