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Murcko scaffold

Ring system with 4 rings and 26 atoms

87 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
26
Chemicals
87
With full pages
6
Scaffold SMILES

O=C(Nc1ncc2c(n1)CC(c1ccccc1)CC2=O)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1ncc2c(n1)CC(c1ccccc1)CC2=O)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 87 chemicals

3,5-Dimethoxy-N-[7-(4-methoxyphenyl)-5-oxo-5,6,7,8-tetrahydroquinazolin-2-yl]benzamide chemical structure, C24H23N3O5, CAS 846584-09-6
3,5-Dimethoxy-N-[7-(4-methoxyphenyl)-5-oxo-5,6,7,8-tetrahydroquinazolin-2-yl]benzamide
CAS 846584-09-6C24H23N3O5
N-[7-(2,4-Dimethoxyphenyl)-5-oxo-5,6,7,8-tetrahydroquinazolin-2-yl]benzamide chemical structure, C23H21N3O4, CAS 847039-85-4
N-[7-(2,4-Dimethoxyphenyl)-5-oxo-5,6,7,8-tetrahydroquinazolin-2-yl]benzamide
CAS 847039-85-4C23H21N3O4
N-[7-(2,4-Dimethoxyphenyl)-5-oxo-5,6,7,8-tetrahydroquinazolin-2-yl]-2-methoxybenzamide chemical structure, C24H23N3O5, CAS 847365-03-1
N-[7-(2,4-Dimethoxyphenyl)-5-oxo-5,6,7,8-tetrahydroquinazolin-2-yl]-2-methoxybenzamide
CAS 847365-03-1C24H23N3O5
3-Methoxy-N-[7-(4-methoxyphenyl)-5-oxo-5,6,7,8-tetrahydroquinazolin-2-yl]benzamide chemical structure, C23H21N3O4, CAS 777872-34-1
3-Methoxy-N-[7-(4-methoxyphenyl)-5-oxo-5,6,7,8-tetrahydroquinazolin-2-yl]benzamide
CAS 777872-34-1C23H21N3O4
N-[7-(4-Methylphenyl)-5-oxo-7,8-dihydro-6H-quinazolin-2-yl]benzamide chemical structure, C22H19N3O2, CAS 354539-81-4
N-[7-(4-Methylphenyl)-5-oxo-7,8-dihydro-6H-quinazolin-2-yl]benzamide
CAS 354539-81-4C22H19N3O2
N-[7-(2-Chlorophenyl)-5-oxo-7,8-dihydro-6H-quinazolin-2-yl]benzamide chemical structure, C21H16ClN3O2, CAS 351164-04-0
N-[7-(2-Chlorophenyl)-5-oxo-7,8-dihydro-6H-quinazolin-2-yl]benzamide
CAS 351164-04-0C21H16ClN3O2
N-[7-(3,4-Dimethoxyphenyl)-5-oxo-7,8-dihydro-6H-quinazolin-2-yl]benzamide chemical structure, C23H21N3O4, CAS 374764-18-8
N-[7-(3,4-Dimethoxyphenyl)-5-oxo-7,8-dihydro-6H-quinazolin-2-yl]benzamide
CAS 374764-18-8C23H21N3O4
N-[7-(3-Chlorophenyl)-5-oxo-7,8-dihydro-6H-quinazolin-2-yl]benzamide chemical structure, C21H16ClN3O2, CAS 374769-63-8
N-[7-(3-Chlorophenyl)-5-oxo-7,8-dihydro-6H-quinazolin-2-yl]benzamide
CAS 374769-63-8C21H16ClN3O2
N-[5-Oxo-7-(3,4,5-trimethoxyphenyl)-5,6,7,8-tetrahydroquinazolin-2-yl]benzamide chemical structure, C24H23N3O5, CAS 525581-32-2
N-[5-Oxo-7-(3,4,5-trimethoxyphenyl)-5,6,7,8-tetrahydroquinazolin-2-yl]benzamide
CAS 525581-32-2C24H23N3O5
4-Chloro-N-[7-(4-fluorophenyl)-5-oxo-5,6,7,8-tetrahydroquinazolin-2-yl]benzamide chemical structure, C21H15ClFN3O2, CAS 775293-24-8
4-Chloro-N-[7-(4-fluorophenyl)-5-oxo-5,6,7,8-tetrahydroquinazolin-2-yl]benzamide
CAS 775293-24-8C21H15ClFN3O2
N-[7-(4-Chlorophenyl)-5-oxo-5,6,7,8-tetrahydroquinazolin-2-yl]-4-fluorobenzamide chemical structure, C21H15ClFN3O2, CAS 775293-34-0
N-[7-(4-Chlorophenyl)-5-oxo-5,6,7,8-tetrahydroquinazolin-2-yl]-4-fluorobenzamide
CAS 775293-34-0C21H15ClFN3O2
4-Methoxy-N-[7-(4-methoxyphenyl)-5-oxo-5,6,7,8-tetrahydro-2-quinazolinyl]benzamide chemical structure, C23H21N3O4, CAS 775293-58-8
