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Murcko scaffold

Ring system with 4 rings and 25 atoms

23 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 25
Chemicals: 23
With full pages: 3

Scaffold SMILES

O=c1cc(-c2ccccc2)oc2cc(OCc3ccccc3)ccc12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=c1cc(-c2ccccc2)oc2cc(OCc3ccccc3)ccc12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 23 of 23 chemicals

7-(Benzyloxy)-5-hydroxy-2-phenyl-4H-chromen-4-one chemical structure, C22H16O4, CAS 110506-85-9

7-(Benzyloxy)-5-hydroxy-2-phenyl-4H-chromen-4-one

CAS 110506-85-9C₂₂H₁₆O₄

Methyl 4-{[(5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy]methyl}benzoate chemical structure, C24H18O6, CAS 313471-03-3

Methyl 4-{[(5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy]methyl}benzoate

CAS 313471-03-3C₂₄H₁₈O₆

7-[(4-Fluorophenyl)methoxy]-5-hydroxy-2-phenylchromen-4-one chemical structure, C22H15FO4, CAS 306321-93-7

7-[(4-Fluorophenyl)methoxy]-5-hydroxy-2-phenylchromen-4-one

CAS 306321-93-7C₂₂H₁₅FO₄

7-[(4-Chlorophenyl)methoxy]-5-hydroxy-2-phenylchromen-4-one chemical structure, C22H15ClO4, CAS 306321-96-0

7-[(4-Chlorophenyl)methoxy]-5-hydroxy-2-phenylchromen-4-one

CAS 306321-96-0C₂₂H₁₅ClO₄

5-Hydroxy-7-[(pentafluorobenzyl)oxy]-2-phenyl-4H-chromen-4-one chemical structure, C22H11F5O4, CAS 306321-75-5

5-Hydroxy-7-[(pentafluorobenzyl)oxy]-2-phenyl-4H-chromen-4-one

CAS 306321-75-5C₂₂H₁₁F₅O₄

5-Hydroxy-2-phenyl-7-[(4-vinylbenzyl)oxy]-4H-chromen-4-one chemical structure, C24H18O4, CAS 314745-41-0

5-Hydroxy-2-phenyl-7-[(4-vinylbenzyl)oxy]-4H-chromen-4-one

CAS 314745-41-0C₂₄H₁₈O₄

7-[(2,5-Dimethylbenzyl)oxy]-5-hydroxy-2-phenyl-4H-chromen-4-one chemical structure, C24H20O4, CAS 314745-36-3

7-[(2,5-Dimethylbenzyl)oxy]-5-hydroxy-2-phenyl-4H-chromen-4-one

CAS 314745-36-3C₂₄H₂₀O₄

7-[(2-Chloro-6-fluorobenzyl)oxy]-5-hydroxy-2-phenyl-4H-chromen-4-one chemical structure, C22H14ClFO4, CAS 314745-40-9

7-[(2-Chloro-6-fluorobenzyl)oxy]-5-hydroxy-2-phenyl-4H-chromen-4-one

CAS 314745-40-9C₂₂H₁₄ClFO₄

7-[(2,4-Difluorobenzyl)oxy]-5-hydroxy-2-phenyl-4H-chromen-4-one chemical structure, C22H14F2O4, CAS 849006-01-5

7-[(2,4-Difluorobenzyl)oxy]-5-hydroxy-2-phenyl-4H-chromen-4-one

CAS 849006-01-5C₂₂H₁₄F₂O₄

7-[(4-tert-Butylphenyl)methoxy]-5-hydroxy-2-phenyl-4H-chromen-4-one chemical structure, C26H24O4, CAS 314745-42-1

7-[(4-tert-Butylphenyl)methoxy]-5-hydroxy-2-phenyl-4H-chromen-4-one

CAS 314745-42-1C₂₆H₂₄O₄

7-[(2-Fluorobenzyl)oxy]-5-hydroxy-2-phenyl-4H-chromen-4-one chemical structure, C22H15FO4, CAS 326090-00-0

7-[(2-Fluorobenzyl)oxy]-5-hydroxy-2-phenyl-4H-chromen-4-one

CAS 326090-00-0C₂₂H₁₅FO₄

7-(Benzyloxy)-5-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one chemical structure, C24H20O5, CAS 111922-60-2

7-(Benzyloxy)-5-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one

CAS 111922-60-2C₂₄H₂₀O₅

2-(3,4-Dimethoxyphenyl)-5,6-dimethoxy-7-(phenylmethoxy)-4H-1-benzopyran-4-one chemical structure, C26H24O7, CAS 52378-71-9

2-(3,4-Dimethoxyphenyl)-5,6-dimethoxy-7-(phenylmethoxy)-4H-1-benzopyran-4-one

CAS 52378-71-9C₂₆H₂₄O₇

Cdk9-IN-10 chemical structure, C22H16O5, CAS 3542-63-0

CAS 3542-63-0C₂₂H₁₆O₅

5,6,8-Trimethoxy-2-(4-methoxyphenyl)-7-(phenylmethoxy)-4H-1-benzopyran-4-one chemical structure, C26H24O7, CAS 10176-76-8

5,6,8-Trimethoxy-2-(4-methoxyphenyl)-7-(phenylmethoxy)-4H-1-benzopyran-4-one

CAS 10176-76-8C₂₆H₂₄O₇

7-Benzyloxy-2-(3,4-dimethoxy-phenyl)-5-methoxy-chromen-4-one chemical structure, C25H22O6, CAS 203191-62-2

7-Benzyloxy-2-(3,4-dimethoxy-phenyl)-5-methoxy-chromen-4-one

CAS 203191-62-2C₂₅H₂₂O₆

7-(Benzyloxy)-3-hydroxy-5-m ethoxy-2-(4-m ethoxyphenyl)-4H-chromen-4-one chemical structure, C24H20O6, CAS 874202-33-2

7-(Benzyloxy)-3-hydroxy-5-m ethoxy-2-(4-m ethoxyphenyl)-4H-chromen-4-one

CAS 874202-33-2C₂₄H₂₀O₆

5,4'-Dihydroxy-7-(benzyloxy)flavone chemical structure, C22H16O5, CAS 20450-81-1

5,4'-Dihydroxy-7-(benzyloxy)flavone

CAS 20450-81-1C₂₂H₁₆O₅

7-O-Benzyl luteolin chemical structure, C22H16O6, CAS 1201808-24-3

7-O-Benzyl luteolin

CAS 1201808-24-3C₂₂H₁₆O₆

4H-1-Benzopyran-5-carbaldehyde,6-hydroxy-2-(4-methoxyphenyl)-4-oxo-7-(phenylmethoxy)- chemical structure, C24H18O6, CAS 6075-77-0

4H-1-Benzopyran-5-carbaldehyde,6-hydroxy-2-(4-methoxyphenyl)-4-oxo-7-(phenylmethoxy)-

CAS 6075-77-0C₂₄H₁₈O₆

7-(Benzyloxy)-5-methoxy-2-phenyl-4H-chromen-4-one chemical structure, C23H18O4, CAS 681294-57-5

7-(Benzyloxy)-5-methoxy-2-phenyl-4H-chromen-4-one

CAS 681294-57-5C₂₃H₁₈O₄

7-(Benzyloxy)-3-hydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one chemical structure, C23H18O5, CAS 35784-26-0

7-(Benzyloxy)-3-hydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one

CAS 35784-26-0C₂₃H₁₈O₅

7-(Benzyloxy)-2-(4-bromophenyl)-3-hydroxy-5-methoxy-4H-chromen-4-one chemical structure, C23H17BrO5, CAS 1402931-94-5

7-(Benzyloxy)-2-(4-bromophenyl)-3-hydroxy-5-methoxy-4H-chromen-4-one

CAS 1402931-94-5C₂₃H₁₇BrO₅