4-Methoxy-N-[7-(4-methoxyphenyl)-5-oxo-5,6,7,8-tetrahydro-2-quinazolinyl]benzamide
CAS 775293-58-8C23H21N3O4
4-Fluoro-N-(5-oxo-7-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)benzamide chemical structure, C21H16FN3O2, CAS 775293-32-8
4-Fluoro-N-(5-oxo-7-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)benzamide
CAS 775293-32-8C21H16FN3O2
N-(7-(3-Chlorophenyl)-5-oxo-5,6,7,8-tetrahydro-2-quinazolinyl)-4-fluorobenzamide chemical structure, C21H15ClFN3O2, CAS 775293-42-0
N-(7-(3-Chlorophenyl)-5-oxo-5,6,7,8-tetrahydro-2-quinazolinyl)-4-fluorobenzamide
CAS 775293-42-0C21H15ClFN3O2
N-[7-(4-Chlorophenyl)-5-oxo-5,6,7,8-tetrahydroquinazolin-2-yl]-4-methylbenzamide chemical structure, C22H18ClN3O2, CAS 775293-10-2
N-[7-(4-Chlorophenyl)-5-oxo-5,6,7,8-tetrahydroquinazolin-2-yl]-4-methylbenzamide
CAS 775293-10-2C22H18ClN3O2
N-[7-(4-Fluorophenyl)-5-oxo-5,6,7,8-tetrahydroquinazolin-2-yl]-4-methoxybenzamide chemical structure, C22H18FN3O3, CAS 775293-56-6
N-[7-(4-Fluorophenyl)-5-oxo-5,6,7,8-tetrahydroquinazolin-2-yl]-4-methoxybenzamide
CAS 775293-56-6C22H18FN3O3
4-Fluoro-N-[5-oxo-7-(3,4,5-trimethoxyphenyl)-5,6,7,8-tetrahydroquinazolin-2-yl]benzamide chemical structure, C24H22FN3O5, CAS 775293-46-4
4-Fluoro-N-[5-oxo-7-(3,4,5-trimethoxyphenyl)-5,6,7,8-tetrahydroquinazolin-2-yl]benzamide
CAS 775293-46-4C24H22FN3O5
N-(7-(4-Methoxyphenyl)-5-oxo-5,6,7,8-tetrahydroquinazolin-2-yl)-4-methylbenzamide chemical structure, C23H21N3O3, CAS 775293-14-6
N-(7-(4-Methoxyphenyl)-5-oxo-5,6,7,8-tetrahydroquinazolin-2-yl)-4-methylbenzamide
CAS 775293-14-6C23H21N3O3
4-Methyl-N-[7-(4-methylphenyl)-5-oxo-5,6,7,8-tetrahydroquinazolin-2-yl]benzamide chemical structure, C23H21N3O2, CAS 775293-08-8
4-Methyl-N-[7-(4-methylphenyl)-5-oxo-5,6,7,8-tetrahydroquinazolin-2-yl]benzamide
CAS 775293-08-8C23H21N3O2
4-Methyl-N-(5-oxo-7-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)benzamide chemical structure, C22H19N3O2, CAS 775293-06-6
4-Methyl-N-(5-oxo-7-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)benzamide
CAS 775293-06-6C22H19N3O2
(4-Chlorophenyl)-N-[7-(4-methylphenyl)-5-oxo(6,7,8-trihydroquinazolin-2-yl)]ca rboxamide chemical structure, C22H18ClN3O2, CAS 775293-22-6
(4-Chlorophenyl)-N-[7-(4-methylphenyl)-5-oxo(6,7,8-trihydroquinazolin-2-yl)]ca rboxamide
CAS 775293-22-6C22H18ClN3O2
4-Fluoro-N-[7-(4-methoxyphenyl)-5-oxo-5,6,7,8-tetrahydroquinazolin-2-yl]benzamide chemical structure, C22H18FN3O3, CAS 775293-38-4
4-Fluoro-N-[7-(4-methoxyphenyl)-5-oxo-5,6,7,8-tetrahydroquinazolin-2-yl]benzamide
CAS 775293-38-4C22H18FN3O3
N-[7-(4-Fluorophenyl)-5-oxo-5,6,7,8-tetrahydroquinazolin-2-yl]benzamide chemical structure, C21H16FN3O2, CAS 333758-36-4
N-[7-(4-Fluorophenyl)-5-oxo-5,6,7,8-tetrahydroquinazolin-2-yl]benzamide
CAS 333758-36-4C21H16FN3O2
N-[7-(3,4-Dimethoxyphenyl)-5-oxo-5,6,7,8-tetrahydroquinazolin-2-yl]-4-methylbenzamide chemical structure, C24H23N3O4, CAS 775293-18-0
N-[7-(3,4-Dimethoxyphenyl)-5-oxo-5,6,7,8-tetrahydroquinazolin-2-yl]-4-methylbenzamide
CAS 775293-18-0C24H23N3O4